Elucidating the mechanisms of[4Fe-4S]cluster insertions into the cytosolic iron-sulfur protein assembly component Nar1

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德(略)基(略)F(略)

项目主持人

J(略)p(略)a(略) (略)y(略)

项目受资助机构

P(略)i(略)-(略)v(略)i(略) (略)b(略),(略)h(略)e(略) (略)i(略),(略)t(略)t(略)r(略)t(略)o(略)i(略)

项目编号

4(略)4(略)5

立项年度

2(略)

立项时间

未(略)

研究期限

未(略) (略)

项目级别

国(略)

受资助金额

0(略)欧(略)

学科

B(略)h(略)s(略);(略)l(略)o(略)y(略)r(略)u(略) (略)l(略)

学科代码

未(略)

基金类别

P(略)r(略) (略)g(略)m(略)

关键词

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参与者

Dr. J(略)p(略)a(略) (略)y(略), Ph.D.

参与机构

未(略)

项目标书摘要:De(略)actor tra(略)d inserti(略) are an i(略)pect in a(略)of biosyn(略)metabolic(略)The cell (略) mechanis(略)ifically (略) which co(略) inserted(略) protein,(略)ucturally(略)oteins wi(略)t cofacto(略)es.A majo(略)al or bio(略)ofactor t(略)ctions ar(略)by protei(略)ons,yet m(略)detail re(略)ar for ma(略)roteins i(略)pass cofa(略)one prote(略)ext,espec(略)tes burie(略)oteins.Th(略)to one of(略)biquitous(略)ofactors (略)cteria,ar(略)ukaryotes(略)n sulfur((略)rs.In the(略)ryotic or(略)haromyces(略),18 mitoc(略)/S cluste(略)bly prote(略)cytosolic(略)in assemb(略)onents cr(略)ensive ce(略)ein netwo(略)nthesizes(略)nd insert(略)ters into(略)proteins.(略)ing aspec(略)A machine(略)yotes is (略)f the tra(略)ctors the(略)d more th(略) cluster (略)ins poorl(略)d how the(略)ents them(略)matured.F(略)Nar1 is p(略)ause it h(略)posed to (略)]cluster (略) mediator(略) pathway (略)e[4Fe-4S](略) at the s(略)target ap(略)at requir(略),non-tran(略)e-4S]clus(略)more,Nar1(略)ous to ba(略) algal[Fe(略)nases,but(略)ve the ch(略)c hydroge(略)on.Why a (略)-like pro(略)olved as (略)l eukaryo(略)uster tra(略)otein rem(略) the most(略)g questio(略)ss in the(略)er biogen(略)The aim o(略)osal is t(略)bination (略)in vitro,(略)ical stud(略)ss mechan(略)-4S]clust(略)ns into N(略)use this (略) to deter(略)ysiologic(略) of Nar1 (略)pathway.S(略) will be (略)ractable (略) study th(略)of Nar1 a(略)rtance of(略)nding pro(略)r1 matura(略)s into Na(略)on will g(略)titution (略)nvolving (略)r transfe(略)om Nar1,q(略)ia isotop(略)ched Fe/S(略)iophysica(略)ization o(略)r1 via pr(略)in intera(略)s,spectro(略) cluster (略)d X-ray c(略)phic stru(略)mination (略)e pursued(略)rough ess(略)aboration(略)P.Assigni(略)cular fun(略)r1 will a(略)understan(略) multiple(略)Fe/S clus(略) transfer(略)rted into(略)s.Subsequ(略)will also(略)r underst(略)ow disrup(略)/S cofact(略)ing lead (略)tein asse(略)es.

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