＜正···来,···病率···率呈···增和···趋势···已成···范围···有致···恶性···一[···据统···01···世界···者高···0万···所有···13···年约···0万···肺癌···有肿···总数···%[···肺癌···学行···小细···（s···l ···l ···g ···ce···CL···非小···癌（···-s···l ···l ···g ···ce···SC···两种···NS···是肺··

Cu···at··· e···en···ha···nd···te···ha···el···ro···ay···pp···s ···ce···ro···; ···ev··· t···un···ly··· m···an··· r···ir···fu···er···ve···ga···n.··· t···pr···nt···ud···A5···ce··· w··· t···te···it···ar···s ···ce···at···s ···ce···tr··· L··· c···er···ll···ol···ra···n ··· e···ua··· u···g ···MT···ss···an···bs···ed···de··· m···os···e.···ll···op···is···s ···ec··· b···nn···n ···lu···sc··· i···hi···an···/p···id··· i···de···ub···la···ed···ow···to···ry···he···su··· d···ns···te···ha···el···ro···up···ss···pr···fe···io···nd···du··· a···to··· i··· d···-i···pe···nt···nn··· C···st··· m···al···de···as···he···os···ry···io···ev··· o···ig··· t···sd···r ··· a···va··· o···ra···ri···on···(S···3)···d ··· B···ll···mp···a-···Bc···)/···-2···so···te··· p···ei···Ba···ra···. ···mi···RN···mi···4 ··· m···18··· w··· p···ic···d ···ta···t ···T3···TA···ac···at··· w···in···it···in···R-···or···R-···b-···at···A5···ce··· c···ar···wi···th···on···l ···at···t.···e ···io··· B···2/··· w···fu···er···du··· i···iR··· o···iR···1b···ea··· A··· c···s.···e ···ul···we···fu···er···nf···ed··· d···ct··· i···no···r ···g ···no···ci···a ···l ···e,···EP···2.··· s···ar···th···es···s ···th···re···t ···dy···mo···ra··· t··· c···st··· t···tm··· s···re···d ··· p···if···ti···an···nd···d ···pt···s ···re···at··· t···ex···ss··· l···ls··· m···24···d ···-1···.

Se···al···ud··· h··· d···ns···te···ha···an··· r···os···it···ty··· a···ci···d ···h ··· d···gu···io···f ···yc···ut···e ···at···sh···be···en···My···nd···s ···ra···re···ta··· o···un···de···ar···om···em···s ···le··· I···hi···tu··· w···st···is··· r···at···-r···st··· A··· c··· m···l ···49···, ··· i···st···te···he···le···f ···yc···d ··· i···ad···io···nd···d ···ot···ci···of···49···ll···Ap···os···de···ti···sh···d ···t ···re···re···we···po···ti···el···in···49···ce··· t···te···it···ad···io···ha···n ···9 ···ls···es···n ···tt··· r···lt···em···tr···d ··· i···rs···xp···si···pa···rn··· c···c ··· F···in···49···d ···9/···el··· S···re···on··· c···c ···re···on··· s···l ···er···in···NA···iR··· d···la··· e···nc···nt··· F···me···te···po···si···n ···9/···el··· a···mp···in··· s···if···nt···cr···e ···Bi···Bc···, ···-c···as···, ···an···3 ··· i···ea···of···x.··· c···ra··· F···me···te···po···si···as···te···te···hi···Fa···xp···si···wa···up···ss···by···to··· e···es···n ···c-··· i···54···el··· M···ov··· d···ea··· c··· v···il··· a···in···as···in···ti···of···op···is···re···se···d ···A5···R ···ls···ll···d ···co···na···na···re···en···f ···yc···RN···nd···ra···ti··· w···ea···up···ul···on··· c···c ···uc···th···en···iv··· o···54···el···to···ra···ti··· T···e ···ul···in···at···th···c-··· a···Fa···eg···te···he···ns···vi···of···49···ll···o ···ad···io···y ···ul···ng···sp···-8···di···d ··· a···va···n ··· t···su···qu··· a···ci···on···th···e ···oc···dr··· p···wa···f ···pt···s.

Mi···RN···05···iR···5)···s ···ea··· a··· n···l ···gn···ic···d ···gn···ic···om···er···r ···g ···ce···bu···he···su··· i···he···bl···ed···pe···we···in···si···nt···hi···et···na···is···me···o ···es···at···he···ag···ti···nd···og···ti···ol···of···R-··· i···at···ts···th···ng···nc··· T···ll···16···ig···e ···ic··· w··· i···ud··· a···g ···ch··· a···cl···in···ti···ed···e ···gn···ic···lu···f ···-2··· 5···ti···s ···mi··· i···pr···os··· v···es···nd···ar···le···ud··· b··· d···no···c ··· p···no···c ···ue···Fo···he···ag···ti···et···na···is···he···ol···se···ti···y,···ec···ci··· p···ti···li···ih··· r···o,···ga···e ···el···od···ti···di···os··· o··· r···o,···d ··· o···al···re···nd···th···ur···of···R-··· f···pa···nt···it···un···an··· w··· 0··· (··· C··· 0··· -···94···0.···(9···CI···0.···- ···6)···.0···95···I ···.4··· 6···),···16···5%··· =···08···0.···, ···86···5%··· =···29···71···),···d ···0 ···% ···= ···7 ···.9··· r···ec···el···in···at··· t··· m···20···s ···se··· b···ar··· f···di···os··· o···un···an···. ··· s···ro···an···si···ur···r ···on···at···th···mi···05···d ···ex···le···ov···ll···cu···y ··· d···ct··· w··· t···ue···mp··· c···ar···it···lo···sa···es···or···e ···gn···ic···ta···al···s,···e ···le···ut···e ···th···is···e-···e ···vi··· a···re···re···-f··· s···iv···an···se···ev···ed···at···cr···ed···R-··· l···ls···d ···ro···ti···ro···in···e ···gn···s ···pa···nt···it···un···an··· (···le···R ···.8···95···I:···78···96··· =···83··· =···00··· I···on···si··· m···20···ay··· a···om···ng···om···er···r ···ec···n,···ed···in···he···cu···nc···f ···ie··· w··· l··· c···er·

Mi···RN···pl···im···ta···ro··· i···um···ge···is··· v···ou···yp···of···nc···. ···-3··· c···in···it···el···ro···er···on··· s··· c···er···bu···he···ol···c ···es··· m···32···in···ng···nc···ne···to··· f···he···tu···d.···re···e ···es···at···th···ol···of···R-···a ···su···es···g ··· p···if···ti···of···ng···en···rc···ma···ll···Mi···20···re···en···as···un···o ···ec···el···up···ss···EP···2 ··· A··· c··· p···if···ti··· a···in···e ···e ···pt···c ···ls···th···ra···ti···tr···me···co···re···it···on···l ···at···t.···r ···ul···al···sh···d ···t ···-3···, ···a ···el···RN···di···tl···eg···te···ig··· t···sd···r ··· a···va··· o···ra···ri···on···(S···3)···d ··· s···al···su···as···l(···, ···, ··· C···as···. ··· s···A-···ib···d ···T3···ve···fu···er···ov···it···ol···in···gu···in···TA···si···ls···or···er···iR···0a···ea···nt···fe···ve···su···es··· c···er···ll···ow···in···ce···no···ft···om···ed···th···nt···s,···d ···ni···an··· i···bi··· c··· m···at··· i···it···an···n ···o.···r ···di··· c···ec···el···em···tr···d ···t ···-3···, ···di···tl···eg···ti···ST··· s···al···no···nl···up···ss···ce···pr···fe···io···nd···ta···si···bu···ls···nh···ed···ra···ti···in···ed···op···is··· a···oc···in···a ···ls·

肺癌···率和···位居···性肿···,每···诊肺···中约···%为···胞肺···on···al···el···un···an···,N···C）···NS···发生···机制···有效···法尤···。M···oR···mi···）是···度约···~2···基、···非编···分子···,在···程中···可能···变或···靶基···序列···变异···现象···核苷···性（···gl···uc···ti···po···or···sm···P）···来研···,m···A及···P可···基因···基因···CL···生发···重要···在N···C患···、血···织、···尿液···和胸···中都···表达···RN···SN···成为···生物···。本···年来···iR···其相···P在···LC···和诊···作用···述。

目的···铂对···P-···细胞···R-···、B···2、···d3···影响···顺铂···机制···体外···TE···-2···实验···不同···铂,···照组···顺铂···;倒···镜观···细胞···台盼···法计···存活···TT···顺铂···EP···2细···制率···定量···检测···-3···we···rn···ot···析细···cl···Sm···蛋白···变化···随着···用剂···加,···P-···细胞···加,···-3···顺铂···的细···表达···趋势···l-···ma···表达···降。···铂可···上调···-3···表达···步抑···l-···ma···表达···LT···a-···的凋··

Cy···n ···is···vo···d ···th···at···og···f ···cu··· c···li···io···of···pe···di···te···el···us···2D··· T··· s···y ···es···at···th···ol···f ···li···2-···ul···d ···NA···n ···ot···ia···el···ro···er···on··· T···. ···ul···sh···d ···t ···he···lu···e ···ce···at··· (··· g··· s···if···nt···pr···te···he···ol···ra···n ···ra···or··· e···th···al···ll···RA···s)···nd···gn···ca···y ···re···d ··· e···es···n ···cy···n ···an···ho···or···ti···of···ti···la···ma···(p···1)··· R···Cs···mp···d ···h ···se···de···ow···uc··· c···en···ti··· T···cy···n ···3'···tr···la··· r···on··· t···et···by···R-··· a···em···tr···d ···mi··· a···ys···so···ar···We···rn···ot···so···nf···ed···at···cl···D2···d ···B1···pr···io···as···gu···ed··· m···98···he···su··· i···ca··· t··· m···98···ea···nt···n ···uc···AO···ap···os··· T···su···es···n ···RA··· g···th··· m···98···gh···e ···at···to···gu···io···f ···-2···ax···d ···pa···9 ···re···on···ur···rm···, ··· e···es···n ···el···f ···-9···ec···se···n ··· g···gl···se···ea··· c···s ···pa··· w··· t···e ···at···by···w ···co···co···nt···io···Si···ar··· t···ex···ss··· o···iR··· s···if···nt···de···as···in···rt···of···ta···sh···st···to···oc···(S···-i···ce···ia···ic···t ···el···mp···d ···h ···t ···co···ol···ts···ut···cl···D2···d ···B1···ve···re···ka··· i···ea··· i···or··· o···TZ···du··· d···et···ra···co···re···it···ho···in···al··· c···ro···at···In···nc···io···th···st··· d···ns···te···ha···ig···lu···e ···ce···at··· i···ce···yc··· D···p-···ul···on···d ···-9···ow···eg···ti···in···e ···EC···By···gu···in···yc··· D···mi···8 ··· i···bi···um···en···he···l ···l ···wt···th···by···ov···ng···ve···he···eu··· t···et···or···sc···r ···pl···ti···of···DM·

Si···e ···le···de···ly···ph···s ···Ps···n ···an···nc···bb···do···n ···ta···ng···an···en···RN··· (···D1···1)···ve···en···so···te···it···an··· d···lo···nt···n ···s ···a-···ly···, ···mo···pr···se···es···at···th···ss···at···s ···we···th··· e···es···n ···nt···ti···tr··· l··· S··· i···NR···AS···rs···73··· r···40···, ··· r···61···) ··· c···er···sc···ib···ty···he···ta···r ···ee···Ps···re···tr···ed···om···ig···e ···di··· w···h ···lu··· 5···3 ···ie··· a···5,··· c···ro··· O···al···no···gn···ca···as···ia···ns···tw··· S··· i···NR···AS···rs···73··· r···40···, ··· r···61···) ··· c···er···sk···re···se···d.···we···, ···fu···er···bg···p ···ly··· b···d ···ca···r ···e,··· f···d ···t ··· A···le···of···37···28···cr···ed···e ···k ···so···ca···r ···bo···al···e ···tr··· (···= ···5,···% ···= ···5 ···.2···an···ec···iv···od··· (···= ···9;···% ···= ···3 ···.4··· T···A ···el···f ···94···2 ··· t···G ···el···f ···26···4 ···o ···re···d ··· r··· o···om···an··· i···n ···an···pu···io···n ···el···on···st···R ···.1···95···I ···.0··· 1···, ··· O··· 1···, ··· C··· 1··· -···34···es···ti···y)···d ···es···e ···el···OR···1.··· 9···CI···1.···- ···7,···d ···= ···9;···% ···= ···3 ···.8···re···ct···ly···Th··· r···57···, ···94···2,···d ···26···4 ···ZN···-A···ar···ll···so···te···it···nc···se···om···an··· r··· i···n ···an···pu···io··

Ai···In···du···on···om···re···us···ud··· r···rt···no···gn···ca···as···ia···n ···co···mi···fr··· o···eg···bl··· o···ru···an···eg···bl···co···ne···wi···ty···2 ···be···. ···er···ep···ed···at···ly···gr···er···ta···of···ee···ea···ve···ab··· r···ce···he···sk··· t··· 2···ab···s.··· f···he···nv···ig··· t···re···io···ip···tw··· t···, ···ca···ed···t ···et···na···is··· e···ma···th···nd···nd··· e···ct···f ··· i···ke··· f···t,···ge···le···nd···be···n ··· r··· o···yp··· d···et···Ma···ia···an···et···s:···ar···s ···ME···NE···d ···AS···or···po··· o···ro···ct··· c···rt···ud··· p···is··· f··· 1···nu··· 1··· t···1 ···y ···4 ···e ···ri···ou···ch···in···ef···nc···is··· h···-s···ch··· j···na···an···on···ti···ex···ts···su···: ··· p···ar···na···is···cl···d ···ot···of··· (···+ ··· a···cl··· T···po···d ···im···ad···te···el···ve···sk··· t··· 2···ab···s ··· t···hi···st···ta···vs···e ···es···nt··· w··· 0··· (··· c···id···e ···er··· [··· 0···-0···) ··· t···l ···it···0.···(9···CI···66···84···or···ue···ri··· 0··· (··· C···.8···.9···fo···re···le··· v···ta···s,···72···5%··· 0···-0···) ··· y···ow···ge···le···0.···(9···CI···67···99···or···uc···ro···ve···ab··· a···0.···(9···CI···88···99···or···ui···ib···in···es···ig···ua···y ···di···in···ic···co··· w··· s···n ···gr···er···nd···87···5%··· 0···-0···) ··· v···ta··· f···r ···st···es···th···fo···w-···pe···d ···10···ar···r ···e.···cl···on···A ···he···nt··· o···ru··· e···ci···y ···ri··· a···gr··· l···y ···et···es···el··· v···ta···s,···uc···ro···ve···ab··· o···he···fi··· i···ss···at···wi···a ···er···sk··· t··· 2···ab···s.