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党参与三七补气活血功效物质解析及深度研发

项目来源

国家重点研发计划(NKRD)

项目主持人

张俊华

项目受资助机构

中国医学科学院药用植物研究所

立项年度

2022

立项时间

未公开

项目编号

2022YFC3501803

研究期限

未知 / 未知

项目级别

国家级

受资助金额

340.00万元

学科

中医药现代化

学科代码

未公开

基金类别

未公开

关键词

党参 ; 三七 ; 核心功效 ; 功能因子 ; 作用机制 ; Codonopsis pilosula ; Panax notoginseng ; Core efficacy ; Functional factors ; Mechanism of action

参与者

陈荣昌

参与机构

中国中医科学院中药研究所；山西振东制药股份有限公司

项目标书摘要：本课题以“补气”“活血”传统功效为导向，以中医气血理论为指导，从党参、三七的临床定位与疗效优势出发，运用多种气虚/血瘀/出血模型，从分子、细胞及动物水平上，整合“多模态成像—空间分子分析—靶标发现”等技术，系统性诠释其传统功效—功能因子—作用机制的关联，全景式解析党参“补中益气”及三七“活血止血”的“功效物质”关系，为体系化阐释中药材传统功效的物质基础和现代生物学机制提供实验范例。目前主要进行了党参抗衰老和抗疲劳作用研究、三七对脑小血管病变保护作用及潜在靶点研究及三七治疗心肌缺血的潜在药效物质及靶点研究，基于多组学技术联合分析及分子生物学验证，初步发现了党参抗疲劳及抗衰老活性部位及可能机制，以及三七治疗脑小血管病变及心肌缺血的潜在靶点。

Application Abstract: This project is guided by the traditional efficacy of"tonifying qi"and"promoting blood circulation",guided by the theory of traditional Chinese medicine's Qi and blood.Starting from the clinical positioning and therapeutic advantages of Codonopsis pilosula and Panax notoginseng,multiple Qi deficiency/blood stasis/bleeding models are used to integrate technologies such as"multimodal imaging spatial molecular analysis target discovery"at the molecular,cellular,and animal levels,systematically interpreting the correlation between their traditional efficacy functional factors mechanism of action,A panoramic analysis of the relationship between the"functional substances"of Codonopsis pilosula"tonifying the middle and nourishing qi"and Sanqi"promoting blood circulation and stopping bleeding"provides an experimental example for the systematic interpretation of the material basis and modern biological mechanisms of traditional Chinese medicinal materials.At present,research has mainly been conducted on the anti-aging and anti-fatigue effects of Codonopsis pilosula,the protective effect and potential targets of Panax notoginseng on cerebral small vessel lesions,and the potential pharmacological substances and targets of Panax notoginseng for treating myocardial ischemia.Based on multi omics technology combined analysis and molecular biology verification,the active sites and possible mechanisms of Codonopsis pilosula for anti-fatigue and anti-aging have been preliminarily discovered,as well as the potential targets of Panax notoginseng for treating cerebral small vessel lesions and myocardial ischemia.

项目受资助省

北京市

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  • 1.党参和三七有效部位及活性成分药理作用及机制研究(Pharmacological effects and mechanisms of the effective parts and active ingredients of Codonopsis pilosula and Panax notoginseng)

    • 关键词：
    • 党参、三七、核心功效、功能因子、作用机制、Codonopsis pilosula、Panax notoginseng、Core efficacy、Functional factors、Mechanism of action
    • 陈荣昌；
    • 《中国医学科学院药用植物研究所；》
    • 2023年
    • 报告

    本课题以“补气”“活血”传统功效为导向，以中医气血理论为指导，从党参、三七的临床定位与疗效优势出发，运用多种气虚/血瘀/出血模型，从分子、细胞及动物水平上，整合“多模态成像—空间分子分析—靶标发现”等技术，系统性诠释其传统功效—功能因子—作用机制的关联，全景式解析党参“补中益气”及三七“活血止血”的“功效物质”关系，为体系化阐释中药材传统功效的物质基础和现代生物学机制提供实验范例。目前主要进行了党参抗衰老和抗疲劳作用研究、三七对脑小血管病变保护作用及潜在靶点研究及三七治疗心肌缺血的潜在药效物质及靶点研究，基于多组学技术联合分析及分子生物学验证，初步发现了党参抗疲劳及抗衰老活性部位及可能机制，以及三七治疗脑小血管病变及心肌缺血的潜在靶点。This project is guided by the traditional efficacy of"tonifying qi"and"promoting blood circulation",guided by the theory of traditional Chinese medicine's Qi and blood.Starting from the clinical positioning and therapeutic advantages of Codonopsis pilosula and Panax notoginseng,multiple Qi deficiency/blood stasis/bleeding models are used to integrate technologies such as"multimodal imaging spatial molecular analysis target discovery"at the molecular,cellular,and animal levels,systematically interpreting the correlation between their traditional efficacy functional factors mechanism of action,A panoramic analysis of the relationship between the"functional substances"of Codonopsis pilosula"tonifying the middle and nourishing qi"and Sanqi"promoting blood circulation and stopping bleeding"provides an experimental example for the systematic interpretation of the material basis and modern biological mechanisms of traditional Chinese medicinal materials.At present,research has mainly been conducted on the anti-aging and anti-fatigue effects of Codonopsis pilosula,the protective effect and potential targets of Panax notoginseng on cerebral small vessel lesions,and the potential pharmacological substances and targets of Panax notoginseng for treating myocardial ischemia.Based on multi omics technology combined analysis and molecular biology verification,the active sites and possible mechanisms of Codonopsis pilosula for anti-fatigue and anti-aging have been preliminarily discovered,as well as the potential targets of Panax notoginseng for treating cerebral small vessel lesions and myocardial ischemia.

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