项目来源

国家重点研发计划(NKRD)

项目主持人

方剑乔

项目受资助机构

浙江中医药大学

立项年度

2018

立项时间

未公开

项目编号

2018YFC1704600

项目级别

国家级

研究期限

未知 / 未知

受资助金额

750.00万元

学科

中医药现代化研究

学科代码

未公开

基金类别

“中医药现代化研究”重点专项

关键词

经络现象 ; 心肺经 ; 循经感传 ; 生物学特征 ; 特异性 ; 机制研究 ; Meridian phenomena ; Heart and Lung meridians ; Propagated sensation along the channels ; Biological characteristics ; Specificity ; Mechanism research

参与者

周美启；高昕妍；曾芳；乔海法；蒋永亮

参与机构

安徽中医药大学；中国中医科学院针灸研究所；成都中医药大学；陕西中医药大学

项目标书摘要：本项目围绕心、肺经研究经络学说的经脉现象、经脉循行中体表—内脏之间、体表—体表之间的联系特点、规律及其生物学基础等关键问题。在“心、肺二经循经经脉现象的生物学特征”方面，已初步揭示健康者、心肺疾病患者心肺二经的微循环特性、热传输特性、代谢特性及电学特性，呈现相对特异性；在“心、肺经经脉循经现象的生物学机制”方面，已建立微透析—高效液相色谱—电喷雾串联四级杆质谱检测方法，发现大鼠DMNV核团中的神经递质含量与肺功能相关；在“心、肺经对心、肺功能的影响”方面，发现肺经五输穴对肺部疾病有特异性的治疗作用，心经五输穴对心脏疾病有特异性的治疗作用，电针改善心肌缺血小鼠心脏功能与α、β-AR表达有关；在“心、肺疾病的体表反应与心、肺经循行的相关性及机制研究”方面，发现心肺疾病模型大鼠体表神经源性反应分布与心肺经循行或同节段有较高一致性，心肺疾病患者出现的压痛点和局部皮肤异常改变与心肺经的循行部位存在着高度重合性；在“基于经脉“体表—内脏”联系的循经针刺效应的临床评价”方面，已制定针刺干预慢性持续性哮喘和慢性稳定型心绞痛的临床研究方案，并开展临床研究；在“基于经脉“体表—体表”联系的循经针刺效应的临床评价及其机制”方面，已制定针刺干预肩前痛和颈型颈椎病的临床研究方案，并开展临床研究。

Application Abstract: This project focuses on key questions of the meridian theory,such as meridian phenomena,characteristics and rules underlying distributions and associations of meridians(meridian-viscera and site-to-site association),as well as the biological basis of meridians.Regarding biological characteristics of meridian phenomena for the heart and lung meridians,we have preliminary revealed the microcirculatory,thermal,metabolic and electrical characteristics of these two meridians in healthy adults and patients of cardiopulmonary diseases.Results indicate that meridian specificity exists.Regarding biological mechanism of meridian phenomena for these two meridians,detection methods of microdialysis sampling and high performance liquid chromatography-electrospray tandem mass spectrometry have been established.Results indicate that the content of neurotransmitter in the dorsal motor nucleus of the vagus has correlation with the lung function.Regarding effects of these two meridians on cardiopulmonary functions,results reveal five-shu acupoints of lung meridian have specific therapeutic effect on lung diseases.Five-shu acupoints of heart meridian have specific therapeutic effect on heart diseases and electroacupuncture can improve the heart function in myocardial ischemia mice by regulating expression of α and β-AR.Regarding correlations and mechanism investigations between peripheral responses of cardiopulmonary diseases and distributions of these two meridians,results indicate that distributions of neurogenic responses in rats of cardiopulmonary diseases is consistent with circulations of these two meridians or the the same segment.In patients of cardiopulmonary diseases,distributions of tender points and regional abnormal skin changes are also highly coincident with the circulation of these two meridians.Regarding clinical evaluations on the effect of acupuncture according to the meridian-viscera association theory,protocols of acupuncture on chronic persistent asthma and stable angina pectoris are built and trials are ongoing.Regarding the mechanism clinical evaluation on the effect of acupuncture based on the site-to-site association theory,protocols of acupuncture on anterior shoulder pain and cervical spondylosis are established and trials are ongoing.

项目受资助省

浙江省