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Development of preventive strategy for lifestyle-related diseases by activation of circadian clock

项目来源

日本学术振兴会基金(JSPS)

项目主持人

小柳 悟 九州大学, 薬学研究科(研究院), 准教授 (60330932)

项目受资助机构

九州大学

立项年度

2012

立项时间

未公开

项目编号

24650446

项目级别

国家级

研究期限

未知 / 未知

受资助金额

3510000.00日元

学科

未公开

学科代码

未公开

基金类别

挑戦的萌芽研究

关键词

体内時計 / 生活習慣病 / 加齢・老化 / 発がん / 概日リズム / ATF4 / 抗がん剤感受性 / 生体リズム / 概日時計 / 活性化 / 老化 ;

参与者

未公开

参与机构

未公开

项目标书摘要：Dysfunction of circadian clock along with aging is implicated with development of lifestyle-related diseases, such as diabetes, cancers, and cardiovascular diseases. However, there was no preventive strategy for lifestyle-related diseases by activation of circadian clock. In this study, we found that ATF4, a circadian clock-regulatory factor, regulates cellular oncogenic transformation and the sensitivity of tumor cells. In addition, control of the activity of ATF4 enabled to prevent oncogenesis. Since ATF4 was also involved in the regulation of amino acid synthesis and cellular senescence, control of the activity of ATF4 may lead to develop the preventive method for lifestyle-related diseases through activating the circadian clock.

Application Abstract: Dysfunction of circadian clock along with aging is implicated with development of lifestyle-related diseases, such as diabetes, cancers, and cardiovascular diseases. However, there was no preventive strategy for lifestyle-related diseases by activation of circadian clock. In this study, we found that ATF4, a circadian clock-regulatory factor, regulates cellular oncogenic transformation and the sensitivity of tumor cells. In addition, control of the activity of ATF4 enabled to prevent oncogenesis. Since ATF4 was also involved in the regulation of amino acid synthesis and cellular senescence, control of the activity of ATF4 may lead to develop the preventive method for lifestyle-related diseases through activating the circadian clock.

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  • 2.Dietary supplementation with essence of chicken enhances daily oscillations in plasma glucocorticoid levels and behavioral adaptation to the phase-shifted environmental light-dark cycle in mice

    • 关键词：
    • Circadian rhythm; Aging; Jet lag; Glucocorticoids; StAR; EC;CLOCK GENE-EXPRESSION; CIRCADIAN-RHYTHMS; JET-LAG; MOUSE; SYSTEM;ENTRAINMENT; COMPONENTS; DISORDERS; PROTEIN; HEALTH
    • Dilixiati, Adila;Koyanagi, Satoru;Kusunose, Naoki;Matsunaga, Naoya;Ohdo, Shigehiro
    • 《JOURNAL OF PHARMACOLOGICAL SCIENCES》
    • 2017年
    • 134卷
    • 4期
    • 期刊

    Maintenance of circadian rhythms is essential to many aspects of human health, including metabolism and neurological and psychiatric well-being. Chronic disruption of circadian clock function is implicated in increasing the risk of metabolic syndrome, cardiovascular events and development of cancers. However, there are little approaches to reinforce the function of circadian clock for prevention of these diseases. Essence of Chicken (EC) is a nutritional supplement that is traditionally made by extracting water soluble substances derived from cooking the whole chicken. In this study, we found that dietary supplementation with EC enhanced circadian oscillation of glucocorticoid secretion in mice, and this was accompanied by enhancement of circadian oscillation in the adrenal expression of steroidogenic acute regulatory (StAR) protein that mediates the rate-limiting step of glucocorticoid synthesis. Furthermore, EC facilitated re-entrainment of behavioral rhythm in mice when phase of the light-dark cycle was suddenly advanced. These results suggest that intake of EC has enhancement effect on circadian clock function in mice, which may contribute to sustain health and also offer new preventive strategies against circadian-related diseases. (C) 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.

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