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全球科研项目数据库2026版

Administrative Core

项目来源

美国卫生和人类服务部基金(HHS)

项目主持人

KHEMTONG,CHALERMCHAI

项目受资助机构

UT SOUTHWESTERN MEDICAL CENTER

立项年度

2021

立项时间

未公开

项目编号

5P41EB01590833

项目级别

国家级

研究期限

未知 / 未知

受资助金额

77575.00美元

学科

Biotechnology

学科代码

未公开

基金类别

RESEARCH CENTERS

Administrator ; Advisory Committees ; Communication ; Communities ; Development ; Doctor of Philosophy ; Image ; Infrastructure ; Internet ; Metabolic ; Metabolism ; Mission ; Monitor ; NMR Spectroscopy ; National Institute of Biomedical Imaging and Bioengineering ; Occupational activity of managing finances ; Personnel Management ; Policies ; Preparation ; Procedures ; Progress Reports ; Recommendation ; Recovery ; Reporting ; Research ; Research Personnel ; Services ; Structure ; Time ; Tracer ; Training ; Update ; Work ; base ; cost ; equipment acquisition

参与者

KHEMTONG, CHALERMCHAI

参与机构

NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

项目标书摘要：dministrative Core Summary/AbstractThe Administrative Core is responsible for oversight and coordination of activities in the National Center for InVivo Metabolism.There are three aims:1.Administer the BTRC.This component will administer and coordinate general activities of the BTRC.Thefinancial administration,interactions with the Advanced Imaging Research Center(AIRC),communication withCollaborative Projects,communication with Service Projects,and interaction with NIBIB will all be supportedthrough the Administrative Core.One web programmer will be supported in the Administrative Core andresponsible for development,implementation,and support of the BTRC web page.2.Manage the Internal Advisory Committee(IAC).This Committee is composed of the leaders of the TR&Dprojects(Drs.Malloy,Sherry,Burgess,Kovacs and Wang)plus local experts with administrative support.TheIAC has multiple responsibilities.It will receive and evaluate applications for consideration as a CP or a SP,monitor instrument usage and assure appropriate chargebacks,systemically review progress in each one ofthe CPs on a rotating basis with a report on the assistance received from each TR&D,and oversee distributionof 13C and 15N tracers as they are developed.The IAC will advise Dr.Malloy and the leaders of each TR&Dproject.3.Manage the annual meeting of the External Advisory Committee(EAC).The EAC,described in more detailin the Administration section,will be composed of experts outside UT Southwestern.Each investigator in the TR&Ds brings a common interest in metabolism and NMR spectroscopy but alsocontributes highly distinctive strengths.The team is well-suited to serve the metabolic research community andthe BTRC.We have experience working together for many years and opinions can be shared candidly.We areconfident that that a well-integrated and responsive administrative structure can be provided to theCollaborators and Service investigators.

项目持续时间

33 years

项目负责机构类型

Domestic Higher Education

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  • 1.Ins and Outs of the TCA Cycle:The Central Role of Anaplerosis

    • 关键词：
    • CYTOSOLIC PHOSPHOENOLPYRUVATE CARBOXYKINASE; CITRIC-ACID CYCLE; ENDOGENOUS GLUCOSE-PRODUCTION; DE-NOVO LIPOGENESIS; PYRUVATE-CARBOXYLASE; KREBS CYCLE; RAT-LIVER; HEPATIC GLUCONEOGENESIS; ENERGY-METABOLISM; MITOCHONDRIAL METABOLISM
    • Inigo, Melissa;Deja, Stanislaw;Burgess, Shawn C.
    • 《ANNUAL REVIEW OF NUTRITION, VOL 41, 2021》
    • 2021年
    • 会议

    The reactions of the tricarboxylic acid (TCA) cycle allow the controlled combustion of fat and carbohydrate. In principle, TCA cycle intermediates are regenerated on every turn and can facilitate the oxidation of an infinite number of nutrient molecules. However, TCA cycle intermediates can be lost to cataplerotic pathways that provide precursors for biosynthesis, and they must be replaced by anaplerotic pathways that regenerate these intermediates. Together, anaplerosis and cataplerosis help regulate rates of biosynthesis by dictating precursor supply, and they play underappreciated roles in catabolism and cellular energy status. They facilitate recycling pathways and nitrogen trafficking necessary for catabolism, and they influence redox state and oxidative capacity by altering TCA cycle intermediate concentrations. These functions vary widely by tissue and play emerging roles in disease. This article reviews the roles of anaplerosis and cataplerosis in various tissues and discusses how they alter carbon transitions, and highlights their contribution to mechanisms of disease.

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