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全球科研项目数据库2026版

Administrative Core

项目来源

美国卫生和人类服务部基金(HHS)

项目主持人

KHEMTONG,CHALERMCHAI

项目受资助机构

UT SOUTHWESTERN MEDICAL CENTER

立项年度

2021

立项时间

未公开

项目编号

5P41EB01590833

项目级别

国家级

研究期限

未知 / 未知

受资助金额

77575.00美元

学科

Biotechnology

学科代码

未公开

基金类别

RESEARCH CENTERS

Administrator ; Advisory Committees ; Communication ; Communities ; Development ; Doctor of Philosophy ; Image ; Infrastructure ; Internet ; Metabolic ; Metabolism ; Mission ; Monitor ; NMR Spectroscopy ; National Institute of Biomedical Imaging and Bioengineering ; Occupational activity of managing finances ; Personnel Management ; Policies ; Preparation ; Procedures ; Progress Reports ; Recommendation ; Recovery ; Reporting ; Research ; Research Personnel ; Services ; Structure ; Time ; Tracer ; Training ; Update ; Work ; base ; cost ; equipment acquisition

参与者

KHEMTONG, CHALERMCHAI

参与机构

NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

项目标书摘要：dministrative Core Summary/AbstractThe Administrative Core is responsible for oversight and coordination of activities in the National Center for InVivo Metabolism.There are three aims:1.Administer the BTRC.This component will administer and coordinate general activities of the BTRC.Thefinancial administration,interactions with the Advanced Imaging Research Center(AIRC),communication withCollaborative Projects,communication with Service Projects,and interaction with NIBIB will all be supportedthrough the Administrative Core.One web programmer will be supported in the Administrative Core andresponsible for development,implementation,and support of the BTRC web page.2.Manage the Internal Advisory Committee(IAC).This Committee is composed of the leaders of the TR&Dprojects(Drs.Malloy,Sherry,Burgess,Kovacs and Wang)plus local experts with administrative support.TheIAC has multiple responsibilities.It will receive and evaluate applications for consideration as a CP or a SP,monitor instrument usage and assure appropriate chargebacks,systemically review progress in each one ofthe CPs on a rotating basis with a report on the assistance received from each TR&D,and oversee distributionof 13C and 15N tracers as they are developed.The IAC will advise Dr.Malloy and the leaders of each TR&Dproject.3.Manage the annual meeting of the External Advisory Committee(EAC).The EAC,described in more detailin the Administration section,will be composed of experts outside UT Southwestern.Each investigator in the TR&Ds brings a common interest in metabolism and NMR spectroscopy but alsocontributes highly distinctive strengths.The team is well-suited to serve the metabolic research community andthe BTRC.We have experience working together for many years and opinions can be shared candidly.We areconfident that that a well-integrated and responsive administrative structure can be provided to theCollaborators and Service investigators.

项目持续时间

33 years

项目负责机构类型

Domestic Higher Education

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  • 3.How the Chemical Properties of GBCAs Influence Their Safety Profiles In Vivo

    • 关键词：
    • gadolinium-based contrast agents; thermodynamic stability; kineticinertness; gadolinium deposition; T-1 hyperintensity;NEPHROGENIC SYSTEMIC FIBROSIS; T1-WEIGHTED MR-IMAGES; HIGH-SIGNALINTENSITY; NORMAL RENAL-FUNCTION; INTRACRANIAL GADOLINIUM DEPOSITION;POLYMETHYLATED DOTA LIGANDS; HUMAN BONE TISSUE; DENTATE NUCLEUS;CONTRAST AGENTS; GLOBUS-PALLIDUS

    The extracellular class of gadolinium-based contrast agents (GBCAs) is an essential tool for clinical diagnosis and disease management. In order to better understand the issues associated with GBCA administration and gadolinium retention and deposition in the human brain, the chemical properties of GBCAs such as relative thermodynamic and kinetic stabilities and their likelihood of forming gadolinium deposits in vivo will be reviewed. The chemical form of gadolinium causing the hyperintensity is an open question. On the basis of estimates of total gadolinium concentration present, it is highly unlikely that the intact chelate is causing the T-1 hyperintensities observed in the human brain. Although it is possible that there is a water-soluble form of gadolinium that has high relaxitvity present, our experience indicates that the insoluble gadolinium-based agents/salts could have high relaxivities on the surface of the solid due to higher water access. This review assesses the safety of GBCAs from a chemical point of view based on their thermodynamic and kinetic properties, discusses how these properties influence in vivo behavior, and highlights some clinical implications regarding the development of future imaging agents.

    ...

  • 4.How the Chemical Properties of GBCAs Influence Their Safety Profiles In Vivo

    • 关键词：
    • gadolinium-based contrast agents; thermodynamic stability; kineticinertness; gadolinium deposition; T-1 hyperintensity;NEPHROGENIC SYSTEMIC FIBROSIS; T1-WEIGHTED MR-IMAGES; HIGH-SIGNALINTENSITY; NORMAL RENAL-FUNCTION; INTRACRANIAL GADOLINIUM DEPOSITION;POLYMETHYLATED DOTA LIGANDS; HUMAN BONE TISSUE; DENTATE NUCLEUS;CONTRAST AGENTS; GLOBUS-PALLIDUS

    The extracellular class of gadolinium-based contrast agents (GBCAs) is an essential tool for clinical diagnosis and disease management. In order to better understand the issues associated with GBCA administration and gadolinium retention and deposition in the human brain, the chemical properties of GBCAs such as relative thermodynamic and kinetic stabilities and their likelihood of forming gadolinium deposits in vivo will be reviewed. The chemical form of gadolinium causing the hyperintensity is an open question. On the basis of estimates of total gadolinium concentration present, it is highly unlikely that the intact chelate is causing the T-1 hyperintensities observed in the human brain. Although it is possible that there is a water-soluble form of gadolinium that has high relaxitvity present, our experience indicates that the insoluble gadolinium-based agents/salts could have high relaxivities on the surface of the solid due to higher water access. This review assesses the safety of GBCAs from a chemical point of view based on their thermodynamic and kinetic properties, discusses how these properties influence in vivo behavior, and highlights some clinical implications regarding the development of future imaging agents.

    ...
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