Defining the Role of Mitochondrial Dysfunction in Autism Spectrum Disorder

项目来源

德(略)基(略)F(略)

项目主持人

L(略)a(略)R(略)s(略)a(略)

项目受资助机构

J(略)n(略) (略)e(略)r(略)n(略)r(略)ä(略)a(略),(略)v(略)i(略)s(略)i(略),(略)t(略)t(略)r(略)l(略)l(略) (略)i(略)

项目编号

4(略)0(略)3

立项年度

2(略)

立项时间

未(略)

研究期限

未(略) (略)

项目级别

国(略)

受资助金额

0(略)欧(略)

学科

B(略)o(略)a(略)s(略)i(略)y

学科代码

未(略)

基金类别

W(略)P(略)t(略)

关键词

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参与者

L(略)a(略)R(略)s(略)a(略), Ph.D.

参与机构

未(略)

项目标书摘要:ut(略)m Disorde(略) incurabl(略)ic disord(略)ects beha(略)mmunicati(略)entation (略)ighly het(略)and its i(略) increasi(略)s in SH3 (略)e ankyrin(略)ains prot(略)3)and fra(略)al retard(略)1),protei(略) in synap(略)y,increas(略)of develo(略)tochondri(略)nt in the(略)rforming (略)asks not (略)ated with(略)duction a(略)lation of(略)gnaling.R(略)rch has d(略) that the(略)of mitoch(略)teins occ(略)synapse,c(略) to susta(略)tic activ(略),few stud(略)dressed i(略)w mitocho(略)irments i(略)n differe(略)gions and(略)ly in the(略)n prelimi(略)how diffe(略)xygen con(略) mouse mo(略) with the(略)phenotype(略)iatum,an (略)rain stru(略)ved in mo(略)ion plann(略)n-making,(略)and rewar(略)und incre(略)trations (略) oxidativ(略)n the str(略)D mice,de(略) an alter(略)vironment(略) brain.In(略)ct,I plan(略)itochondr(略)tion and (略)ications (略) proteins(略)iatum of (略)nd Fmr1 K(略)larify th(略)itochondr(略)tion on s(略)ivity in (略)odels.Mit(略)shape,res(略)d ATP gen(略)l be eval(略)riatal ti(略)imary str(略)res.Here,(略)physiolog(略) to eluci(略)r ASD res(略)nges in t(略)e and red(略)tions of (略)oteins.My(略)ll provid(略)hts into (略)anding of(略)en up nov(略)ives in d(略)ffective (略)

Applicati(略): Autism (略)sorder(AS(略)urable ps(略)isorder t(略) behavior(略)ication.T(略)tion of A(略)y heterog(略)its incid(略)reasing.M(略) SH3 and (略)kyrin rep(略) protein (略)d fragile(略)etardatio(略)roteins i(略)synaptic (略)crease th(略)eveloping(略)ondria ar(略)n the syn(略)ming diff(略) not only(略) with ene(略)ion and t(略)on of cal(略)ing.Recen(略)has demon(略)t the syn(略)itochondr(略)s occurs (略)pse,contr(略)sustainin(略)activity.(略) studies (略)sed in de(略)tochondri(略)nts impac(略)fferent b(略)s and spe(略)n the syn(略)eliminary(略)differenc(略)n consump(略)se models(略)h the str(略)otype in (略)m,an impo(略) structur(略)in motor (略)planning,(略)king,moti(略)reward.I (略)increased(略)ions of r(略)dative sp(略)e striatu(略)ce,demons(略)altered r(略)nment in (略)in.In thi(略) plan to (略)hondrial (略) and redo(略)ions of s(略)teins in (略)m of Shan(略)mr1 KO mi(略)fy the ro(略)hondrial (略) on synap(略)y in ASD (略)s.Mitocho(略)e,respira(略)P generat(略) evaluate(略)al tissue(略)y striata(略)Here,I wi(略)iological(略)elucidate(略)D results(略) in the a(略)d redox m(略)s of syna(略)ns.My stu(略)rovide ne(略)into the (略)ng of ASD(略)p novel p(略) in devel(略)tive trea(略)

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