Stress related · · · crescentus

项目来源

美国卫生和人类服务部基金(HHS)

项目主持人

REDDY, MICHAEL ·

项目受资助机构

UNIVERSITY OF · ·

项目编号

3R01GM111706-01S1

立项年度

2015

立项时间

未公开

项目级别

国家级

研究期限

未知 / 未知

受资助金额

35628.00美元

学科

GENETICS

学科代码

未公开

基金类别

Non-SBIR/STTR RPGs

关键词

未公开

参与者

CHIEN, PETER ·

参与机构

NATIONAL INSTITUTE · · · SCIENCES

项目标书摘要:DESCRIPTION (provided · · · use energy · · · respond to · · · proteases serve · · · destroying aberrant, · · · proteins and · · · signals through · · · factors. Cells · · · in response · · · how regulated · · · cell cycle · · · is currently · · · proposal addresses · · · proteases target · · · a combination · · · and proteomic · · · on proteases · · · from the · · · crescentus. Aims · · · determine how · · · during proteotoxic · · · the Lon · · · the replication · · · cause growth · · · Aims 3 · · · on how · · · the clamp · · · by the · · · critical for · · · during DNA · · · proteases and · · · highly conserved · · · these results · · · general understanding · · · and stress · · · role of · · · bacterial virulence · · · with the · · · these proteases · · · responses, suggests · · · excellent targets · · · new antibiotic · · · of immediate · · ·

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  • 1.An···se···al···gu···or··· B···er··· D···si···Li··· F··· t···el···al···yn···se···ti···io·

    • 关键词:
    • DIFFERENTIAL EXPRESSION ANALYSIS; PENICILLIN-BINDING PROTEINS;C-TERMINAL LINKER; CAULOBACTER-CRESCENTUS; CYTOKINETIC RING;CONSTRICTION RATE; SHAPE; PEPTIDOGLYCAN; ORGANIZATION; ZIPA
    • La···ie··· P···ic···.;···on···Ch···to···r ···Sa···ag···ol···o,···st···;H···ll···at···w;···tc···Al···on···;Z···er···Ri···;C···n,···te···ro··· P···la··· B···ol··· E··· D·
    • 《CU···NT···OL···》
    • 2019年
    • 29卷
    • 9期
    • 期刊

    Ba···ri···gr···h ··· d···si···re···re···se···on··· n···pe···do···ca···PG···nt···he···is···g ···l ···l ···PG···nt···e ···ym··· E···gi···ev···nc···ug···ts···at···ny··· s···ha··· r···ir···ct···ti···to···nc···n;···we···, ···is···cl··· h···ac···at··· o···iv···on···ec···c ···sy···as···oc···s.···e ···Z ···os···et···ha···ee···mp···at···as···re···at···of··· s···he··· d···ng···vi···n,···t ··· m···an···s ···ou···wh··· i···ct···re···kn···. ···e,··· s··· t··· F···, ···Ft···bi···ng···ot··· a···es···ti···re···at···of···ns···ct··· i···au···ac··· c···ce···s,···lp···in···ts···o ···sy···es···to···om··· d···si··· W···in···ha···yp···ct··· m···nt···f ··· P···yn···se···ts···nd···sl···ec···ca··· r···er···IA···ut···t ···er···vi···n ···es···on···se···al···ow···r,···IA··· s···l ···ui··· t···ai···in···op···co···ri···on···te···d ···ic···cy··· a···pe···ti···PG···nt···e ···kg···nd···nt···ui···y,···ss··· f··· i···he···es···e ···hy···ac···at···Ft··· c···es···ll···o ···at···bo···th···iv···on···an···ur··· c···tr···io···nd···ns···ze···el···to···ll···ll···ec···c ···ib···ic···We···mo···ra···th···Fz···de···de···si···li···to···vi···n-···ci··· P···yn···si···s ···se···d ···an···er···ph···ro···ba···ri··· A···ba···ri···tu···ac···s.···es···at···st···is···ha···zI···el···li···Ft···to···ll···ll···mo···in···nd··· r···ir···fo···ig···in···o ···h ···iv··· a···sp···al···or···t ···sy···es···du···g ···is···. ···ra··· o···fi···ng···up···t ··· p···di···th···ac···at··· o···ED···BP··· s···ha··· i··· b···dl···on···ve···eq···em··· f···ba···ri···mo···og···si··

    ...
  • 2.Re···at···Pr···ol···s ···Ba···ri·

    • 关键词:
    • ATP-DEPENDENT PROTEASES; SPECIFICITY-ENHANCING FACTOR; CELL-CYCLE PROGRESSION; AAA PLUS PROTEASE; ESCHERICHIA-COLI; LON PROTEASE; INORGANIC POLYPHOSPHATE; DNA-BINDING; RNA-POLYMERASE; DEGRADATION
    • Ma···ud···am···A.···ie···Pe···
    • 《AN···L ···IE···F ···CH···ST··· V···87》
    • 2018年
    • 会议

    Re···at···pr···ol···s ···a ···al···oc··· t··· a···ct···ll···vi···th···s.···ct···a ··· e···gy···pe···nt···A+···ot···es··· p···r ···ra···io···f ···fo···d ··· n···ve···gu···or···ro···ns···iv···th···pr···ol···s ···an···re···si··· e···t,···ec···ci···an···el···iv··· i···eg···in···ub···at···ar···ey···pe···ic··· i···ft···au···nt···th···gh···e ··· o···da···rs···at···di···th···nh···nt···ec···ci···of···e ···te···ti···ac···er···Re···at···pr···in···gr···ti···is···tr···te···li···d ···qu···ty···nt···, ···l-···le···og···si··· a···ph···ol···ca···ra···ti···. ···th···re···w,··· h···li··· r···nt···rk···at···s ···d ···ht··· o···un···st···in···f ···ul···d ···te···si···n ···te···. ···di···ss···e ···e ···+ ···te···s ···y ···in···al···ed···ow···as···ll··· h···th··· p···ea··· a···de···ye···ur··· c···ge···n ···wt···We···es··· e···pl···of···w ···te··· s···ct···ty···n ···co···ol··· i···nc···si···y ···pl···wa··· F···ll···we···sc···e ··· c···li···a ···e ···og···io···et···in··· t···ne··· m··· m···fy··· a···ts··· a···ne··· t···e ··· r···la··· p···ei···eg···at···.

    ...
  • 3.Pr···as···eg···ti···an···ap···ty···ri···Ca···ba···r ···wt·

    • 关键词:
    • POLYMERASE-III HOLOENZYME; BACTERIAL-CELL-CYCLE; AAA PLUS PROTEASE; ESCHERICHIA-COLI; GAMMA-SUBUNIT; CHROMOSOME-REPLICATION; TRANSCRIPTION FACTOR; MASTER REGULATOR; SLIDING CLAMP; PROTEOLYSIS
    • Va··· R···rt···;Z···er···Ri··· D···hi··· P···r
    • 《CU···NT···IN··· I···IC···IO···Y》
    • 2016年
    • 34卷
    • 期刊

    Ce···gr···h ···ui··· t···re···al··· p···ei···th···ar···nw···ed··· t···c.··· b···er··· A··· p···ea··· l··· t···Cl···am··· a···Lo···el···iv··· d···ro···ro···ns···fi··· b···nt···si···pe···ic··· o···da···rs···au···ac··· c···ce···s ···a ···m-···at··· b···er··· t··· u···rg··· a···bl···te···ve···me···l ···ns···on···er···el···iv···on···cl···He···we···gh···ht···ce···wo···th···re···ls···w ···ie···ch···f ···pt··· t···et···he···gr···ti···of···y ···te··· a···pe···ic···me···ur··· t··· c··· c···e,···te···ti···pr···in···st···ti···wi···ot··· c···. ···de···ib···ec··· i···gh···nt···ow···ul···ct···ma···es···A ···li···io···nd···pa···th···gh···n ··· C···pr···as··· B···us···ro···se···us···an··· a···oa···ub···at···ep···oi···th··· m··· b···et···s ···co···ns··· f···pr···as···at···ti···an···e ···cu···th··· s···ar···.

    ...
  • 5.Tw···ay···o ···n ···at···yl···si···ti··· a···bi···cs···n ···l ···te··· t···ug···ct···ti···or···hi···io···f ···P ···iv···

    • 关键词:
    • MYCOBACTERIUM-TUBERCULOSIS; PROTEASE; PEPTIDASE; COMPLEX; MODEL
    • Va··· R···rt···;C···n,···te·
    • 《MO···UL···MI···BI···GY》
    • 2016年
    • 101卷
    • 2期
    • 期刊

    In···ti···by···co···te···m ···er···os···(M··· h···ha··· d···st···ng···fe···on···e ···ld···pu···io···Ac···ep···ep···e ···ib···ic···AD···) ··· k···n ···ki···so···ba···ri···y ···r ···iv···ng···e ···te···l ···P ···ti···e.···EP···ti···ti···al···ta···t ···, ···h ··· a···mp···n ···t ···on···ll···AD···ac···at···pr···ol···s ···Cl···is···e ···mo···od···f ···li··· I···hi···ss···of···le···ar···cr···ol···, ···ul··· e···l.···w ···w ···t ···P'···ff···iv···ss··· m···ba···ri···s ···el···ue··· i···bi···n ···Cl···de···de···pr···as···ct···ty···th···th···ac···at···. ···s ···di···of···w ··· s··· a···bi···c ··· k··· b···er···by···th···in···it··· o···ct···ti···pr···as···il···tr···s ··· u···it···f ···ge···g ···se···zy··· f···so···y ···de···ew···ti···ti···

    ...
  • 6.An···ap··· H···ar··· R···la··· P···eo···is···ri···a ···te···l ···l ···le

    • 关键词:
    • AAA PLUS PROTEASE; CAULOBACTER-CRESCENTUS; CHROMOSOME-REPLICATION;DEGRADATION; PROGRESSION; COMPLEX; PHOSPHORYLATION; SUBSTRATE; CLPXP;STABILITY
    • Jo···, ···al···sh···;B···e,···tt···u;···ha···sh···, ···is···um···Vi···ie···Pa···ck···nr···hi··· P···r
    • 《CE··》
    • 2015年
    • 163卷
    • 2期
    • 期刊

    Re···at···pr···in···gr···ti···is···se···al···he···me···es···ct··· o···ru···l ···te··· b···he···pX···ro···se···iv···ce···cy··· p···re···on··· t···ba···ri···Ca···ba···r ···sc···us···lt···gh···pX···s ···iv···lo··· a···ti···l ···to···ar···ne···ic···y ···ui··· f···ce···cy···-d···nd··· p···eo···is···er···we···ow···at···es···ac···s ···st···te··· a···to···ie···ch···he···n ···fe···t ···st···es···e ···tr···d ···ed··· t···de···e ···ad···or···se···y.···e ···ra···y ···ld···po···ri···g ···Cl··· b···he···ap··· C···, ···ch···om···s ···ra···io···f ··· c···s ···su···ra··· a···al···re···it···he···ap··· R··· t···eg···e ···ec··· c···s ···su···ra···. ···in···he···pA···ap··· p···ot···de···uc···n ···a ···rd···as···f ···st···es···d ···ib··· d···ad···on··· t···se···d ···ss···e ···se···Rc···to···ne···e ···po···ad···or···id···if···g ···ti··· s···tr··· e···en···ne···d ··· R··· r···gn···on···d ···ov···ng···di···na···el···yc···de···de···Cl··· s···tr···s.···r ···k ···ea···ho···ie···ch···l ···pt··· a···pr···d ···te···s ···he···at···eg···te···ro···ly··· d···ng···ct···al···ll···cl···ro···ss···.

    ...
  • 8.A ···sp···ig···in···da···r ···me···he···A+···ot···e ···XP··· D···e ···l ···le···gu···ed···ot···ys···

    • 关键词:
    • 0 / Bacterial Proteins. EC 3.4.21.92 / Endopeptidase Clp. EC 3.6.1.- / Adenosine Triphosphatases
    • La···Jo···e;···na···z-···ce···Li···Va··· R···rt···Ch···, ···er
    • 《Mo···ul···ce··》
    • 2015年
    • 59卷
    • 1期
    • 期刊

    Th···es···se···gu···or···dR···up··· p···ph···la···n ···nt···n ···lo···te···re···nt···wi···th···AA···ro···se···pX···o ···vi···pu···ua··· d···ad···on··· c···ia···ub···at···in···ve···n ···l ···le···gu···io···Cp···fu···io···li···an···ap··· t···lt···su···ra···ch···e ···Cl···; ···ev··· i···em···s ···le···ho···pd···nf···nc···it···ul···le···rg···. ···e ···sh···th··· u···ke···no···al···pX···da···rs···pd···lo···do···no···tr···ly···nd···s ···st···e.···st···, ···R ···ds···e ···er···al···ma···of···pX···d ···pa··· (···me···th···nf···as···or···bs···te···ga···en···Th···pr···ng···ea··· a···cr···me···in···fa···th···do··· m···ip···su···ra··· a···ad···io··· a···to···om···en··· W···ho···ha···da···r-···en···t ···mi···of···pX···oi···co···nt···io···ep···en···nh···ti···th···li···s ···di···na···ca···ld··· a···to··· P···ph···gn···ng···sr···s ··· a···to···ro···se···te···ti··· a···mu···io···in···dR···at···pa···Cl···bi···ng···ne···ap··· a···vi···an···io···ic···fu···io···To···he···th··· r···lt···ev··· h···a ···gl···da···r ··· c···an···lo··· c···ge···n ···te··· c···os···on···ro··· p···in···f ···ro···se···Co···ig···© ···5 ···ev··· I··· A···ri···s ···er···.

    ...
  • 9.Ch···en··· a···dr···s:···ys··· o···ea···nt···ct···s ···en···l ···li··

    • 关键词:
    • PROTEIN-PROTEIN INTERACTIONS; CELL-FREE FORMATION; MACROMOLECULARINTERACTIONS; LIVING CELLS; REVEALS; ROOTS
    • Ch···, ···er···er···h,···la···
    • 《MO···UL···BI···GY··· T···CE··》
    • 2014年
    • 25卷
    • 22期
    • 期刊

    Bi···gi··· s···em···is···y ···nn··· c···ci···s ···se···or···iz···Mo···ve···th··· s···el···ar···ch···ct···s ··· d···mi···nd···sp···iv···o ···ng··· n···s ··· c···it···s.···y ···th··· p···er···s ··· m···fo···we···"q···ar···in···ac···ns···at···ve···ol··· t···re··· s···if···sp···al···tw···s ···ma···mo···ul··· T···e ···ci··· a···ng···nt···f ···ec···s ···bl···ig···s ···be···op···te···ve···is···ce···uc···re···r ···n ···ec···r ···en···ns···re··· p···e ···ar···on···ha···ef··· f···ti···l ···io···in···ll···an···mp···y ···lu··· r···on··· t···ha···s ···th··· e···ro···nt···A ···or···al···ge··· t···ev···p ···ch···ca···oo···an···hy···al···de···to···sc···e ··· p···pl···f ···k ···er···io···op···ti···in···ll···We···so···ed···tt···ap···ac··· t···ea···e ··· b···es··· t···sp···al···st···ut···s ···ce···la···ac···ol···le···ha···es··· f··· t···in···ra··· a···on··· m···ip···we···in···ac···ns···ar···rs···s ···we···ce···bi···gi···, ···ch···st···an···hy···is···ar···eq···ed··· d···oy···es···et···s.···ge···r ···se···pr···he···il···el···s ···li···th···re···of···de···an···g ··· b···og···l ···ue···ha···us···ns···fe··· a···le···ar···d ···lu··· l···l.

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