UW Radiological Sciences Training Program

项目来源

美国卫生和人类服务部基金(HHS)

项目主持人

DAMICO, MARK W

项目受资助机构

UNIVERSITY OF WISCONSIN MADISON

立项年度

2019

立项时间

未公开

项目编号

2T32CA009206-41

研究期限

未知 / 未知

项目级别

国家级

受资助金额

493322.00美元

学科

Biomedical Imaging; Cancer;

学科代码

未公开

基金类别

TRAINING, INSTITUTIONAL

关键词

未公开

参与者

HALL, TIMOTHY J.

参与机构

NATIONAL CANCER INSTITUTE

项目标书摘要:Project Summary: This training program prepares eight predoctoral graduate students and three postdoctoral researchers for careers in the application of physics to the medical diagnosis and treatment of cancer. Available research specializations encompass broad areas of physics as applied to disease diagnosis, patient-specific treatment and assessment of treatment efficacy, and basic physics research applied to cancer. The 34 mentors and 17 other Participating Faculty in the Departments of Medical Physics, Radiology, Human Oncology (Radiation Oncology), Engineering Physics, and Biomedical Engineering maintain a broad spectrum of research collaborations with other clinical and basic science researchers. Translational, team-driven research includes traditional x-ray, CT, MRI, ultrasound, and PET imaging with the Department of Radiology, and radiation physics, radiation biology, and radiation therapy with the Departments of Physics, Nuclear Engineering, and Human Oncology. Trainees are intimate participants in these research programs as collaborators, publishing joint research articles, and performing as investigators in extramurally funded grants and contracts. Extensive faculty contact provides leadership and supervision. Beyond research activities, predoctoral trainees as graduate students in Medical Physics take at least twenty-six credits supportive of medical physics training and oriented towards their research specialization. Nominees for predoctoral positions in this training program typically have passed their preliminary examination of a proposed PhD research plan related to cancer. This significantly increases the likelihood of their remaining in cancer-related research and shortens their typical time in the NRSA position to about two years. Postdoctoral trainees are encouraged to broaden and deepen their academic training by auditing appropriate courses, and their appointments are typically 2-3 years. Both predoctoral and postdoctoral trainees must take or audit additional research ethics courses, cancer-specific courses, must attend relevant grand round presentations, and must participate in intensive workshops on manuscript writing and grant writing. Trainees give seminars, attend colloquia, present research results at local, national, and international meetings, and co-author articles and reports. An annual Training Grant Symposium provides additional opportunity for trainees to present research results to the Medical Physics and collaborating faculty. In this way trainees in this program are well prepared to assume leadership positions as researchers and academicians in the application of physics to cancer prevention, diagnosis, and treatment.

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  • 1.Adaptation of Dictionary Learning for Electrode Displacement Elastography

    • 关键词:
    • PERCUTANEOUS MICROWAVE ABLATION; RADIOFREQUENCY ABLATION; STRAIN ESTIMATION; EFFICACY; SAFETY; TUMORS
    • Pohlman, Robert M.;Varghese, Tomy
    • 《42ND ANNUAL INTERNATIONAL CONFERENCES OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY: ENABLING INNOVATIVE TECHNOLOGIES FOR GLOBAL HEALTHCARE EMBC'20》
    • 2020年
    • 会议

    Microwave ablation has become a common treatment method for liver cancers. Unfortunately, microwave ablation success is correlated with clinician's ability for proper electrode placement and assess ablative margins, requiring accurate imaging of liver tumors and ablated zones. Conventionally, ultrasound and computed tomography are utilized for this purpose, yet both have their respective drawbacks. As an alternate approach, electrode displacement elastography offers promise but is still plagued by decorrelation artifacts reducing lesion depiction and visualization. A recent filtering method, namely dictionary representation, has improved contrast-to-noise ratios without reducing delineation contrast. As a supplement to this recent work, this paper evaluates adaptations on this initial dictionary-learning algorithm and applies them to an EDE phantom and 15 in-vivo patient datasets. Two new adaptations of dictionary representations were evaluated, namely a combined dictionary and magnitude-based dictionary representation. When comparing numerical results, the combined dictionary representation algorithm outperforms the previous developed dictionary representation in signal-to- noise (1.54 dB) and contrast-to-noise (0.67 dB) ratios, while a magnitude dictionary representation produces higher noise levels, but improves visualized strain tensor resolution.

    ...
  • 2.Temporal Correlations between Cervical Smooth Muscle Force Generation and Acoustic Backscatter Coefficient Parameters

    • 关键词:
    • Backscattering;Electrostatic devices;Correlation methods;Backscatter coefficients;Pearson correlation coefficients;Quantitative ultrasounds;Scatterer size;Smooth muscle functions;Smooth muscles;Temporal correlations;Uterine cervix
    • Santoso, Andrew;Vink, Joy;Gallos, George;Feltovich, Helen;Hall, Timothy
    • 《2018 IEEE International Ultrasonics Symposium, IUS 2018》
    • 2018年
    • October 22, 2018 - October 25, 2018
    • Kobe, Japan
    • 会议

    In this work, we extend our novel understanding of smooth muscle in the uterine cervix by assessing if Quantitative Ultrasound (QUS)backscatter parameters correlate with muscle force generation using Pearson correlation coefficients r. Specific parameters investigated were the effective scatterer diameter (ESD)and average backscatter coefficient (ABSC), which quantify the frequency dependence and magnitude of backscatter, respectively. It was determined that correlations between force and ESD were substantial (median r=0.88)in time windows shortly after (5 minutes)administration of a contractile agent. This work provides evidence that QUS backscatter parameters may serve as a non-invasive biomarker of the cervical smooth muscle function. © 2018 IEEE.

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