Developmental Research Project(DRP)Program
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1.Editorial: Coding and non-coding RNA-based complexes in organismal development and disease pathogenesis
- 关键词:
- RNA regulation; disease; development; coding RNAs; non-coding RNAs
2.Complete Genome Sequences of Mycobacterium smegmatis Phages MelsMeow, Yorick, Virgeve, and Mikro.
- 关键词:
- ;
Mycobacterium phages Mikro, Yorick, Virgeve, and MelsMeow were isolated from soil in Rock Hill, South Carolina. Mikro is a myovirus with a comparatively large genome of 157,166bp. The remainder are siphoviruses with genome lengths ranging from 59,227bp to 68,563bp. All phages were isolated on Mycobacterium smegmatis.
...3.Identification of Small Regulatory RNA Transcripts in Extracellular Vesicles from Lactic Acid Bacteria
4.Control of Fibrotic Gene Expression in Cardiac Myocytes and Fibroblasts via the Rap1 GTPase
5.Identification and Characterization of Small Regulatory RNA in Streptococcus
6.Lysophosphatidic Acid Signalling in Nervous System Development and Function
- 关键词:
- LPA receptors; Autotaxin; Cortical development; Axon guidance;Neuropathic pain; Lysophospholipid;PROTEIN-COUPLED RECEPTOR; INDUCED NEURITE RETRACTION; PLAYS KEY ROLES;NEUROPATHIC PAIN; GROWTH CONES; SPINAL-CORD; CHEMOTROPIC RESPONSES;BIOLOGICAL-ACTIVITIES; EXPRESSION PATTERNS; GENE-EXPRESSION
One class of molecules that are now coming to be recognized as essential for our understanding of the nervous system are the lysophospholipids. One of the major signaling lysophospholipids is lysophosphatidic acid, also known as LPA. LPA activates a variety of G protein-coupled receptors (GPCRs) leading to a multitude of physiological responses. In this review, I describe our current understanding of the role of LPA and LPA receptor signaling in the development and function of the nervous system, especially the central nervous system (CNS). In addition, I highlight how aberrant LPA receptor signaling may underlie neuropathological conditions, with important clinical application.
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