＜正＞目的眼外肌手术量的准确性是斜视手术成功的关键,仅中国就有成百万的斜视患者需接受手术治疗。建立考虑眼眶悬挂组织（简称眼眶组织）的眼球运动模型,对确定眼外肌手术量具有重要的理论价值和临床实际意义。目前只有含眼外肌的眼眶组织的阻力和刚度数据,不含眼外肌的眼眶组织的阻力和刚度还未见诸报道,后者对眼球运动建模的精确性至关重要。方法以兔为实验动物模型研究含/不含眼外肌的眼眶组织的阻力和刚度。通过在体拉伸实验测量眼球水平运动时含上、下直肌和上、下斜肌4条眼外肌的眼眶组织的阻力和刚度;测量眼球垂直运动时含内、外直肌和上、下斜肌这4条眼外肌的眼眶组织的阻力和刚度;测量不含眼外肌的眼眶组织的阻力和刚度。

＜正＞目的探索骨结构-骨单元宏细观尺度下的液流信号的传导行为。方法利用COMSOL Multiphysics软件建立了含有骨结构、骨内膜、骨外模、骨单元、间质组织、粘合线等功能单元的多孔弹性有限元模型。分析各个功能单元的液体压力,液体流速,应力和应变的变化规律。结果整体骨结构层次上孔隙压力和液体流速由骨内膜沿着骨组织半径到骨外膜有增大的趋势;应力和应变在整体骨组织上分布比较平均,且间隙组织上的Von Mises应力大于

＜正＞目的宇航员和飞行员在日常训练中需要承受长期的高G载荷,目前的基于动物模型的研究主要集中于时间较短、G值较低的水平,因此有必要对长期高G环境下的骨组织进行研究。方法以高加速度模拟高G环境,选取3月龄Wistar大鼠,分为空白组、4 G组、8 G组、10 G组、20 G组,进行3 min/d,为期4周的加载（n=4）,保持加载时间和加速率一致。加载结束后对大鼠进行取血、解剖,取股骨扫描。在蛋白、基因和组织形态检测骨形成和骨

Immunotherapy is a significant method of tumor treatment. It is necessary to investigate the underlying mechanism of the complicated tumor-immune interaction to enhance the effectiveness of immunotherapy. In this study, a tumor cell-immune system model is developed to probe the role of cell-cell adhesion on immune response of tumor cells at different early stages of tumor growth with different initial number of tumor cells. The modeling results exhibit at the small initial number of tumor cells, tumor cells could be totally killed at one time under conditions of both low and high cell-cell adhesion. At the large initial number of tumor cells, the number of tumor cells with high adhesion experiences two drastic fluctuation, while low cell-cell adhesion allows tumor cells to show one obvious fluctuation and one weaker fluctuation. The distinctions in the immune-tumor cells interaction could be interpreted from the point view of distribution pattern of tumor cells and their secreted antigens. These findings may further interpret the potential factors to boost the immune system and provide powerful theoretical foundation for the clinical treatment.
© 2019 IEEE.

Immunotherapy is a significant method of tumor treatment. It is necessary to investigate the underlying mechanism of the complicated tumor-immune interaction to enhance the effectiveness of immunotherapy. In this study, a tumor cell-immune system model is developed to probe the role of cell-cell adhesion on immune response of tumor cells at different early stages of tumor growth with different initial number of tumor cells. The modeling results exhibit at the small initial number of tumor cells, tumor cells could be totally killed at one time under conditions of both low and high cell-cell adhesion. At the large initial number of tumor cells, the number of tumor cells with high adhesion experiences two drastic fluctuation, while low cell-cell adhesion allows tumor cells to show one obvious fluctuation and one weaker fluctuation. The distinctions in the immune-tumor cells interaction could be interpreted from the point view of distribution pattern of tumor cells and their secreted antigens. These findings may further interpret the potential factors to boost the immune system and provide powerful theoretical foundation for the clinical treatment. © 2019 IEEE.

目的建立骨单元到骨细胞的多尺度有限元模型,量化流体力学信号的传递机制,评估骨细胞、骨小管、骨陷窝等功能单元的力传导能力。方法 利用Comsol Multiphysics软件建立了包含骨细胞,骨细胞突触,骨小管和骨陷窝等微观结构的二维多孔弹性力学有限元模型,分析了它们的压力,流速,应力以及应变的分布情况,并得到了骨细胞在不同形状（椭圆、圆形）,不同生长方向（水平、竖直）以及不同力学性能（弹性模量、泊松比、渗透率）下的液流刺激信号的传导规律。结果 （1）相比于骨细胞胞体,骨陷窝和骨小管来说,骨细胞突触感受力学信号的能力最强。

＜正＞目的利用聚乙烯醇（PVA）良好的生物相容性、亲水性、力学性能,海藻酸钠（SA）的黏性、无毒副作用以及纳米羟基磷灰石（n-HA）的类骨成分、可降解性能,将三者复合得到性能良好的复合水凝胶。方法以n-HA为无机相,与PVA及SA复合形成溶胶;再以CaCl2和硼酸为交联剂,循环冷冻解冻,使其具有互穿网络结构,制备PVA/SA/n-HA复合水凝胶。通过冷冻干燥制备多孔支架,利用SEM观察凝胶内部的互穿网络结构,通过FTIR、XRD分析交联情况。将水凝胶与MG63共培养,通过MTT研究水凝胶表面细胞增殖情况,SEM观察细胞在其表面的生长形态,荧光

＜正＞目的探索骨结构-骨单元宏细观尺度下的液流信号的传导行为。方法利用COMSOL Multiphysics软件建立了含有骨结构、骨内膜、骨外模、骨单元、间质组织、粘合线等功能单元的多孔弹性有限元模型。分析各个功能单元的液体压力,液体流速,应力和应变的变化规律。结果整体骨结构层次上孔隙压力和液体流速由骨内膜沿着骨组织半径到骨外膜有增大的趋势;应力和应变在整体骨组织上分布比较平均,且间隙组织上的Von Mises应力大于

Objective The surface modification has been progressed into actively guiding bone tissues reconstruction from passively adopted to the healing of surrounding tissues. Additionally, the effect of surface modification has been developed from micron scale into nanoscale. Nano-coating on implant surface can form a highly similar three-dimensional rough nano surface between the surface of implant and bone tissues. This can be directly used to regulate function of cells surrounding the implant and improve the early osseointegration with good me-

＜正＞目的宇航员和飞行员在日常训练中需要承受长期的高G载荷,目前的基于动物模型的研究主要集中于时间较短、G值较低的水平,因此有必要对长期高G环境下的骨组织进行研究。方法以高加速度模拟高G环境,选取3月龄Wistar大鼠,分为空白组、4 G组、8 G组、10 G组、20 G组,进行3 min/d,为期4周的加载（n=4）,保持加载时间和加速率一致。加载结束后对大鼠进行取血、解剖,取股骨扫描。在蛋白、基因和组织形态检测骨形成和骨