The Outer · · · Cholerae

项目来源

美国卫生和人类服务部基金(HHS)

项目主持人

HALL, ROBERT ·

项目受资助机构

UNIVERSITY OF ·

立项年度

2017

立项时间

未公开

项目编号

5R01AI076322-10

项目级别

国家级

研究期限

未知 / 未知

受资助金额

376167.00美元

学科

Biodefense; Biotechnology; · · · Infectious Diseases; · ·

学科代码

未公开

基金类别

Non-SBIR/STTR RPGs

关键词

未公开

参与者

TRENT, MICHAEL ·

参与机构

NATIONAL INSTITUTE · · · INFECTIOUS DISEASES

项目标书摘要:DESCRIPTION (provided · · · bacterial cell · · · remarkable and · · · guards bacteria · · · environment. A · · · Gram-negative bacteria · · · of an · · · encapsulates the · · · these organisms. · · · membrane is · · · the outer · · · unique, asymmetric · · · confined to · · · and lipid · · · saccharolipid, localized · · · leaflet. Lipid · · · lipid moiety · · · and anchors · · · bacterial surface. · · · various mechanisms · · · their unpredictable · · · surroundings, including · · · their membrane · · · modifications provide · · · of the · · · system and · · · of the · · · lipid A · · · is toxic · · · potent stimulator · · · immune system · · · by TLR4- · · · of Gram-negative · · · lipid A · · · host detection. · · · of lipid · · · can directly · · · to innate · · · as host · · · overall objective · · · is to · · · mechanisms by · · · the causative · · · disease cholera, · · · architecture and · · · remodeling plays · · · Specific Aims · · · application are: · · · genetic analysis · · · of V. · · · Biochemical and · · · phosphoethanolamine modification · · · LPS; (3) · · · required for · · · V. cholerae; · · · of V. · · · on the · · · response. The · · · Aims will · · · our understanding · · · remodeling/modification machinery · · · from this · · · not only · · · of the · · · new avenues · · · and the · · · engineered LPS · · · serve as · · · LPS antagonists.

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  • 1.A ···le···ll···re···Id···if··· S···l ···ac···es···at···ne···ze···th···ly···in···d ···ib···An···ic···ia···ct···ti···ag···st···lt···ug···si···nt···ct···a

    • Zi···rm···Sh··· M···fo···in···ud···-A···J;···re···Ca···n ···cl···,A···da···Tr···,M···ep···;
    • 《An···ic··· A···ts···em···er》
    • 2020年
    • 64卷
    • 3期
    • 期刊
  • 3.To···ow···ha···te···at··· o···ip···ig···cc···id···fr···An···io···-R···st··· B···er··

    • 关键词:
    • PHOTODISSOCIATION MASS-SPECTROMETRY; ACINETOBACTER-BAUMANNII; STRUCTURALELUCIDATION; CORE OLIGOSACCHARIDE; ESCHERICHIA-COLI; MALDI-TOF;LIPOPOLYSACCHARIDE; COMPLEX; PHOSPHORYLATION; NEISSERIA
    • Kl···, ···ti···.;···er···Ma···ew···;T···t,··· S···he···ro···lt···en···er···
    • 《AN···TI··· C···IS···》
    • 2019年
    • 91卷
    • 15期
    • 期刊

    Mo···ic···on··· s···ct···s ···li···li···ac···ri··· (···) ···re···ts···e ···va···t ···ha···m ···wh··· G···ne···iv···ac···ia···n ···om···es···an···o ··· a···bi···cs···wi···to···e ···ni···an···om···xi···of···S,···e ···uc···al···ar···er···ti···of···es···mp···at··· l···ds···s ···ge···fo···ed··· e···id···on··· t···li··· A···bs···ct···s.···al···s ···in···t ··· e···le···et···io···f ···e ···go···ch···de···di···at···s ··· g···s ···ig···in···th···et···ge···ty···at···su··· f··· c···in···on···f ···id···an···li···ac···ri···su···ru···re···To···ow···na···is··· i···ct···S ···o ···vi··· t···op···tu···y ···de···mi···un···wn···ig···cc···id···tr···ur··· w···h ···pa···cu···ly···va···ge··· i···he···nt··· o···ly···on···at···ac···e ···el···en···Ad···ce···n ···s ···ct···et···te···ol···es···nc···in···he···ve···me···of···n ···ab···ti···an···lt···at··· i···ac···at··· t···ni···s,···ve···de···p-···n ···ly··· a···nd···en···le···ol···r ···uc···al···ar···er···ti···of···mp··· b···ol···le···He···we···mb··· o···ne···ro···og···hi···ep···ti··· w··· M···ut···zi···ul···vi···t ···to···so···ti···(U···) ··· h···er···er···co···si···l ···so···ti···(H···. ··· g···ra··· p···id···in···ma···n ···ut···e ···se··· o···ab··· m···fi···io···vi···eu···l ···s ···gm···s ···ad···io···o ··· s···ha···e ···ka···ar···ge···t,···er··· U··· g···s ···e ···ai··· i···gh···bo···sa···ar··· b···ch··· a···th···os···on···f ···st···hi···tr···mo···ic···on···Th···in···ra··· a···oa···wa···se···o ···ra···ri···LO···ro···ci···ob···er···um···ii···05···d ···5.···ta···, ··· a···ys···of··· b···an··· 1···, ···an···io···-r···st··· s···in···on···me···ho···oe···no···in···nd···xo···in···od···ca···n ···th···ip···A ···st···tu···an···ur···r ···bl···de···at··· o··· c··· o···os···ha···e ···uc···e.

    ...
  • 7.Di···ve···of···xt···ne···io···nt···cr···al···hr···h ···te···l ···f-···ee···g ···Su···ce···sp···ed···pt··· L···ar···

    • 关键词:
    • ESCHERICHIA-COLI; OUTER-MEMBRANE; PSEUDOMONAS-AERUGINOSA; DE-NOVO;DATABASE; SUSCEPTIBILITY; ACTIVATION; SEQUENCES; COMPONENT; APOPTOSIS
    • Tu···r,···hl···T.···on···, ···n ···Du···s,···ry···;K···f,···eg··· A···un···gh··· A···ey···;W···e,···au···.;···nt···. ···ph···Da···s,···ya···.
    • 《CE··》
    • 2018年
    • 172卷
    • 3期
    • 期刊

    Pe···de···av···re···po···ti···to···mb···an···io··· r···st···e.···il···an···la···rm···an···re···pe···de···or···ei···bi···y ···bi···to···rg···ce···, ···re···e ···tu···y ···pl···or···th···di···tl···ss··· t···fu···io···it···f ···ti···. ···s ···it···on··· e···er···ed···en···en···yi···an···ic···ia···ep···es···ca··· t···ph···ty··· d···h,···le··· a···ns···ts··· a···ha···au··· a···ie···fi···ot···ne···th···co···ne···es···ch··· a···w ···ur···y ···ur···g ···ss···of···ti···ro···l ···ti···. ···ha···us···th···se···ng···ss···nc···o ···el···Su···ce···ca···ed···ti···ro···l ···pl···(S···),···pl···or···ha···ll··· s···en··· o···nl···te···um···s ···pe···de···f ··· l···th···om···it···, ··· s···ct··· i··· s···le···be···r ···im···ob··· a···vi··· U···g ···Y,··· s···en···si···ar··· 8···00···an··· p···id···eq···ce···or···ti···ro···l ···ct··· a···id···if··· t···sa··· o···ct··· s···en···, ···ma···al···in···as··· t···nu···r ···kn··· a···mi···bi···se···nc··· S··· h··· p···en···it···if···en···ot···ia···ec···is···of···pt··· a···on···d ···es···o ···as··· a···mi···bi···ph···co···mi··· s···e ···on···ha···at··· h···ev···ed·

    ...
  • 8.Ca···lo···te···ej··· t···sc···ti···l ··· g···ti···da···ti···du···g ···an···fe···on

    • 关键词:
    • PHASE VARIATION; IRON ACQUISITION; IN-VIVO; COLONIZATION; VIRULENCE;EVOLUTION; SYSTEM; IDENTIFICATION; TRANSMISSION; FLAGELLIN
    • Cr···s,···ex···er···;P···, ···de··· M···wi··· C···yl···;K···iw···Ja···le···;R···er···oa··· E···ar··· C···to···ac···Da···;T···at···aw··· R···or···, ···d ···Gu···rr··· R···ro···;D···ar···, ···ba···Br···ke···Je···ca···ir···Re··· M···au···Al···nd···C.···ep···ay···Al···a,···hl···Tr···le···av···R.···dd··· M···. ···Ra···ri···an···mr···a;···oy···nd··· J···av···, ···an···;G···ry···at···ia···en···M.···ep···
    • 《NA···E ···RO···LO··》
    • 2018年
    • 3卷
    • 4期
    • 期刊

    Ca···lo···te···ej··· i···ct···s ··· a···ad··· c···e ···ba···ri···fo···bo··· d···rh···l ···ne···wo···wi··· a···Ca···lo···te···nf···io···in···il···n ··· a···ci···d ···h ···nt···gr···h ··· t···ef··· l···-t··· d···ci···in···ad···ho··· D···it···hi···lo··· i···ct··· h···th···d ···an···pi···, ··· z···ot···C.···ju···re···nd···o ··· h···n ···t ···ai···un···ar···nl··· o···r ···es···al···th···ns···. ···un···oe···ot···rb··· p···og···de···in···ox··· t··· e···ic···y ···tr···te··· d···as···n ···an···Th···ma··· u···rs···di···Ca···lo···te···at···en···s ···ll···in···nd···pp···s ···ro···ex···na···n ···ba···ri···fa···rs···at···nt···ut···o ···je···i ···ec···n.···re···e ··· a···nt···le···um···in···ti···mo··· t···ha···te···e ···je···i ···ns···pt···al···d ···et···ad···at···s ···vi··· a···g ···h ···on···ma···ri···e ···ec···n ···el··· v···da···ou···pp···ch···e ···nd···at···ri···on··· 1···en···is···so···te···it···it··· a···e ···pe···st··· h···n ···ec···ns···d ···lu··· p···uc···in···ve···n ···t ···l ···as···, ···e ···si···an···la···la···di···at···, ···s ···it···al···te···al···er···ut···ta···ts···n ···ti···ar··· f···ti···l ···si···of···e ···l ···as··· p···ei··· (···A)···ne···od··· i···tr···ly···so···te···it···er···te···y ···ec···g ···te··· a···we···en···ie···ts···oc···ic···ro···in···ag···a ···if···ti··· T···e ···a ···ra···ri···th···da···ve··· j···ni···sp···e ···pr···te···fe···on···nd···gg··· t···ap···es··· s···ld···ns···r ··· i···in··· d···er···es···tw··· a···e ··· p···is···tl···nf···in···ac···ia···n ···it···, ··· s···en···g ···ea··· c···er··· r···on··· d···ng···tu··· h··· c···en···is···nd···ma···nf···io··· T···ty···ne···ne···er···if···en···ll···eg···te···n ···o ···os···os··· l···st···s ··· C···ej··· s···in···Th···co···rv···in···vo···sp···e ···hl···ts···po···nt··· j···ni···rv···l ···ha···ms···ch··· i··· a···is···on···d ···si···of···e ···t ···os···im···e ···po···. ···se···va···s ···hl···t ···ho··· a···ta···it···cr··· h··· s···ie···nd···mo···ra···th···ti···y ···mu···di···pl···ry···ll···ra···ns··· f···re···in···l ···al···o ···dy···th···ns··· v···.

    ...
  • 9.En···ot···ge··· E···ol···ir···nc···en···eg···ti···in···ma···nf···io··

    • 关键词:
    • ETEC; enterotoxigenic E. coli; FNR; toxin; cfa;HEAT-LABILE ENTEROTOXIN; ESCHERICHIA-COLI; CFA/I FIMBRIAE; MODULATION;BIOFILMS; STRAINS; EXPRESSION; CYSTITIS; TOXIN
    • Cr···s,···ex···er···;G···an···i,···mo···M.···bi···Er··· J···ol···Fr···ri···.;···ie···z,···mi···L.···la··· K···ar···;P···er···ha···.;···dl···Ma···S.···Ne···ng···ar···a;···ba···, ···si···Ma···l,···lt··· J···Al···a,···hl···N.···ak···or··· S···ra···ou··· M···ae···.;···ar···, ···ph···J.···vi··· B···n ···Tr···, ···St···en
    • 《PR···ED···S ···TH···AT···AL···AD··· O···CI···ES··· T···UN···D ···TE···FA···IC·》
    • 2018年
    • 115卷
    • 38期
    • 期刊

    En···ot···ge··· E···er···ia···li···TE···is···gl···l ···rr···l ···ho··· t··· u···iz···ad···in···nd···cr···d ···er···xi···to···us···is···e ···ma···li···ho···. ···ad···of···se···h ···vi···en···fa···r ···ul···on··· E··· h···re···le··· v···et···f ···ir···en··· f···or···ha···nf···nc···en···xp···si··· i···ud··· b···, ··· b···rb···te···sm···ri··· a···gl···se···ow···r,···he···al···rk···f ··· i···st···l ···ct···uc···s ··· o···en···ai···il···, ···e ··· b··· e···in··· F···he···de···mi···g ··· E··· i···gr···s ···se···gn··· i···he···mp··· h··· e···ro···nt··· c···le···ng···o ···re···th··· w···ha···te···ed···EC···re···ns···o ··· h···n ···t ···ng···mp··· f··· a···nt···le···um···in···ti···mo···. ···fo··· E··· s···es···vi···me···l ···ge···o ···ba··· i···ue··· v···le··· f···or···pr···io···ia···e ···ge···en···iv···ra···ri···on···re···at···fu···at···nd···tr··· r···ct··· (···) ···ul···r.··· v···o ···er···c ···wt···ep···at···th···n ···o ···ul···e ···to···xp···si···pr···le···nd···le···n ···fn···n ···C ···ai···10··· r···lt···n ···ig···ic··· i···ea···in···pr···io···f ··· c···si··· v···le··· f···or···in···di···th···ol···za···n ···to···nt···n ···CF···) ···es···op···n ··· b··· h···-s···le···d ···t-···il···nt···to···s.···es···at···ep··· a···de···f ···C ···ec···n ···re···R ···iv··· c···gl···ll···nf···nc···ir···nc···en···xp···si··· a···th···fo···pr···mi···to···e ···ge···ed···ne···rd···ng···te···na···pi···li···ce··· l···ly···fl···ce···TE···ir···nc···en···xp···si···in···vo···ut···e ···th···os···ET···bi···lm···re···so···te···it···ea···al···EC···id···cs···nd··· f··· F···is···re···at···of···of··· p···uc···n.···ge···r ···se···ta···gg··· F···de···de···ox···n ···si···in···EC···s ···li···io···fo···um···in···ti···in···e ··· o···id···f ··· h···.

    ...
  • 10.Ex···di···th···ar···gm···r ··· o···r ···br···:A···et···ct···ba···nn···in···e ···en···of···do···in

    • 关键词:
    • PENICILLIN-BINDING PROTEINS; ESCHERICHIA-COLI; POLYMYXIN RESISTANCE; PHOSPHOETHANOLAMINE MODIFICATION; MOLECULAR-BASIS; PMRCAB OPERON; LIPOPOLYSACCHARIDE; DEFICIENT; TRANSPORT; SALMONELLA
    • Po···s,···tt··· J···ph···en···M.···ep···
    • 《MO···UL···MI···BI···GY》
    • 2018年
    • 107卷
    • 1期
    • 期刊

    As···et···in···e ···er···mb···e ··· l··· d···ne···he···ll···ve···e ···Gr···ne···iv···ac···ia···hi···sy···tr···wi···li···ol···cc···id···LP···or···po···go···ch···de···OS···xc···iv··· i···he···te···ea···t ···th···em···ne···st···is··· a···mp···ea··· b···ie···ha···ro···ts···e ···l ···m ···um··· o···tr···or···n ··· e···ro···nt···or···on···ve···he···st···ye··· h···sh··· t··· A···et···ct···ba···nn···ha···he···ma···bl···ap···li···to···rv··· w··· i···ti···ed···od···io···f ···id···bi···nt···is···d ··· a···nc···f ··· i···ts···te···em···ne···he···pl···ti··· o···OS···fi···nt··· b···an··· a···fa···ea···ng···fr···im···ts··· c··· e···lo···bi···ne··· a···ma···en···e,···ct···al···ys···og···an···io··· r···st···e ··· v···le···. ···s ···ie···xa···es···ce···wo···th···ha···on···bu··· t···ur···de···an···g ···LO···ef···en···an···om···es··· t···tu···s ···e ···Ne···er···me···gi···is···d ···ax···a ···ar···li···th···wo···he···rg···sm···it···hi···ap···li···

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