项目来源
国家重点研发计划(NKRD)
项目主持人
魏文强
项目受资助机构
中国医学科学院肿瘤医院
项目编号
2016YFC0901400
立项年度
2016
立项时间
未公开
研究期限
未知 / 未知
项目级别
国家级
受资助金额
1835.00万元
学科
精准医学研究
学科代码
未公开
基金类别
精准医学研究重点专项
关键词
食管癌 ; 癌前病变 ; 高发区 ; 筛查 ; Esophageal cancer ; Precancerous lesions ; high risk areas ; screening
参与者
陈茹
参与机构
北京市肿瘤防治研究所；汕头大学医学院
项目标书摘要：本课题旨在依据统一的高发现场食管癌及其癌前病变人群队列建立标准规范，建立覆盖人群不少于10万人的前瞻性人群队列。收集人群流行病学基线调查信息、病理诊断信息和治疗随诊信息，采集血液、病变组织等生物样本，建立生物样品库和与之对应的数据信息库，为精准医学重大专项食管癌专病研究共享平台的搭建提供资源。目前，本课题已制定了9个高发区人群队列相关标准规范，出版了《上消化道癌筛查及早诊早治技术方案(2020年试行版)》,编制了《食管癌专病队列数据集》团体标准已正式送审。在8个高发区构建前瞻性队列121503人，收集队列人群的流行病学调查信息，同时收集内镜和病理诊断等诊断信息，并与调查信息进行链接。建成了以林州为中心样本库，磁县、扬中、肥城、盐亭、北肿和汕头为分中心的生物样本库。样本库建筑面积超过1200平方米，配备-80℃超低温冰箱28台，收集血液标本62808例，组织标本39041例，样本信息与流行病学调查信息以唯一编码相链接。在主动随访基础上，依托全国肿瘤登记中心平台，以二代身份证作为个体识别信息，在全国肿瘤登记系统中对队列人群的食管癌发病情况和人群生存情况进行追踪和调查，比对发病和死亡信息，完善随访数据，建立主动随访和被动随访相结合的高效动态随访体系，使随访率达到90%以上。建立食管癌专病队列研究项目数据管理平台，为食管癌防控研究提供了丰富的数据和样本资源。
Application Abstract: This project aims to establish standards for the cohort of esophageal cancer and its precancerous lesions in high-risk areas and establish a prospective cohort that covers a population of no less than 100,000.To collect epidemiological baseline survey information,pathological diagnosis information and treatment follow-up information,and to collect blood and tissue samples to establish a biobank with corresponding database.And to provide resources for the establishment of a shared platform for precision medicine of esophageal cancer research.At present,this project has formulated 9 standards related to esophageal cancer cohort in high-risk areas,published the"Upper Gastrointestinal Cancer Screening and Early Diagnosis and Treatment Technical Program(Trial Version in 2020)",and formulated the group standard of"Esophageal Cancer Special Disease Cohort Data Set"that has been formally submitted for review.This project constructed a prospective cohort of 121,503 subjects from 8 high risk areas,and collected their epidemiological survey information,as well as endoscopic diagnostic information and pathological diagnosis at the same time,and linked with each other.A biological sample bank with Linzhou as the center sample bank and Cixian,Yangzhong,Feicheng,Yanting,Beizhong and Shantou as the sub-centers has been established.The sample library has a building area of over 1,200 square meters,equipped with 28-80℃ ultra-low temperature refrigerators,collecting 62,808 blood samples and 39,041 tissue samples.The sample information and epidemiological survey information are linked with a unique code.On the basis of active follow-up,relying on the platform of the National Cancer Registry,using the second-generation ID card as individual identification information,the incidence death information was compared,and the survival of the cohort populations are tracked and investigated in the national cancer registry to improve the follow-up data,and to establish an efficient and dynamic follow-up system that combines active follow-up and passive follow-up,so that the follow-up rate can reach more than 90%.This project also establish a data management platform for esophageal cancer and provides a wealth of data and sample resources for esophageal cancer prevention and control research.
项目受资助省
北京市
项目实施周期（年）
5
