恶性···癌症···前难···的疾···性肿···限增···强的···性是···的主···,严···害着···命健···环肿···（C···）是···年来···用的···几个···瘤分···物之···用于···测,···预后···但是···体分···的临···因为···胞的···表达···性和···而受···。近···着纳···技术···以及···程学···步完···多纳···的研···逐步···生物···环境···多个···已有···明特···比的···构生···底表···究细···并设···的设···制细···的有···工具···和纳···基底···相互···以模···的生···的微···而微···的力···的改···胞的···为之···着一···。因···必要···解纳···的结···纳米···胞生···中的···系,···利用···的特···论文···离子···术制···种不···的纳···阵列···eL···为例···了不···特性···米阵···癌细···能力···,实···限元···据显···究中···两种···森林···对细···不同···性的···应,···生不···刺激···评价···与癌···间的···用对···活性···胞行···响,···明硅···林阵···了H···细胞···态和···为,···基底···CW···比普···增大···3倍···捕获···并且···20···%细···效率···通过···白V···ul···表达···基底···间的···合作···果表···W基···nc···n的···量是···的1···2倍···本研···Vi···li···表达···W基···细胞···力并···细胞···为的···因。···述,···构可···分离···s的···的方···与表···物的···CT···大小···本文···的一···纳米···貌的···阵列···强与···间的···用,···不另···捕获···情况···细胞···率,···以提···的生···性,···获细···性,···捕获···后续···征。···究采···了一···的纳···,为···改善···获效···有用···,这···米基···床应···症治···了一···。

钛（···凭借···异的···广泛···牙科···假体···腔种···取得···的效···Ti···在广···床应···面临···难以···问题···起来···三方···一,···料本···生物···在体···整合···慢,···面制···磷灰···A）···提高···植体···性较···决办···涂层···结合···的问···难以···其二···植者···身体···佳（···糖尿···质疏···）的···,在···面处···量活···RO···会严···骨整···至引···等问···三,···程中···物感···也是···入失···高的···因之···对以···,本···过对···植体···面改···高其···能,···三种···涂层···统研···涂层···机理···研究···下:···通过···化和···理在···面制···层与···合牢···化钛···O2···管阵···后通···处理···管表···了钛···Ca···O3···Ca···化学···方式···了纳···上,···过磷···理形···基底···键合···HA···结果···所制···A涂···iO···管层···固,···良好···相容···促成···增殖···的能···2）···予种···氧化···本研···了具···氧化···单宁···）。···修饰···O2···涂层···箔在···氯化···a ···）溶···泡,···低温···在表···了T···a络···并进···磷酸···中诱···了H···A复···。结···,H···A涂···氧化···出,···容性···具有···细胞···粘附···。（···赋予···抗氧···的基···为了···改善···的抗···,本···入了···g）···粒作···剂。···过T···附了···的T···纳米···和内···出均···的A···颗粒···先后···A-···Cl···及磷···Na···4）···其表···成了···A/···层,···备出···HA···复合···结果···该复···赋予···体良···菌性···氧化···及生···。

进入···纪以···国的···速发···们的···到质···,人···行速···来越···市的···来越···由此···带来···损伤···增加···完全···交通···落伤···为人···的主···,并···事故···造成···损伤···脊柱···主要···从我···脊髓···据库···以发···落造···柱损···为2···而交···造成···损伤···%。···研究···冲击···用下···特性···要,···脊柱···防护···提供···学依···而开···文的···作,···研究···通过···分析···测量···,获···柱单···受到···荷时···特性···。本···的研····如···1）···脊柱···扫描···通过···构方···向工···,利···图像···几何···有限···和分···（M···cs···om···c ···ig···yp···es···ba···）,···兔单···12···和有···型。···通过···前期···体静···实验···固定···方式···立的···的单···限元···行了···验证···对比···静态···有限···获得···—时···与静···实验···载荷···曲线···有限···结果···结果···比较···从而···该有···型的···。（···立单···12···元模···先通···aq···行网···的敏···析并···适的···量,···拟和···不同···率和···性变···不同···松程···）对···力分···响。···建立···柱的···椎体···有限···,分···一工···同单···12···的力···的差···5）···剖3···1天···新西···兔,···12···的单···在I···ro···EA···93···地式···验机···椎体···击实···而获···椎体···状态···学损···。通···元模···析与···据处···析,···得如···点结···1）···限元···可以···同数···格对···的应···量的···果存···的影···其对···影响···显。···数量···22···有限···的计···比其···数量···析结···理的···2）···的冲···下,···析单···体位···间曲···得出···料跟···脆性···样,···垂直···用时···生4···的破···。并···的应···主要···单椎···端,···传递···骨小···向趋···。（···过对···模型···种不···料属···模拟···同程···疏松···体力···分析···骨密···力学···差,···生骨···伤.···性的···是有···析比···的一···,最···相应···来确···参数···的材···仅可···方法···而不···有限···结果···。（···过单···落锤···击实···得了···的载···间曲···且发···由多···成,···原因···由于···构复···且椎···料属···均质···异性···结构···;单···坏的···要分···阶段···个阶···关节···弓的···第二···椎体···。本···究结···了解···受到···荷时···的爆···折的···制以···椎体···性能···要的···也为···学上···损伤···、治···防护···定的···值。

骨缺···材料···需求···的生···材料···引导···（G···膜的···作为···障,···组织···处长···通过···斥促···生,···现牙···。天···织是···度矿···组织···由有···I型···非胶···）和···基磷···n-···无机···7级···序排···式相···而形···维内···原是···的基···单元···为其···机械···和生···能的···构基···此,···然骨···、结···以及···化过···材料···、结···设计···,这···制备···生人···复材···效方···电纺···维具···控的···构、···率和···面积···模拟···胞外···结构···功能···泛应···组织···仿生···获得···能高···的人···有效···本文···骨组···和骨···静电···纤维···制的···结合···组织···架的···求,···于静···酰胺···）的···工骨···料。···/P···是一···与骨···白相···成聚···在人···中具···的稳···同时···好的···、硬···纺性···HA···具有···、生···性、···晶体···似于···灰石···是骨···程的···料。···以类···结构···6/···6为···通过···丝、···性、···化以···表面···术,···于静···A6···66···人工···材料···进行···生物···研究···应用···骨修···1）···丝之···A6···溶液···Ca···制备···66···Cl···纳米···然后···和钙···浸泡···米纤···成n···涂层···表明···A6···纺纤···入C···2可···纤维···性,···提高···纤维···强度···。C···可以···HA···提供···位点···了静···维表···HA···力。···PA···Ca···支架···好的···容性···促进···胞增···的能···2）···电纺···制备···配比···胺-···聚糖···6/···支架···6与···混纺···支架···性能···1.···拟体···.5···F）···化法···纺P···CS···面制···HA···n-···粒呈···球形···分布···6/···架表···时n···涂层···增强···的力···。结···具有···基质···然结···学性···化P···CS···架无···性、···好的···容性···进M···3-···胞附···殖。···选定···/C···纳米···强相···剂浇···电纺···相结···计了···型P···CS···HA···6双···于引···骨再···种新···材料···自然···固有···结构···也实···缝集···状结···-H···A6···电纺···/C···过分···作用···键合···合,···两层···结合···PA···S@···A/···层膜···强度···模量···1.···0.···MP···.1···.0···a,···一n···/P···合支···A6···@n···/P···膜支···良好···性能···安全···物活···物相···骨传···有望···导骨···GB···

微球···比表···良好···性等···是常···注射···载体···传统···微球···是致···或者···构,···好地···胞外···纤维···增强···材料···相互···近年···研究···米线···以很···向运···,还···递生···。二···（T···）是···机材···有稳···学性···载体···面有···用前···素蛋···种常···子材···有良···物相···水溶···性及···能等···普遍···生物···域。···拟通···的水···先合···具有···构的···2纳···球,···丝素···其表···改性···丝素···Ti···米线···球,···了丝···前后···2纳···球的···容性···研究···为细···的应···研究···括以···方面···）T···纳米···备及···以钛···酯为···通过···凝胶···了T···纳米···然后···性水···Na···溶液···Ti···米颗···备T···纳米···用S···TE···RD···-I···器对···的样···表征···表明···O2···粒经···热处···变为···为1···0 ···纳米···2）···构T···纳米···的制···表征···明胶···O2···粒等···,通···法制···胶/···2纳···复合···经高···制得···2纳···微球···将T···纳米···球在···OH···水热···得T···纳米···。利···M、···、F···R等···所制···品进···。经···分析···分析···Ti···米线···现球···结构···约为···μm···由许···线组···径约···-2···m。···2纳···球主···、O···三种···成,···分为···相和···相。···Ti···米线···表面···生物···评价···O2···微球···丝素···的混···中对···表面···得丝···iO···线复···。然···iO···颗粒···Ti···米线···丝素···O2···复合···别与···9细···共培···用M···和活···胞染···细胞···分别···量和···究,···SE···观察···不同···的黏···,评···备微···物相···结果···与T···纳米···球相···iO···线微···附的···量增···经过···面改···Ti···米线···黏附···数量···多,···展状···。表···O2···微球···/T···纳米···微球···作为···体再···,且···白进···高材···物相···促进···黏附···。

自然···生物···组织···几乎···于矿···。基···（M···通常···是人···织中···石形···始部···参与···过程···由于···部C···和P···-离···升高···磷酸···沉积···s膜···并最···成为···灰石···）晶···外,···质基···物之···节的···无机···用,···入式···实现···化成···。在···下,···生矿···研究···工程···具有···构的···体的···仅可···成骨···附着···以为···化前···骨组···成提···略。···（A···具有···生物···且易···阳离···形成···,因···泛应···备骨···程支···而,···架或···目前···在临···功应···组织···其主···是宏···物的···质交···有限···过程···产生···口且···疗不···状的···。因···LG···于具···这些···潜力···广泛···综上···本研···Ca···联的···微球···机基···用D···培养···矿化···拟M···部的···境,···G微···仿生···成类···石。···本研···究了···LG···M-···微球···态、···理、···容性···性能···,本···研究···主要···下几···:（···据静···（E···术的···建了···置。···S装···用C···l2···联剂···LG···此外···改变···制备···究制···对A···球的···尺寸···。结···,A···体溶···、金···内径···速度···电极···加速···参数···的形···寸有···响。···考虑···的可···和物···速率···,本···AL···溶液···.5···%,···头内···14···,推···1.··· L···环形···径7···,加···13···V为···数,···径为···±4···藻酸···以用···实验···（2···模拟···内部···始的···本研···DM···养基···化液···外建···骨组···起始···似的···境以···生矿···交联···的C···可为···供成···。结···,在···期,···A晶···1.···9.···nm···在A···球膜···随着···P的···积,···体聚···了球···颗粒···4.···32··· n···并最···AL···的表···HA···此外···AL···表面···颗粒···较低···度,···Vs···的类···石晶···相似···）为···AL···和M···G微···胞相···成骨···本研···CC···法、···e-···d染···和A···性检···了不···对成···的生···殖及···影响···显示···AL···表现···的细···性,···涂层···有利···细胞···移并···M-···微球···AL···检测···示,···LG···明显···骨细···LP···**···0.···）,···M-···微球···进成···的能··

骨骼···同时···相和···孔隙···当宏···骼受···载荷···,微···骨陷···小管···la···ar···na···ul···sy···m,···）内···胞周···的液···受到···电场···作用···此引···体流···激与···触的···及其···初级···细胞···。本···研究···通道···窝-···系统···体环···细胞···的各···信号···情况···因素···Co···l多···耦合···软件···利用···分析···探讨···激下···黏弹···力学···用,···利于···物力···指导···松、···炎等···病的···及骨···的骨···。细···复杂···环境···附着···表面···纤毛···是重···学信···器,···胞的···发育···和增···理活···相关···研究···其初···在微···境下···导行···二章···力-···驱动···形微···道和···孔粘···性的···胞有···型系···察了···细胞···胞核···层流···力、···孔隙···孔隙···力学···应,···究了···毛作···独特···感受···物力···。为···骨陷···小管···流体···的细···信号···第三···了骨···骨小···内包···质、···、细···、初···和胶···的细···,考···-电···陷窝···管系···体流···多孔···细胞···和液···学行···二章···明:···振荡···的力···表现···加力···动载···的震···。渗···细胞···性力···的主···因素···纤毛···主要···感受···胞可···纤毛···直径···力学···感性···影响···。随···纤毛···增大···毛挠···减小···敏感···。模···立为···研究···剪切···的细···、分···观机···基础···也为···胞微···（纤···白链···学性···了理···支持···章的···明:···触和···毛都···的力···元件···突触···方向···也会···胞体···信号···突触···的长···生长···的力···要强···突触···的短···生长···,骨···细胞···多,···知到···信号···。胶···的存···了细···的力···能力···原小···性模···这种···好。···毛的···知能···出位···性的···并没···出长···的依···模型···有利···细胞···对细···的影··

二氧···Ti···纳米···种典···米无···,具···的比···、优···催化···较好···相容···经广···工业···医学···。基···水热···作简···物结···调控···已经···前最···的T···纳米···方法···的基···主要···TO···钛片···所制···iO···线与···料之···面作···往较···致T···纳米···从基···表面···形态···难以···本研···Ti···米颗···基质···采用···热反···Ti···米颗···面原···Ti···米线···过改···温度···对其···形态···控;···采用···养方···探究···O2···膜的···容性···文主···以下···分:···Ti···米线···及表···以T···纳米···基质···热合···O2···。以···丙酯···,通···-凝···备T···纳米···然后···备的···2纳···为原···用碱···法制···O2···。利···M、···、T···XR···T-···对T···纳米···Ti···米线···征。···明,···2纳···呈现···颗粒···寸约···-2···nm···性水···处理···iO···颗粒···形）···化为···为1··· n···iO···线（···相）···）T···纳米···合成···接下···iO···颗粒···质材···合成···2纳···。以···2纳···为原···用圆···锈钢···压片···置制···O2···粒片···以T···纳米···为基···,采···水热···iO···颗粒···原位···iO···线膜···SE···DS···D等···的T···纳米···和T···纳米···行表···果表···热反···Ti···米颗···面形···粒状···纤维···表面···iO···颗粒···化为···2纳···纳米···径随···反应···改变···变化···热反···从1···提高···0℃···直径··· n···至1···同时···热过···行,···2纳···的晶···也发···变,···矿相···化为···（3···O2···膜的···容性···后以···细胞···9为···胞评···iO···线膜···相容···Ti···米线···92···共培···用M···和活···胞染···别定···性评···iO···线膜···胞活···响;···用S···察细···iO···线膜···生长···结果···Ti···米线···细胞···与增···有优···物相···其生···性与···直径···较小···纳米···促进···黏附···。

骨关···一种···的复···,严···人类···尽管···生和···发病···不完···,但···损已···是其···的一···环节···表明···缺损···流动···改变···产生···后果···反馈···的发···中,···致软···行性···而且···损软···愈能···有限···关节···换和···织工···节软···领域···良好···前景···论是···节软···是软···工程···必须···定的···求和···求,···软骨···功能···,关···材料···表征···软骨···软骨···预措···要前···今,···量的···关节···度相···学特···了研···这些···是基···软骨···征,···区域···可能···响。···物阻···已被···用于···临床···它可···到组···的轻···,但···没有···软骨···关的···特性···究。···骨深···的力···和电···还有···步研···文的···作及···下:···本文···立了···化的···性关···模型···了理···骨损···中孔···压力···的解···通过···LA···赋值···与有···果对···果显···解析···限元···有良···致性···步地···真实···关节···多孔···型,···不同···表面···组织···力和···影响···一步···骨退···制。···由于···程中···骨的···性明···而弹···明显···本文···了渗···和弹···的影···果显···常软···,缺···的间···压力···均减···随着···径或···增加···趋势···重。···骨退···的发···体流···造成···营养···失,···是液···参与···伤机···2）···猪关···的上···下三···分别···电阻···,压···试验···透率···得到···个区···电阻···位角···模量···时间···松弛···及渗···数据···讨猪···骨的···学特···学特···服务···骨关···病的···诊断···修复···研究···。研···表明···软骨···学性···阻抗···在显···,其···率,···量,···间和···弛速···软骨···表层···逐渐···而渗···软骨···表层···逐渐···本文···论数···和有···方法···软骨···间隙···动进···究,···们还···节软···学特···学特···了探···在为···关节···的治···断及···复材···究和···供数···。

目前···的骨···料多···金、···聚合···这些···生物···不可···往往···次手···且因···的硬···易造···屏蔽···于骨···位的···因此···可降···植入···广泛···如水···其具···水量···结构···作为···殖、···分化···。特···物性···天然···胶,···学改···成甲···酰胺···Me···la···la···e ···at···Ge···A）···有光···、易···特别···一些···的骨···由于···的主···盐成···羟基···（H···ox···at···,H···骨修···就是···不断···所以···骨植···应该···诱导···作用···一种···物可···、骨···、良···相容···入材···要。···加支···诱导···过仿···在水···面矿···一层···在增···导力···,也···水凝···械性···后通···体内···骨组···我修···导骨···围自···细胞···多孔···,通···增殖···成新···,同···支架···降解···新生···完全···植入···骨缺···愈合···所述···究采···交联···l ···Ca···联的···钠（···iu···lg···te···g）···机模···拟生···的矿···境,···条件···7 ···利用···液交···,在···凝胶···生矿···HA···然后···水凝···观结···胀率···率、···能等···征,···化形···涂层···、稳···最后···外细···验证···凝胶···相容···诱导···此,···的研···主要···下几···:（···用甲···酸酐···）对···性,···光固···el···,利···l ···Al···复合···,探···Al···对水···溶胀···隙率···等的···实验···明,···的加···复合···的溶···所降···el···/1···g水···溶胀···81···1±···52···因为···的加···了聚···络的···度;···el···中的···2和···的─···H之···强的···互作···复合···具有···均匀···多孔···可以···环境···物质···和代···的排···2）···生物···矿化···,以···作为···板,··· o···下进···矿化···凝胶···化钙···Ca···2）···,利···2+···lg···为H···的形···成核···然后···在磷···钾溶···2H···）中···钙盐···逐渐···A涂···且G···MA···的精···甘氨···冬氨···GD···也有···A的···随着···间的···水凝···的矿···积越···验结···,A···加入···HA···形成···形成···涂层···较好···后水···多孔···发生···变。···为验···水凝···物相···骨诱···将小···成骨···体细···C3···E1···与未···凝胶···水凝···养,···CK···、活···法、···酸酶···P）···检测···细胞···、粘···力、···影响···其生···性和···性。···果表···化前···胶对···T3···细胞···和活···显影···胞可···增殖···粘附···,细···生长···伪足···el···/A···HA···凝胶···P活···高与···,其···利于···成骨···可以···骨组···成。