以前研究表明药剂诱导褐飞虱雄虫的生殖效应经交配使雌虫产生显著的交配后效应。但调控雌虫交配后效应的途径及其作用机理不清楚。申请者前期研究发现NlAC9基因表达与雌虫产卵有关，交配的雌虫卵巢内章鱼胺(OA)含量显著增加。基于昆虫OA生理功能及其信号传导的研究进展，我们提出了“OA响应交配介导cAMP/PKA信号通路调控褐飞虱生殖”的假设。本项目拟在前期研究基础上采用RNAi干扰、生物测定、Western blot和免疫荧光等方法，解析褐飞虱雌虫体内OA信号对交配的响应机理，探明OA及Octβ2R受体对雌虫生殖

装机容量的不断增长和叶轮直径的增大对限制风力机噪声等级提出了新的要求。风力机气动噪声可细化为近场气动噪声源机理研究和远场噪声传播研究。观测表明，在一定的大气湍流强度，湿度和温度梯度下，风力机噪声可对周边几百至几千米范围产生影响。本项目基于前期对噪声源方面的研究基础，提出气动噪声源结合远距离传播的新概念。风力机气动噪声源的数值模拟建立在计算气动声学(CAA)的基础上。声源的模拟结果将作为输入参量引入到传播模型的计算域。采用抛物线方程(PE)的方法，在给定的计算空间，得到各个频率段的声压等级分布。大气湍流和地

Mitochondrial and synaptic dysfunction is an early pathological feature of Alzheimer's disease (AD) affected brain. The underlying mechanisms and strategies to repair it remain unclear. Recent studies have highlighted the role of mitochondrial A� and earl

PROJECT SUMMARY This proposal seeks support for 14 postdoctoral fellows for a two year training curriculum within an established and highly successful program (Interdisciplinary Training in Cancer Model Systems ? ITCMS) that instills interdisciplinary ap

nnotation:The project is aimed at solving the problems of developing high-speed land transport,improving the design of ejection rocket launchers(rocket tracks)used in ground testing of aviation and rocket technology.In the course of its implementation,it

nnotation:The solution of wave problems is necessary for a wide range of practical applications in such fields as ultrasonic non-destructive testing,wave monitoring of the state of aerospace products,evaluation and prediction of the state of engineering