肿瘤细胞微尺度电阻抗成像检测与免标记高速分离方法研究
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1.Artificial Sensitive Skin for Robotics Based on Electrical Impedance Tomography
- 关键词:
- artificial sensitive skin; electrical impedance tomography; human-robotinteractions; robotics; tactile sensors;POLYMER TACTILE SENSOR; IMAGE-RECONSTRUCTION; PRESSURE SENSORS;OPTICAL-FIBER; FORCE; SYSTEM; MATRIX; FILMS; ARRAY
Electrical impedance tomography (EIT) is a noninvasive measurement technique that estimates the internal resistivity distribution based on the boundary voltage-current data measured from the surface of the conductor. If a thin stretchable soft material with a certain piezoresistive property is used as the electrical conductor, EIT has the ability to reconstruct the position where the resistivity changes due to the inside pressure contact, so that a large-scale artificial sensitive skin is provided for robotics. First, the different conduction principles and material types of artificial sensitive skins are discussed, which is next followed by the different driving modes and image reconstruction techniques. Then, details on how EIT is used for robotic skin applications are described. Finally, the development trends and future potentials of EIT-based robotic skins are expounded.
...2.Evaporative characteristics of sessile nanofluid droplet on micro-structured heated surface.
- 关键词:
- 7782-42-5 / Graphite;
Micro-structure patterned substrates attract our attention due to the special and programmable wettabilities. The interaction between the liquid and micro/nano structures gives rise to controllable spreading and thus evaporation. For exploration of the application versatility, the introduction of nanoparticles in liquid droplet results in interaction among particles, liquid and microstructures. In addition, temperature of the substrates strongly affects the spreading of the contact line and the evaporative property. The evaporation of sessile droplets of nanofluids on a micro-grooved solid surface is investigated in terms of liquid and surface properties. The patterned nickel surface used in the experiments is designed and fabricated with circular and rectangular shaped pillars whose size ratios between interval and pillars is fixed at 5. The behavior is firstly compared between nanofluid and pure liquid on substrates at room temperature. For pure water droplet, the drying time is relatively longer due to the receding of contact line which slows down the liquid evaporation. Higher concentrations of nanoparticles tend to increase the total evaporation time. With varying concentrations of graphite at nano scale from 0.02% to 0.18% with an interval at 0.04% in water droplets and the heating temperature from 22 to 85°C, the wetting and evaporation of the sessile droplets are systematically studied with discussion on the impact parameters and the resulted liquid dynamics as well as the stain. The interaction among the phases together with the heating strongly affects the internal circulation inside the droplet, the evaporative rate and the pattern of particles deposition. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
...3.Actuation of adaptive liquid microlens droplet in microfluidic devices: A review
- 关键词:
- Adaptive lens; Electro-microfluidics; Liquid actuation; Microfluidics;Profile deformation;POLYMER GELS; LENS; ARRAYS; CHIP; PRINCIPLE; MICROCHIP; DESIGN; FUTURE
A significant growth of research on adaptive liquid lens is achieved over the past decades, and the field is still attracting increasing attentions, focusing on the transition from the current stage to the commercialized stage. The challenges faced are not limited to fabrication, material, small tuning range in focal lengths, additional control systems, limitations in special actuation methods and so on. In addition, the use of external driving parts or systems induce extra problem on bulky appearance, high cost, low reliability etc. Therefore, adaptive liquid lens will be an interesting research focus in both microfluidics and optofluidics science. This review attempts to summarize and focus on the droplet profile deformation under different driving mechanisms in tunable liquid microlens as well as the application in cameras, cell phone and so on. The driving techniques are generally categorized in terms of mechanisms and driving sources.
...4.Microfluidic device embedding electrodes for dielectrophoretic manipulation of cells-A review
- 关键词:
- Cell manipulation; Dielectrophoresis; Electrode pattern; Microfluidics;CIRCULATING TUMOR-CELLS; SINGLE-CELL; FLUID-FLOW; PARTICLE SEPARATION;DOUBLE-LAYER; CHIP; SYSTEM; MICROELECTRODES; ELECTROLYTES; RESISTANCE
Microfluidic device embedding electrodes realizes cell manipulation with the help of dielectrophoresis. Cell manipulation is an important technology for cell sorting and cell population purification. Till now, the theory of dielectrophoresis has been greatly developed. Microfluidic devices with various arrangements of electrodes have been reported from the beginning of the single non-uniform electric field to the later multiple physical fields. This paper reviews the research status of microfluidic device embedding electrodes for cell manipulation based on dielectrophoresis. Firstly, the working principle of dielectrophoresis is explained. Next, cell manipulation approaches based on dielectrophoresis are introduced. Then, different types of electrode arrangements in the microfluidic device for cell manipulation are discussed, including planar, multilayered and microarray dot electrodes. Finally, the future development trend of the dielectrophoresis with the help of microfluidic devices is prospected. With the rapid development of microfluidic technology, in the near future, high precision, high throughput, high efficiency, multifunctional, portable, economical and practical microfluidic dielectrophoresis will be widely used in the fields of biology, medicine, agriculture and so on.
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