DSA融合引导支架实时精确定位

项目来源

国家重点研发计划(NKRD)

项目主持人

舒华忠

项目受资助机构

东南大学

立项年度

2017

立项时间

未公开

项目编号

2017YFC0107903

研究期限

未知 / 未知

项目级别

国家级

受资助金额

54.00万元

学科

数字诊疗装备研发

学科代码

未公开

基金类别

未公开

主动脉夹层 ; 卷积神经网络 ; 多平面重建 ; DSA融合引导支架 ; 医学影像配准 ; 成像角度优化 ; Aortic dissection ; Convolutional neural network ; Multi-plane reconstruction ; DSA fusion guidance stent ; Medical image registration ; Optimization of imaging angle

参与者

杨冠羽;李松毅;杨淳沨

参与机构

东南大学计算机科学与工程学院

项目标书摘要:主动脉夹层是一类高危的主动脉血管疾病,致死率很高。胸主动脉腔内修复术(TEVAR)因其微创伤和良好的真腔重塑效果而成为B型主动脉夹层治疗的首选方法和研究热点。主动脉夹层术前诊断规划及术后治疗需要客观量化结构参数、精准定位撕裂内膜和撕裂口位置等过程。CT 图像主动脉夹层的分割对于术前诊断、手术规划以及术后修复等具有重要的指导意义。病变紧邻主动脉弓部位三根重要分支动脉,覆膜容易堵住这些分支动脉而引发严重的并发症,为此在TEVAR手术中DSA成像角度的选取对于放置支架位置有着至关重要的影响。本文解决的关键技术有:1)提出一种基于多平面重建的3D MPRNet卷积神经网络架构,实现主动脉及撕裂内膜的精准及连续分割。2)建立线性组合相关性测度,通过共轭方向加速优化算法,实现CTA与DSA数据的精确配准。3)研究手术操作过程中影像漂移现象以及动态实时匹配的难题,构建医生、术前血管造影数据投影相对于术中DSA的位置和方向角,以及成像系统的内部参数,实现C型臂最佳成像角度优化;研究DSA与CTA影像的投影关系,并获得分支动脉的开口与支架的真实三维坐标,实现支架远末端在三维模型中的定位。4)通过流向跟踪法选取主动脉弓平面并计算其投影缩短率,构建投影平面正则化能量函数,优化最小缩短率、最小遮盖率和最大邻近间距,获取主动脉弓平面垂直成像角度。

Application Abstract: Aortic dissection is a high-risk aortic disease with high mortality.Thoracic endovascular aortic repair(TEVAR)has become the first choice and research focus for the treatment of type B aortic dissection due to its microtrauma and good remodeling effect.Preoperative diagnostic planning and postoperative treatment of aortic dissection require objective quantification of structural parameters,accurate positioning of the tearing intima and the location of the tear.Segmentation of aortic dissection in CT images is of great significance for preoperative diagnosis,surgical planning and postoperative repair.The lesion is adjacent to the three important branches of the aortic arch,and the coating is likely to block these branches and cause serious complications.Therefore,the selection of DSA imaging Angle in TEVAR surgery has a crucial impact on the placement of stents.Key technologies addressed in this paper include:1)A 3D MPRNet convolutional neural network architecture based on multi-plane reconstruction was proposed to achieve accurate and continuous segmentation of aorta and torn intima.2)The correlation measure of linear combination is established,and the precise registration of CTA and DSA data is realized through the accelerated optimization algorithm of conjugate direction.3)The problem of image drift and dynamic real-time matching during surgical operation was studied,and the position and direction Angle of the projection of the doctor and preoperative angiography data relative to intraoperative DSA as well as the internal parameters of the imaging system were constructed to optimize the optimal imaging Angle of c-arm.The projection relationship between DSA and CTA images was studied,and the real 3d coordinates of branch artery openings and stents were obtained to realize the positioning of the distal end of stents in the 3d model.4)The problem of image drift and dynamic real-time matching during surgical operation was studied,and the position and direction Angle of the projection of the doctor and preoperative angiography data relative to intraoperative DSA as well as the internal parameters of the imaging system were constructed to optimize the optimal imaging Angle of c-arm.The projection relationship between DSA and CTA images was studied,and the real 3d coordinates of branch artery openings and stents were obtained to realize the positioning of the distal end of stents in the 3d model.

项目受资助省

江苏省

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  • 1.Anisotropic tubular minimal path model with fast marching front freezing scheme

    • 关键词:
    • Trees (mathematics);Freezing;Anisotropy;Geodesy;Geometry;Fast marching methods;Geodesic distances;Quantitative experiments;Retinal vessels;Riemannian metrics;Riemannian tensors;Shortcut problem;Tree structures
    • Liu, Li;Chen, Da;Cohen, Laurent D.;Wu, Jiasong;Paques, Michel;Shu, Huazhong
    • 《Pattern Recognition》
    • 2020年
    • 104卷
    • 期刊

    In this work, we introduce an anisotropic minimal path model based on a new Riemannian tensor integrating the crossing-adaptive anisotropic radius-lifted tensor field and the front freezing indicator by appearance and path features. The non-local path feature only can be obtained during the geodesic distance computation process by the fast marching method. The predefined criterion derived from path feature is able to steer the front evolution by freezing the point causing high bending of the geodesic to solve the shortcut problem. We performed qualitative and quantitative experiments on synthetic and real images (including retinal vessels, rivers and roads) and compare with the minimal path models with classical anisotropic Riemannian metric and dynamic isotropic metric, which demonstrated the proposed method can detect desired targets from complex tubular tree structures. © 2020

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  • 2.Deep octonion networks

    • 关键词:
    • Convolutional neural network; Complex; Quaternion; Octonion; Imageclassification;GLOBAL EXPONENTIAL STABILITY; VALUED NEURAL-NETWORKS; ALGORITHM
    • Wu, Jiasong;Xu, Ling;Wu, Fuzhi;Kong, Youyong;Senhadji, Lotfi;Shu, Huazhong
    • 《NEUROCOMPUTING》
    • 2020年
    • 397卷
    • 期刊

    Deep learning is a hot research topic in the field of machine learning methods and applications. Real-value neural networks (Real NNs), especially deep real networks (DRNs), have been widely used in many research fields. In recent years, the deep complex networks (DCNs) and the deep quaternion networks (DQNs) have attracted more and more attentions. The octonion algebra, which is an extension of complex algebra and quaternion algebra, can provide more efficient and compact expressions. This paper constructs a general framework of deep octonion networks (DONs) and provides the main building blocks of DONs such as octonion convolution, octonion batch normalization and octonion weight initialization; DONs are then used in image classification tasks for CIFAR-10 and CIFAR-100 data sets. Compared with the DRNs, the DCNs, and the DQNs, the proposed DONs have better convergence and higher classification accuracy. The success of DONs is also explained by multi-task learning. (C) 2020 Elsevier B.V. All rights reserved.

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  • 3.HIFUNet: Multi-class segmentation of uterine regions from MR images using global convolutional networks for HIFU surgery planning

    • 关键词:
    • Magnetic resonance imaging;Network coding;Convolutional neural networks;Decoding;Large dataset;Learning systems;Deep learning;Image segmentation;Convolutional networks;Encoder-decoder;Learning methods;Multi-class segmentations;Receptive fields;Shape and size;Surgery planning;Uterine fibroids
    • Zhang, Chen;Shu, Huazhong;Yang, Guanyu;Li, Faqi;Wen, Yingang;Zhang, Qin;Dillenseger, Jean-Louis;Coatrieux, Jean-Louis
    • 《IEEE Transactions on Medical Imaging》
    • 2020年
    • 39卷
    • 11期
    • 期刊

    Accurate segmentation of uterus, uterine fibroids, and spine from MR images is crucial for high intensity focusedultrasound(HIFU) therapybut remains still difficult to achieve because of 1) the large shape and size variations among individuals, 2) the low contrast between adjacent organs and tissues, and 3) the unknown number of uterine fibroids. To tackle this problem, in this paper, we propose a large kernel Encoder-Decoder Network based on a 2Dsegmentationmodel. The use of this large kernel can capturemulti-scale contextsby enlarging the valid receptive field. In addition, a deep multiple atrous convolution block is also employed to enlarge the receptive field and extract denser feature maps. Our approach is compared to both conventional and other deep learning methods and the experimental results conducted on a large dataset show its effectiveness. © 2020 International Union of Crystallography. All rights reserved.

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  • 4.Measurement of Glomerular Filtration Rate Using Multiphasic Computed Tomography in Patients With Unilateral Renal Tumors: A Feasibility Study

    • 《FRONTIERS IN PHYSIOLOGY》
    • 2019年
    • 10卷
    • 期刊

    Objectives: This study was to assess the feasibility of a modified multiphasic CT scan protocol combined with homemade software measurements of glomerular filtration rate (CT-GFR) and explore the effect of renal tumor volume on the calculation of CT-GFR.Materials and Methods: Prospective observational study comparing three methods of GFR measurement from February 2017 to December 2017, 91 patients with unilateral renal tumor underwent both a modified multiphasic CT scans of kidney and serum creatinine (Scr) tests preoperatively, of which 15 cases underwent additional radionuclide examination. Total and split CT-GFR, with or without renal tumor, were quantified by the homemade software in early and late renal parenchymal phases, respectively. The volume of renal tumor was quantified by the homemade software. Correlation and difference between CT-GFR and traditional methods of GFR measurement, including estimated GFR (eGFR) from Scr concentration and split GFR using of radionuclide examination (R-GFR), were performed.Results: There is a strong correlation between CT-GFR with renal tumor and eGFR (r = 0.90, p < 0.001) in early renal parenchymal phase. The relative CT-GFR in early renal parenchymal phase was highly correlated with the relative R-GFR (r = 0.88, p < 0.001). Renal tumor volume significantly correlated with the value of CT-GFR that determined by subtracting the CT-GFR measurement without renal tumor from CT-GFR measurement with renal tumor (r = 0.89, p < 0.001).Conclusion: A modified multiphasic CT scan protocol combined with homemade software might be an alternative technique for the evaluation of renal function for the patients with unilateral renal tumor.

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