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Predoctoral Training Program in Genetics

项目来源

美国卫生和人类服务部基金(HHS)

项目主持人

BENDER, MICHAEL T

项目受资助机构

YALE UNIVERSITY

立项年度

2019

立项时间

未公开

项目编号

5T32GM007499-42

研究期限

未知 / 未知

项目级别

国家级

受资助金额

667258.00美元

学科

Health Disparities; Minority Health;

学科代码

未公开

基金类别

TRAINING, INSTITUTIONAL

关键词

未公开

参与者

CARLSON, JOHN R; REINKE, VALERIE J

参与机构

NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

项目标书摘要：This proposal is to continue NIH support for predoctoral training within the interdepartmental Training Program in Genetics (TPG) of Yale University. In a typical year, there are ~35-40 TPG trainees, of which the TPG financially supports 14 2nd and 3rd year students. Sixty-five faculty are TPG trainers. The principal administrative and training entities are within three departments: the departments of Molecular, Cellular and Developmental Biology (MCDB) and Ecology and Evolutionary Biology (EEB) in the FAS, and Genetics at the Yale Medical School. The program, which is overseen by two co-Directors, Valerie Reinke and John Carlson, supports training in all aspects of modern genetics. Candidate students enter Yale via application to either the umbrella program Biological and Biomedical Sciences (BBS) or to the EEB department. At the end of year 1, students with a research interest in genetics and who are in the lab of participating TPG faculty fill out a formal application to join the TPG. The TPG advisory panel reviews the applications and selects the most appropriate student to be appointed to the TPG. The TPG has multiple training activities, including an annual student-organized symposium, a research-in- progress seminar series, and various workshops for scientific and career development. Importantly, multiple training initiatives specific to this program have been added during the last funding period, including a TPG retreat, an outside speaker seminar series, and additional mentoring for both trainees and junior faculty trainers. All students perform at least one-year of supervised teaching and receive travel funds to attend and present their work at national or international scientific meetings. All TPG students are mentored by the TPG directors, in addition to their thesis committee. Starting in fall 2011, the students received full institutional support (stipend, tuition and health benefits) from Yale during their first year, which includes formal course work and three research rotations. The majority of graduates go on to leading positions in academic and research institutions or in biotechnology and pharmaceutical companies.

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  • 1.Thin Skinned: Aged Adipocyte Atrophy Impacts Innate Immunity

    In a recent study, Zhang et al. (Immunity 2019; 50: 121-136) report that adipocyte atrophy in aged skin increases susceptibility to bacterial infection. Enhanced TGF-beta signaling in aged adipocyte progenitor cells induces a fibrotic cell fate that lacks antimicrobial peptides produced by mature adipocytes, highlighting the importance of stromal cells as innate immune effectors.

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  • 2.The diverse small proteins called odorant-binding proteins

    • 关键词：
    • odorant-binding protein; olfaction; antenna; Drosophila; insect;PHEROMONE-BINDING; DROSOPHILA-MELANOGASTER; CHEMOSENSORY PROTEINS;OLFACTORY ORGANS; GENE FAMILY; BOMBYX-MORI; EXPRESSION; MOTH; RECEPTORS;TASTE

    The term 'odorant-binding proteins (Obps)' is used to refer to a large family of insect proteins that are exceptional in their number, abundance and diversity. The name derives from the expression of many family members in the olfactory system of insects and their ability to bind odorants in vitro. However, an increasing body of evidence reveals a much broader role for this family of proteins. Recent results also provoke interesting questions about their mechanisms of action, both within and outside the olfactory system. Here we describe the identification of the first Obps and some cardinal properties of these proteins. We then consider their function, discussing both the prevailing orthodoxy and the increasing grounds for heterodox views. We then examine these proteins from a broader perspective and consider some intriguing questions in need of answers.

    ...

  • 3.The diverse small proteins called odorant-binding proteins

    • 关键词：
    • odorant-binding protein; olfaction; antenna; Drosophila; insect;PHEROMONE-BINDING; DROSOPHILA-MELANOGASTER; CHEMOSENSORY PROTEINS;OLFACTORY ORGANS; GENE FAMILY; BOMBYX-MORI; EXPRESSION; MOTH; RECEPTORS;TASTE

    The term 'odorant-binding proteins (Obps)' is used to refer to a large family of insect proteins that are exceptional in their number, abundance and diversity. The name derives from the expression of many family members in the olfactory system of insects and their ability to bind odorants in vitro. However, an increasing body of evidence reveals a much broader role for this family of proteins. Recent results also provoke interesting questions about their mechanisms of action, both within and outside the olfactory system. Here we describe the identification of the first Obps and some cardinal properties of these proteins. We then consider their function, discussing both the prevailing orthodoxy and the increasing grounds for heterodox views. We then examine these proteins from a broader perspective and consider some intriguing questions in need of answers.

    ...
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