项目来源
巴西圣保罗研究基金(FAPESP)
项目主持人
Maria Bernadete Sasso Stuani
项目受资助机构
Faculdade de Odontologia de Ribeirão Preto.Universidade de São Paulo.Ribeirão Preto,SP,Brazil
项目编号
20/10095-2
立项年度
2021
立项时间
未公开
研究期限
未知 / 未知
项目级别
国家级
受资助金额
未知
学科
Health Sciences
学科代码
未公开
基金类别
Scholarships in Brazil-Scientific Initiation
关键词
Imunoensaio ; Ortodontia ; Mini-implantes ; Materiais ortodônticos ; Microesferas ; Anti-inflamatórios ; Biomarcadores ;
参与者
Mariah Carboni Mendes
参与机构
未公开
项目标书摘要：Little is known about the inflammatory response to miniscrew loading.Better understanding of the biomarkers involved in this process may help to reduce the risk factors that can lead to the premature loss of the miniscrew.Objectives:The aim of this study will be to evaluate the levels of IL-1±,IL-1²,IL-1Ra,IL-10,IL-13 in the peri-miniscrew implant crevicular fluid(MICF).Methods:The study sample will be comprise 20 immediately loaded(Group I)and 20 unloaded miniscrews(Group II).A load in the range of 150 to 200gF will be immediately applied to the miniscrews in the loaded group after the placement surgery.MICF was collected at three different time points:at baseline(T0),at day 7(T2)and at day 14(T3).The levels of the biomarkers will be measured using a multiplexed bead immunoassay.Intergroup comparisons will be made using Mann-Whitney test.Friedman and Dunn's multiple comparison tests will be used to evaluate intragroup differences over time.
Application Abstract: Little is known about the inflammatory response to miniscrew loading.Better understanding of the biomarkers involved in this process may help to reduce the risk factors that can lead to the premature loss of the miniscrew.Objectives:The aim of this study will be to evaluate the levels of IL-1±,IL-1²,IL-1Ra,IL-10,IL-13 in the peri-miniscrew implant crevicular fluid(MICF).Methods:The study sample will be comprise 20 immediately loaded(Group I)and 20 unloaded miniscrews(Group II).A load in the range of 150 to 200gF will be immediately applied to the miniscrews in the loaded group after the placement surgery.MICF was collected at three different time points:at baseline(T0),at day 7(T2)and at day 14(T3).The levels of the biomarkers will be measured using a multiplexed bead immunoassay.Intergroup comparisons will be made using Mann-Whitney test.Friedman and Dunn's multiple comparison tests will be used to evaluate intragroup differences over time.
