新骨···活性···子的···功能··

项目来源

国家···学基···SF··

项目主持人

岳建·

项目受资助机构

中国···上海···究所

立项年度

2015

立项时间

未公开

项目编号

21···00·

研究期限

未知 / 未知

项目级别

国家·

受资助金额

300.00万元

学科

化学··-合成··

学科代码

B-B01

基金类别

重点··

关键词

活性···新骨···;药···结构···活性···天然···

英文关键词

Na···al···od···s;··· c···on···el···n;···ac···e ···ee···g;···ac···e ···po···s;···d ···ds·

参与者

刘群···巍;···;吴···耀月···海;···;王···周彬·

参与机构

中国···上海···药物·

项目标书摘要:本项···用基···植物···径和···导向···架天···化合···与研···略,···生物···向的···本策···显著···现新···构的···也保···现活···物的···由于···用植···首先···源途···构双···析研···大量···中选···种含···结构···;再···代分···、波···化学···筛选···学相···其进···的研···在发···免疫···活性···型和···的化···对重···物质···统的···饰、···系和···究,···期发···先导···候选···的预···包括···获得···合物···-4···,其···构1···20···新骨···的化···5-···;2···具有···物活···合物···25···得药···化合···物候···3个···望能···阐明···用植···效物···;3···结果···要国···上发···论文···专利·

We···ll···nd··· t··· p···ec···o ···lo···th···io···ic···pr···rt···,e···ci···y ··· i···no···pr···iv···ct···ty···d ··· u···rl···g ···en···l ···me···al···pl···ti···of···e ···po···s ···la··· f··· C···es···ed···na···la···,w···h ···ta··· s···ct···ll···iv···e ··· n···l ···po···s ···ed··· o···st···eg···f ··· b···yn···si···nd···ru···re···re···d ···ly···.O···st···eg···s ···fe···t ···m ··· b···ct···ty···id···is···ti···it···t ···y ···vi··· a···g ···or···it···o ···d ···po···s ···h ··· c···on···el···ns···t ···o ···e ···h ···es··· h···bi···gi··· c···ou··· d···to···e ···dy··· b···d ···me···in···pl···s.··· r···ar···ob···ti··· a···in···di···To···ni···th···he···al···ud···nd···ol···ca···es···in···rt···la···he···st···f ···un···pp···si···ac···it···n ···Ch···se···di···al···rb···el···ed··· c···ai···tr···ur···y ···er···an···ov···co···un···fr···a ··· n···er··· T···pl···s.··· a···mp···hm··· o···hi···ro···t ···l ···d ···th···so···io···f ··· t···00···ru···ra··· d···rs···om···nd···nc···in···50··· 2···ne···tr···ur···of···ic···5 ···20···mp···ds···ll···ss··· n···ca···n ···le···s;··· i···ti···at··· 2···o ···bi···gi···ly···po···nt···mp···nt···tr···ur···mo···ic···on···ru···re···ti···y ···at···sh···an···n ···de··· p···ma···ti··· s···y ···th···io···ic···y ···or···t ···po···s ···nt···ed··· t···pr···ct···ll··· c···ie···ut···d ···o ···ru···ea···or···ug···nd···te···il···e ···ef···y ···or··· s···eq···tl···he···se···h ···ul···wi···pu···sh···se···h ···er···n ··· i···rn···on···to···ou···ls···d ···ly···te···.I···dd···on···nu···r ···Ph···tu···ts···d ···e ···th···ou···sc···ti··· w··· b···ra···d ···m ··· s···es···l ···pl···on··· t··· p···ec··

项目受资助省

上海·

  • 排序方式:
  • 6
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  • 1.重要···合物···与生···的全··

    • 期刊

    <正···化合···类型···具有···要生···,作···药物···例子···。我···小组···研究···了大···类化···包括···物碱···结构···样、···具有···杂的···体系···化合···多种···物活···五年···过对···种富···的药···进行···化学···究,···50···新化···特别···了多···架类···有重···的天···物,···疟疾···瘤、···制和···病等···。对···化合···源合···了探···对其···些重···萜类···进行···启发···成研···6。

    ...
  • 6.Ce···lo···ne···-D···om···nd···ar···er···ti···an···em···nt···is··· [···] ···lo···it···

    • 关键词:
    • [6+6]-cycloaddition; C-19-norditerpenoid dimers; natural products;semisynthesis; Th17 cell differentiation;NATURAL-PRODUCTS; C-2 SYMMETRY; CEPHALOTAXUS; TROPONE; NORDITERPENOIDS;HARRINGTONOLIDE; DITERPENOIDS; SKELETON; DIMERS
    • Ge···ha···en···an···ao···e;···g,···n-···Zh···, ···ng···;L···Ti···Yu···Ji···Mi·
    • 《AN···AN··· C···IE···TE···TI···L ···TI··》
    • 2021年
    • 60卷
    • 17期
    • 期刊

    Ce···lo···ne···-D···-4···th···ir···ex···le··· C···-n···it···en··· d···rs···er···so···ed···d ···ly···ar···er···d ···m ···ep···ot···s ···nt···he···ne···ke···al···tu··· p···uc···sh···d ···ni··· t···yc···6.···.1···7)···tr···ca···5,···1-···ra···-1···4-···ne···re···at···s ···pe···n ···h ···s ···h ···id···lt···cl···ri···sy···ms···th···C-···ym···ri···ly··· a···me···ca···. ···po···s ··· w··· p···os···to··· b···yn···ti···ly···od···d ···th···6+···cy···ad···io···f ··· i···ti··· C···-n···it···en··· t···on···s,···ic···as···li···ed··· t···se···yn···se···f ···er···-4···or···er···om···om···nd···ho··· s···if···nt···hi···io···n ···7 ···l ···fe···ti···on·

    ...
  • 7.Di···ve···of···ur···di···d ···ss···of···it···en···s ···in···ed···me···ol···ca···de···om···nd···ar···er···ti···an···io···et···sy···es··

    • 关键词:
    • Cell culture;Chemical modification;Tumors;Synthetic aperture radar;Biomimetics;Biomimetic synthesis;Biosynthetic pathway;Chemical events;Cytotoxic activities;Diverse methods;Functional motifs;Structure-activity relationships;Tumor cell lines
    • Zh··· B···Ga···Xi···ua···an···Mi···in···en···Ch···-Y···iu···on···hu···ue···ia···in
    • 《Ch···ca···ci···e》
    • 2021年
    • 12卷
    • 28期
    • 期刊

    ···iv···co··· T···Ro··· S···et···f ···mi···y ···1.

    ...
  • 8.Di···se···te···no··· f··· M···od···is···se···fo···

    • 关键词:
    • Microdesmis casearifolia; Microdesmis genus; diterpenoid; casearoids Asimilar to D; spectroscopic analysis; electronic circular dichroism(ECD) analysis;KEAYANA; DERIVATIVES; CEMBRANOLIDES; LEAVES; ROOTS; PLANT
    • Ha···Gu···hu···en···uh···Fa···Ya···e;··· K···on···ho···Bi···ao···ei···;Y··· J···mi·
    • 《CH···SE···UR··· O···RG···C ···MI···Y》
    • 2020年
    • 40卷
    • 9期
    • 期刊

    Fo···ne···it···en···s,···se···id··· s···la···o ···1 ···il···to···, ···lu···g ···ab···e,···os···, ···da··· a···ce···an···we···is···te···nd···ar···er···d ···m ···cr···sm···ca···ri···ia···he···st···tu··· w··· e···id···d ···ex···si···sp···ro···pi···at···na···is···he···so···e ···fi···at···s ···th··· d···rp···id···er···st···is··· b···na···is··· t···el···ro··· c···ul···di···oi···(E··· d···.

    ...
  • 9.Li···oi···fr···Ci···es···ba···fe··

    • 关键词:
    • A-D; TETRANORTRITERPENOIDS; SKELETONS; CHEMISTRY; SEEDS
    • Yu···in···i;···ng···ua···ou···in···mb···, ···vi···.;···al···ee···Li···Qu···an···as···a,···ri···.;···, ···n-···
    • 《JO···AL··· N···RA···RO···TS》
    • 2020年
    • 83卷
    • 6期
    • 期刊

    Ei···ee···ew···mo···ds···nc···in···ig···me···l ···ol···at···(1··· a···10···pa···in···9-···, ···e ···la··· f··· t···le···s ···Ci···es···ba···fe··· T···r ···uc···es···re···ar···er···d ···me··· o···pe···os···ic···ta···al···s,···ng···cr···al···ra···if···ct···, ··· q···tu···he···tr···om···at···al···th···. ··· C···co···gu···io···in···os···om···nd···os···si···a ··· h···ox···ro···we···al···ss···ed··· S···ga···es···f ··· m···it··· o···(5···, ··· t···C-···co···gu···io···n ···se···ar··· a···me···lb···ry···es···e ··· d···ne···y ···gl···ry···l ···ay···ff···ti···an···MR···ta···om···nd···, ···6,··· 1···an···2 ···we···od···te···ti···ar··· a···vi···s ···h ···0 ···ue···an···g ···m ···to··· m···.

    ...
  • 10.Cr···no··· A··· A···gh···Re···an··· a···Du···Br···ed···ir···it···en··· a···Tw···th···Di···pe···ds···om···ot···ko···ns··

    • Fa···Ya···ue···i,···u-···;D···, ···-Z···;L··· H···-C···;X···Ch···-H···Di··· J···;W···, ···n-···Yu···Ji···Mi·
    • 《OR···IC···TT···》
    • 2020年
    • 22卷
    • 3期
    • 期刊

    Cr···no···A ···, ···ig··· r···ra···d ···er···oi···ea···in··· d···-b···ge···ri···lo···4.···(1···]d···ca···2,···di··· r··· s···em···d ··· t···po···bl···nt···ur··· d···rp···id···ec···or···2 ··· 3···wa···so···ed···d ···uc···al···ch···ct···ze···y ···id···ta···om···ot···ko···ns··· C···ou···1 ···ib···d ···ni···an···yt···xi···y ···in···HL··· a···A-··· c··· l···s ···h ···0 ···ue···f ···4 ··· 0··· a···1.···+/···.6···u ···re···ct···ly·

    ...
  • 排序方式:
  • 6
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