DSA融合引导支架实时精确定位

项目来源

国家重点研发计划(NKRD)

项目主持人

舒华忠

项目受资助机构

东南大学

立项年度

2017

立项时间

未公开

项目编号

2017YFC0107903

项目级别

国家级

研究期限

未知 / 未知

受资助金额

54.00万元

学科

数字诊疗装备研发

学科代码

未公开

基金类别

未公开

主动脉夹层 ; 卷积神经网络 ; 多平面重建 ; DSA融合引导支架 ; 医学影像配准 ; 成像角度优化 ; Aortic dissection ; Convolutional neural network ; Multi-plane reconstruction ; DSA fusion guidance stent ; Medical image registration ; Optimization of imaging angle

参与者

杨冠羽;李松毅;杨淳沨

参与机构

东南大学计算机科学与工程学院

项目标书摘要:主动脉夹层是一类高危的主动脉血管疾病,致死率很高。胸主动脉腔内修复术(TEVAR)因其微创伤和良好的真腔重塑效果而成为B型主动脉夹层治疗的首选方法和研究热点。主动脉夹层术前诊断规划及术后治疗需要客观量化结构参数、精准定位撕裂内膜和撕裂口位置等过程。CT 图像主动脉夹层的分割对于术前诊断、手术规划以及术后修复等具有重要的指导意义。病变紧邻主动脉弓部位三根重要分支动脉,覆膜容易堵住这些分支动脉而引发严重的并发症,为此在TEVAR手术中DSA成像角度的选取对于放置支架位置有着至关重要的影响。本文解决的关键技术有:1)提出一种基于多平面重建的3D MPRNet卷积神经网络架构,实现主动脉及撕裂内膜的精准及连续分割。2)建立线性组合相关性测度,通过共轭方向加速优化算法,实现CTA与DSA数据的精确配准。3)研究手术操作过程中影像漂移现象以及动态实时匹配的难题,构建医生、术前血管造影数据投影相对于术中DSA的位置和方向角,以及成像系统的内部参数,实现C型臂最佳成像角度优化;研究DSA与CTA影像的投影关系,并获得分支动脉的开口与支架的真实三维坐标,实现支架远末端在三维模型中的定位。4)通过流向跟踪法选取主动脉弓平面并计算其投影缩短率,构建投影平面正则化能量函数,优化最小缩短率、最小遮盖率和最大邻近间距,获取主动脉弓平面垂直成像角度。

Application Abstract: Aortic dissection is a high-risk aortic disease with high mortality.Thoracic endovascular aortic repair(TEVAR)has become the first choice and research focus for the treatment of type B aortic dissection due to its microtrauma and good remodeling effect.Preoperative diagnostic planning and postoperative treatment of aortic dissection require objective quantification of structural parameters,accurate positioning of the tearing intima and the location of the tear.Segmentation of aortic dissection in CT images is of great significance for preoperative diagnosis,surgical planning and postoperative repair.The lesion is adjacent to the three important branches of the aortic arch,and the coating is likely to block these branches and cause serious complications.Therefore,the selection of DSA imaging Angle in TEVAR surgery has a crucial impact on the placement of stents.Key technologies addressed in this paper include:1)A 3D MPRNet convolutional neural network architecture based on multi-plane reconstruction was proposed to achieve accurate and continuous segmentation of aorta and torn intima.2)The correlation measure of linear combination is established,and the precise registration of CTA and DSA data is realized through the accelerated optimization algorithm of conjugate direction.3)The problem of image drift and dynamic real-time matching during surgical operation was studied,and the position and direction Angle of the projection of the doctor and preoperative angiography data relative to intraoperative DSA as well as the internal parameters of the imaging system were constructed to optimize the optimal imaging Angle of c-arm.The projection relationship between DSA and CTA images was studied,and the real 3d coordinates of branch artery openings and stents were obtained to realize the positioning of the distal end of stents in the 3d model.4)The problem of image drift and dynamic real-time matching during surgical operation was studied,and the position and direction Angle of the projection of the doctor and preoperative angiography data relative to intraoperative DSA as well as the internal parameters of the imaging system were constructed to optimize the optimal imaging Angle of c-arm.The projection relationship between DSA and CTA images was studied,and the real 3d coordinates of branch artery openings and stents were obtained to realize the positioning of the distal end of stents in the 3d model.

项目受资助省

江苏省

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