研究三维条件下岩石材料中缺陷的演化规律及其导致岩石材料最终失效或破坏的机理，是岩石力学研究中的难题。本项目围绕三维矿岩颗粒破裂过程中宏细观力学行为的结构效应展开研究，通过实验室试验、理论分析与数值试验相结合的方法，探讨三维矿岩颗粒的破碎机理。首先对典型矿岩颗粒介质进行三维结构重建，开发与完善三维不规则矿岩颗粒破裂分析数字图像处理技术，建立基于真实细观结构的三维数值模型；在数值试验的基础上，探讨三维不规则矿岩颗粒在不同外部形状、不同内部结构、不同介质均匀性、不同外载荷作用的破裂机制；基于数值试验和矿岩颗粒破

间歇反应与精馏强化技术，通过反应能力与分离能力相互协同作用，可有效提高资源/能源利用率，减少污染。课题根据间歇反应精馏过程多时序、强耦合、非线性特性，研究基于两维(批次+时间)动态信息的实时优化操作与动态协同控制方法，拟解决废液循环利用的批间优化操作与生产调度问题。内容如下:1)建立间歇反应精馏动态数学模型，研究强化过程物料转化与能量利用机制，设计经济集成优化算法获取反应与分离能力最佳匹配的集成结构。2)研究基于经济模型的动态优化与控制协同算法，实现最佳操作轨迹、最短生产周期与跟踪控制同步优化；研究基于批

? DESCRIPTION (provided by applicant): The long-term aim of this project is to enable the imaging of vesicle and organelle dynamics inside living cells with unprecedented spatial and temporal resolution. The most compelling advantage of new super-resol

DESCRIPTION (provided by applicant): Kinase inhibitors created a new paradigm in chemotherapy and are a major focus of new oncology drug development, but developmental success rates are low (5-10%). Resistance to kinase inhibitors occurs through target-de

nnotation:The ongoing global processes increase the importance of the Arctic region,which in the coming years may acquire the status of a new European-Asian transit line,as well as become the most important mining region of Russia.At the same time,develo

nnotation:The solution of wave problems is necessary for a wide range of practical applications in such fields as ultrasonic non-destructive testing,wave monitoring of the state of aerospace products,evaluation and prediction of the state of engineering