项目来源
韩国国家研究基金(NRF)
项目主持人
장춘곤
项目受资助机构
성균관대학교
项目编号
2009-013-E00056
立项年度
2009
立项时间
未公开
项目级别
国家级
研究期限
未知 / 未知
受资助金额
未知
学科
의약학
学科代码
未公开
基金类别
人文社科-SD-Research
关键词
자가투여법 ; 보상 ; 약물의존 ; 필로폰 ; 약물남용 ; 약물자가투여 ; 약물중독 ; 재발 ; drug dependence ; methamphetamine ; reward ; self-administration ; drug abuse ; TRPV1
参与者
장춘곤
参与机构
未公开
项目标书摘要：Research Summary:The purpose of this study is to understand the reward mechanism of methamphetamine modulated by TRPV1 receptors and to learn the self-administration test which is the newest research skills and core skills in drug abuse.Methamphetamine self-administration established by conductiing FR,PR,and reinstatement schedules.TRPV1 antagonists,capsazepine and SB366791 inhibited reinstatement of methamphetamine-self administaration.During early withdrawal period from methamphetamine,rat showed depressive-like behavior,and after 2 weeks withdrawal from methamphetamine,the rats showed anxiogenic behavior.Also,new dopamine agonist,PKF-205,152 inhibited the methamphetamine self-administration in PR schedule.Taken together.these results suggest that TRPV1 receptors may be developed as a novel target for treatment of drug dependence.
Application Abstract: Research Summary:The purpose of this study is to understand the reward mechanism of methamphetamine modulated by TRPV1 receptors and to learn the self-administration test which is the newest research skills and core skills in drug abuse.Methamphetamine self-administration established by conductiing FR,PR,and reinstatement schedules.TRPV1 antagonists,capsazepine and SB366791 inhibited reinstatement of methamphetamine-self administaration.During early withdrawal period from methamphetamine,rat showed depressive-like behavior,and after 2 weeks withdrawal from methamphetamine,the rats showed anxiogenic behavior.Also,new dopamine agonist,PKF-205,152 inhibited the methamphetamine self-administration in PR schedule.Taken together.these results suggest that TRPV1 receptors may be developed as a novel target for treatment of drug dependence.
