项目标书摘要：Project C04 will address the concept that osteoclasts during inflammation could stem from bone marrow-derived cells,while resident embryonic precursors give rise to osteoclasts under steady state conditions.A major question that should be addressed in this project is whether these different osteoclast sub-populations display not only different origins,but also divergent activation profiles and functions.Such insights into osteoclast heterogeneity might provide a better understanding of osteoclast-related pathologies during inflammatory diseases as well as new targets for more specific therapeutic interventions during diseases such as RA and periodontitis.
Application Abstract: Project C04 will address the concept that osteoclasts during inflammation could stem from bone marrow-derived cells,while resident embryonic precursors give rise to osteoclasts under steady state conditions.A major question that should be addressed in this project is whether these different osteoclast sub-populations display not only different origins,but also divergent activation profiles and functions.Such insights into osteoclast heterogeneity might provide a better understanding of osteoclast-related pathologies during inflammatory diseases as well as new targets for more specific therapeutic interventions during diseases such as RA and periodontitis.
