项目来源

日本学术振兴会基金(JSPS)

项目主持人

小柳 悟 九州大学, 薬学研究科(研究院), 准教授 (60330932)

项目受资助机构

九州大学

项目编号

24650446

立项年度

2012

立项时间

未公开

研究期限

未知 / 未知

项目级别

国家级

受资助金额

3510000.00日元

学科

未公开

学科代码

未公开

基金类别

挑戦的萌芽研究

关键词

体内時計 / 生活習慣病 / 加齢・老化 / 発がん / 概日リズム / ATF4 / 抗がん剤感受性 / 生体リズム / 概日時計 / 活性化 / 老化 ;

参与者

未公开

参与机构

未公开

项目标书摘要：Dysfunction of circadian clock along with aging is implicated with development of lifestyle-related diseases, such as diabetes, cancers, and cardiovascular diseases. However, there was no preventive strategy for lifestyle-related diseases by activation of circadian clock. In this study, we found that ATF4, a circadian clock-regulatory factor, regulates cellular oncogenic transformation and the sensitivity of tumor cells. In addition, control of the activity of ATF4 enabled to prevent oncogenesis. Since ATF4 was also involved in the regulation of amino acid synthesis and cellular senescence, control of the activity of ATF4 may lead to develop the preventive method for lifestyle-related diseases through activating the circadian clock.

Application Abstract: Dysfunction of circadian clock along with aging is implicated with development of lifestyle-related diseases, such as diabetes, cancers, and cardiovascular diseases. However, there was no preventive strategy for lifestyle-related diseases by activation of circadian clock. In this study, we found that ATF4, a circadian clock-regulatory factor, regulates cellular oncogenic transformation and the sensitivity of tumor cells. In addition, control of the activity of ATF4 enabled to prevent oncogenesis. Since ATF4 was also involved in the regulation of amino acid synthesis and cellular senescence, control of the activity of ATF4 may lead to develop the preventive method for lifestyle-related diseases through activating the circadian clock.