项目来源

国家重点研发计划(NKRD)

项目主持人

丁斐

项目受资助机构

南通大学

项目编号

2017YFA0104700

立项年度

2017

立项时间

未公开

研究期限

未知 / 未知

项目级别

国家级

受资助金额

2685.00万元

学科

干细胞及转化研究

学科代码

未公开

基金类别

“干细胞及转化研究”重点专项

关键词

干细胞 ; 神经损伤 ; 生物材料 ; stem cell ; nerve injury ; biomaterial

参与者

于彬；尚爱加；赖碧琴；沈宓

参与机构

中国人民解放军总医院；中山大学

项目标书摘要：神经损伤的修复是临床治疗中的世界性难题。神经损伤修复是涉及许多细胞活动的复杂过程，不仅需要“桥梁”引导再生神经纤维跨越缺损部位，还需要创造合适的“微环境”以利于再生。基于干细胞的组织工程技术为其治疗提供了新的策略。本项目从神经损伤后再生微环境变化规律和特征入手，阐述了干细胞对再生微环境的调控及相互作用；采用干细胞结合生物材料的技术，构建了基于干细胞的神经组织模块用于修复周围神经长距离缺损和脊髓损伤，评价其有效性和安全性；阐述了干细胞神经组织模块重建再生微环境、诱导神经生长、修复神经损伤的生物学机制。为进一步制定技术规范，建立临床评价体系，实现临床转化提供基础，为临床难以治疗的神经损伤修复提供新的技术。

Application Abstract: Nerve injury repair is a worldwide problem in clinical practice.The repair,a complex process involving many cellular activities,requires the construction of a"bridge"across the defect to guide axonal growth and the recreation of a suitable"microenvironment"to facilitate nerve regeneration.Stem-cell-based tissue engineering technology provides a new strategy for its treatment.This project focused on the elucidation of how stem cells regulated and interacted with the regenerative microenvironment by examining cellular and molecular changes within the lesioned sites during nerve repair.We constructed the stem-cell-based neural tissue module through unique procedures of incorporating stem cells into biocompatible scaffolds,and successfully implanted the module to peripheral nerve defect or injured spinal cord,followed by evaluation of repair outcomes and repair safety.We further investigated the possible biological mechanisms of rebuilding the regenerative microenvironment and promoting neural growth by the stem-cell-based nerve tissue module.The results we obtained will be helpful in formulating technical specifications,establishing a clinical evaluation system,and achieving clinical transformation for this new treatment strategy in further research and to provide a new therapeutic strategy for nerve injury repair

项目受资助省

江苏省

项目实施周期(年)

4.5