The Outer · · · Cholerae

项目来源

美国卫生和人类服务部基金(HHS)

项目主持人

HALL, ROBERT ·

项目受资助机构

UNIVERSITY OF ·

项目编号

5R01AI076322-10

立项年度

2017

立项时间

未公开

研究期限

未知 / 未知

项目级别

国家级

受资助金额

376167.00美元

学科

Biodefense; Biotechnology; · · · Infectious Diseases; · ·

学科代码

未公开

基金类别

Non-SBIR/STTR RPGs

关键词

未公开

参与者

TRENT, MICHAEL ·

参与机构

NATIONAL INSTITUTE · · · INFECTIOUS DISEASES

项目标书摘要:DESCRIPTION (provided · · · bacterial cell · · · remarkable and · · · guards bacteria · · · environment. A · · · Gram-negative bacteria · · · of an · · · encapsulates the · · · these organisms. · · · membrane is · · · the outer · · · unique, asymmetric · · · confined to · · · and lipid · · · saccharolipid, localized · · · leaflet. Lipid · · · lipid moiety · · · and anchors · · · bacterial surface. · · · various mechanisms · · · their unpredictable · · · surroundings, including · · · their membrane · · · modifications provide · · · of the · · · system and · · · of the · · · lipid A · · · is toxic · · · potent stimulator · · · immune system · · · by TLR4- · · · of Gram-negative · · · lipid A · · · host detection. · · · of lipid · · · can directly · · · to innate · · · as host · · · overall objective · · · is to · · · mechanisms by · · · the causative · · · disease cholera, · · · architecture and · · · remodeling plays · · · Specific Aims · · · application are: · · · genetic analysis · · · of V. · · · Biochemical and · · · phosphoethanolamine modification · · · LPS; (3) · · · required for · · · V. cholerae; · · · of V. · · · on the · · · response. The · · · Aims will · · · our understanding · · · remodeling/modification machinery · · · from this · · · not only · · · of the · · · new avenues · · · and the · · · engineered LPS · · · serve as · · · LPS antagonists.

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  • 1.Th···ow···of···ym···ry···rc···ec···e ··· A···mb···of···e ···m-···at··· O···r ···br··· L···d ···ay··

    • 关键词:
    • ZINC-DEPENDENT DEACETYLASE; CELL-ENVELOPE BIOGENESIS; TIGHT-BINDING INHIBITOR; ABC TRANSPORTER MSBA; ESCHERICHIA-COLI; NEISSERIA-MENINGITIDIS; LIPOPOLYSACCHARIDE TRANSPORT; PHOSPHOGLYCEROL TRANSFERASE; CARDIOLIPIN BIOSYNTHESIS; PSEUDOMONAS-AERUGINOSA
    • He···rs··· J···my···;Z···er···, ···wn···;C···ts···le···de···.;···l,···se···M.···hn···Li···G.···rr···, ···me···.;···nt···. ···ph··
    • 《AN···L ···IE···F ···RO···LO··· V···70》
    • 2016年
    • 会议

    De···mi···g ··· c···ic···co···si···n ···bi···gi··· m···ri··· i···ar···un···o ··· s···y ···na···al···en···na···er···we···sc···e ··· c···os···on··· m···l ···m-···at··· o···r ···br···s,···cu···g ···th···re···in··· a···mb··· a···sy···tr···l ···ay···of···pi···ol···le···We···o ···e ···ov···ie···f ···id···os···he··· p···wa···an···ol···la···ec···is···th···or···iz···hi···at···al···to···e ···er···mb···e ···ay··· A···mp···is··· p···ed··· t···po···ti···of···es···at···ys··· t···et···or···ti···ti···ev···pm···. ···di···ss···vi···on···n ···po···io···th···gh···ct···al···ll···rf··· r···de···g,···d ···er···iv···od···ti···to···e ···mm···ic···pi···il···r.···te···em···ne···pi···lt···ti··· o···ur···t ···ro···lo···al···te···t,···ch··· l···d ···uc···es···un···n ···me···l ···te···, ··· e···as···d.···di···na···, ···er···mb···e ···po···ts···ul···ot···ia··· b···ng···er···to···ve··· v···in···la···rm···Ob···va···ns···la··· t···om···it··· a···as···bl···f ···m-···at··· o···r ···br···s ···l ···ti··· t···en···te···ve···is···er···, ···ad···bi···ch···og···, ··· r···al···of···d ···te···s ···co···l ···ur···es···ch·

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