项目来源

美国卫生和人类服务部基金(HHS)

项目主持人

未公开

项目受资助机构

FRED HUTCHINSON CANCER RESEARCH CENTER

项目编号

5R01CA018105-10

立项年度

1985

立项时间

未公开

项目级别

国家级

研究期限

未知 / 未知

受资助金额

未知

学科

未公开

学科代码

未公开

基金类别

未公开

关键词

未公开

参与者

APPELBAUM, FREDERICK R

参与机构

NATIONAL CANCER INSTITUTE

项目标书摘要：We plan to continue to develop and assess the efficacy of novel approaches for the treatment of malignant disease based on studies in dogs with spontaneously occurring malignancies. Studies in dogs with malignant lymphoma have shown that some dogs treated with chemotherapy, total body irradiation (TBI) and autologous marrow infusion can be cured of their disease but that most will ultimately develop recurrent lymphoma. We propose to determine whether recurrent lymphoma results from infusion of malignant cells in the autologous marrow or from failure of TBI to eradicate all malignant cells. We will investigate the mechanism of cure in dogs free of disease after therapy by determining whether such dogs are immune to autologous lymphoma cells. We also plan to study the graft-versus-tumor effect of allogeneic marrow transplantation using a new immunosuppressive agent, cyclosporin A. In dogs with osteogenic sarcoma, we wish to test the hypothesis that growth of metastatic tumor can be inhibited by interference with hemostatic mechanisms. We also plan to assess whether the results of in vitro assays of cell-mediated and humoral immunity performed serially before and after amputation in dogs not given adjuvant chemotherapy correlate with in vivo events. We also will compare the effectiveness of conventional versus high dose methotrexate as cytoreductive chemotherapy administered before amputation. We also plan to study the feasibility and effectiveness of positron emission tomography in tumor imaging.