Integrated Training in Cancer Model Systems
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1.Long-term Survival in Head and Neck Cancer: Impact of Site, Stage, Smoking, and Human Papillomavirus Status
- 关键词:
- Head and neck neoplasms; oropharynx; survival; smoking; humanpapillomavirus;AMERICAN JOINT COMMITTEE; OROPHARYNGEAL CANCER; HPV; RISK; CARCINOMA;CIGARETTE; SYSTEM; DEATH
- Du, Eugenie;Mazul, Angela L.;Farquhar, Doug;Brennan, Paul;Anantharaman, Devasena;Abedi-Ardekani, Behnoush;Weissler, Mark C.;Hayes, David N.;Olshan, Andrew F.;Zevallos, Jose P.
- 《Annual Meeting of the American-Head-and-Neck-Society at theCombined Otolaryngology Spring Meetings 》
- 2019年
- APR 26-30, 2017
- San Diego, CA
- 会议
Objectives/Hypothesis Literature examining long-term survival in head and neck squamous cell carcinoma (HNSCC) with human papillomavirus (HPV) status is lacking. We compare 10-year overall survival (OS) rates for cases to population-based controls. Study Design Prospective cohort study. Methods Cases surviving 5 years postdiagnosis were identified from the Carolina Head and Neck Cancer Study. We examined 10-year survival by site, stage, p16, and treatment using Kaplan-Meier and Cox proportional hazard models. Cases were compared to age-matched, noncancer controls with stratification by p16 and smoking status. Results Ten-year OS for HNSCC is less than controls. In 581 cases, OS differed between sites with p16+ oropharynx having the most favorable prognosis (87%), followed by oral cavity (69%), larynx (67%), p16- oropharynx (56%), and hypopharynx (51%). Initial stage, but not treatment, also impacted OS. When compared to controls matched on smoking status, the hazard ratio (HR) for death in p16+ oropharynx cases was 1.5 (95% confidence interval [CI]: 0.7-3.1) for smokers and 2.4 (95% CI: 0.7-8.8) for nonsmokers. Similarly, HR for death in non-HPV-associated HNSCC was 2.2 (95% CI: 1.7-3.0) for smokers and 2.4 (95% CI: 1.4-4.9) for nonsmokers. Conclusions OS for HNSCC cases continues to decrease 5 years posttreatment, even after stratification by p16 and smoking status. Site, stage, smoking, and p16 status are significant factors. These data provide important prognostic information for HNSCC. Level of Evidence 2 Laryngoscope, 129:2506-2513, 2019
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