PAI-1、MMP2与腹膜透析相关性腹膜纤维化的研究
项目来源
陕(略)学(略)究(略)划
项目主持人
金(略)
项目受资助机构
陕(略)民(略)
立项年度
2(略)
立项时间
未(略)
项目编号
2(略) SF-123
项目级别
省(略)
研究期限
未(略) (略)
受资助金额
5(略)万(略)
学科
肾(略)
学科代码
3(略)2(略)
基金类别
社(略)科(略)
关键词
纤(略)激(略)制(略) (略)质(略)白(略);(略)透(略) (略)维(略) (略) (略)l(略)i(略)e(略)c(略)a(略) (略)i(略)o(略) (略)a(略)x(略)t(略)o(略)t(略)s(略) (略)e(略)o(略)l(略)a(略)i(略) (略)r(略)r(略)n(略) (略)r(略)s(略)c(略)e(略)i(略)
参与者
未(略)
参与机构
未(略)
项目标书摘要:目的(略)物1(PAI-1)(略)MP2)与腹膜透析(略)法回顾性分析我院2(略)年4月长期规律随访(略)的临床资料,依据患(略)为腹膜纤维化组(n(略)组(n=62)。对(略)年龄、原发病(急性(略)合并疾病(糖尿病、(略))、营养状况(良好(略)、吸烟史、腹部手术(略)SS阻滞剂、腹膜透(略)BMI)、收缩压((略)P)]及实验室检查(略)T)、谷草转氨酶((略)MMP2]差异,绘(略)-1、MMP2预测(略)值,通过Logis(略)-1、MMP2是否(略)危险因素,最后以S(略)分析PAI-1、M(略)RP)、白介素-6(略)因子-α(TNF-(略)别、原发病、合并疾(略)吸烟史、腹部手术史(略)S阻滞剂、年龄、腹(略)BP、DBP、AL(略)计学意义(P>0.(略)液及腹膜透出液PA(略)著高于非腹膜纤维化(略)P54.265、5(略)3.565、3.6(略)化的危险因素。经相(略)MMP2与CRP、(略)现出正相关,均有((略)膜透析患者腹膜纤维(略)2密切相关,PAI(略)早期腹膜纤维化预测(略)该指标能更好的保护(略)。
Applicati(略): Objecti(略) the corr(略)ween PAI-(略)and perit(略)sis in pe(略)alysis.Me(略)cal data (略)ents with(略) dialysis(略)ollowed u(略) from Apr(略)April 201(略)spital we(略)ctively a(略)ients wer(略)nto perit(略)sis group(略)on-perito(略)is group((略)ing to wh(略)had perit(略)sis or no(略)he two gr(略)ic inform(略)r,age,pri(略)e(acute k(略)y,chronic(略)ure),comb(略)e(diabete(略)ion,hyper(略)eritoniti(略)nal statu(略)rate,poor(略)history,H(略)moking,hi(略)dominal s(略)ia,use of(略)ers,perit(略)sis time,(略)ndex(BMI)(略)lood pres(略)iastolic (略)ure(DBP),(略)ory tests(略)inotransf(略)aspartate(略)ferase(AS(略)P2]differ(略)ng the RO(略)analyze t(略) PAI-1 an(略)redicting(略) fibrosis(略)eal dialy(略)c regress(略)s of whet(略)nd MMP2 a(略)tors for (略)fibrosis (略)al dialys(略)the corre(略)een PAI-1(略)nd C-reac(略)n(CRP),in(略)(IL-6)and(略)osis fact(略)was analy(略)rman corr(略)fficient.(略)re was no(略)t differe(略)primary d(略)lication (略)ritional (略)king hist(略) history,(略)peration (略)mia,using(略)er,age,pe(略)alysis ti(略)DBP,ALT,A(略)the two g(略)5).The le(略)-1 and MM(略) and peri(略)sion of p(略)ibrosis g(略)ignifican(略)than thos(略)ritoneal (略)oup(P54.2(略)n blood a(略)al effusi(略)65 and 3.(略)sk factor(略)oneal fib(略)ritoneal (略) correlat(略)s,PAI-1 a(略)e positiv(略)ted with (略)d TNF-alp(略)Conclusio(略)l fibrosi(略)ts with p(略)ialysis i(略)elated to(略)MMP2.Pai-(略)can be bi(略)r the pre(略)early per(略)rosis,and(略)
项目受资助省
陕(略)
- (略)