Application Abstract: The research progress of this study this year mainly includes cascade registration strategy based on neural network models and disease prediction research methods based on deep learning models.The research group researched the problem of large deformation in brain images and the registration of complex local brain structures and proposed a cascaded registration strategy to solve the problem of large deformation.In the precision registration stage of the later stage of cascaded registration,the registration problem of local fine structures is solved by adjusting the constraints of the loss function.In addition,the research group also explored the potential of extracting brain MRI image features for disease prediction based on deep learning models,taking into account the background of the visiting study cooperation project.