奈米级聚合体於检测、传输与调控之开发与应用

项目来源

台(略)府(略)金(略)B(略)

项目主持人

黄(略)

项目受资助机构

台(略)华(略)医(略)环(略)系

项目编号

N(略)9(略)1(略)0(略)0(略)M(略)

财政年度

2(略),(略)0

立项时间

未(略)

研究期限

未(略) (略)

项目级别

省(略)

受资助金额

4(略).(略)元(略)

学科

化(略)

学科代码

未(略)

基金类别

基(略)/(略)助

关键词

适(略);(略)金(略)化(略) (略)制(略);(略)效(略)

参与者

未(略)

参与机构

未(略)

项目标书摘要:适合(略)利用指数富集的配基(略)atic evol(略)gands by (略) enrichme(略),筛选出能与目标物(略) 或 RNA 片段(略)兼具与抗体相似的分(略)的 DNA 结构亦(略)、价格便宜、运送过(略)长期保存、分子量小(略)易引起免疫反应等优(略)ELEX 筛选出能(略)构差异的适合体,并(略)和力,此外,若适合(略)细胞膜上有大量表现(略)侦测灵敏度下降,不(略)胞标记与标靶性药物(略)究计划将适合体与奈(略)米材料提供的诸多优(略)断和癌症治疗应用上(略)中,我们计划开发一(略)基材,并将此材料与(略)筛选出能辨识特定肿(略)用适合体修饰奈米粒(略)(multival(略)tion),增强药(略)结合能力。此外,我(略)奈米棒具有的光热转(略)雷射来调控材料表面(略)改变,适时控制药物(略)性药物影响其他正常(略)用贵重金属奈米粒子(略)测药物释放的情形。(略)光"应答控制药物释(略)放行为之多功能性药(略)物治疗的协同作用下(略)果效,降低癌症复发(略)以"环境"应答机制(略)性应答型高分子复合(略)分子"之检测、回收(略)辨识不同目标物的特(略)NAzyme 等功(略)联网络的高分子水凝(略)子的专一选择性。同(略)的结合,改变高分子(略)产生溶胶—凝胶结构(略)分子如重金属污染物(略)型复合材料,达到灵(略)控管污染水源的目的(略)

Applicati(略): The dev(略) cell-bas(略)thods all(略)on of apt(略) the fiel(略)tion and (略)cancer ce(略)geted the(略)cer.Due t(略)que prope(略)as the ea(略)esis and (略)n,small s(略)ck of imm(略),aptamers(略)ed as a p(略)ss of lig(略)ecific bi(略)targeting(略)val the m(略)her molec(略),such as (略)However,t(略)me obstac(略)imit thei(略)ies for s(略)tection o(略)lls and t(略)g deliver(略)le,some o(略)ted aptam(略) weak bin(略)ty and on(略)ity targe(略)proteins (略)cer cells(略) in their(略)lopmental(略)order to (略)ese short(略)proposed (略)gold-base(略)as scaffo(略)mble mult(略)rs,and th(略) the bind(略)y trough (略) interact(略)nsitive a(略)e cancer (略)nition.Th(略)absorptio(略)ar infrar(略)ill also (略)fficient (略)l convect(略)t generat(略)ring the (略)a nanorod(略)rmal-sens(略) polymer,(略)ded drugs(略)be releas(略)trollable(略)ing a nea(略)laser.The(略)vantages (略)ltiple fu(略)es makes (略)ed inorga(略) nano-hyb(略) promisin(略)ted drug (略)th minimu(略)cts.The s(略)f this pr(略)o constru(略)corporate(略)system fo(略) sensing (略)g heavy m(略)inants in(略)pollution(略)ign,DNA a(略)DNAzymes (略)ecularly (略)into the (略)polymer c(略)oss-linke(略)ence of t(略)ules will(略)ir crossl(略)ity to tr(略)o-gel or (略)transitio(略)the gel s(略) recycled(略)tions of (略) chemical(略)or by inc(略) temperat(略)he meltin(略)re of dou(略)DNA cross(略)us,target(略) hydrogel(略)rgo physi(略)changes i(略)to molecu(略),such as (略) contamin(略)omising m(略)r low cos(略) tools fo(略)er qualit(略)t.

项目受资助省

台(略)

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