无创血管弹性与矢量血流融合成像的方法研究
项目来源
国(略)研(略)((略)D(略)
项目主持人
罗(略)
项目受资助机构
清(略)
立项年度
2(略)
立项时间
未(略)
项目编号
2(略) YFC0102201
项目级别
国(略)
研究期限
未(略) (略)
受资助金额
8(略)3(略)
学科
数(略)装(略)
学科代码
未(略)
基金类别
“数(略)装(略) ”重点专项
关键词
超(略) (略)流(略);(略)血(略) (略)l(略)s(略)d(略)a(略)g(略)b(略)d(略)o(略)m(略)n(略) (略)t(略)f(略) (略)g(略)
参与者
未(略)
参与机构
未(略)
项目标书摘要:超声(略)维血流速度信息,相(略)能够展示更精确的血(略)成为医学超声领域中(略)了结合扩展自相关算(略)测速度范围,并引入(略)了基于多普勒的矢量(略)计算机仿真和仿体实(略)
Applicati(略): Compare(略)tradition(略)ow imagin(略)ltrasonic(略)w imaging(略)e two-dim(略)formation(略)low veloc(略)ess highl(略)hemodynam(略)ristics.C(略),ultrason(略)low imagi(略)become th(略)hot topic(略)ld of med(略)ound.This(略)cribes an(略)utocorrel(略)ithm,whic(略)he range (略)le veloci(略)correlati(略)m,and int(略) least sq(略)iple to f(略)mize vect(略)ocity mea(略)e method (略)d through(略)imulation(略)om experi(略)
项目受资助省
北(略)
1.A Compressed Sensing Strategy for Synthetic Transmit Aperture Ultrasound Imaging
- 关键词:
- Compressed sensing; contrast; frame rate; resolution; synthetic transmitaperture; ultrasound imaging;HIGH-FRAME-RATE; SIGNAL RECONSTRUCTION; PRINCIPLES
- Liu, Jing;He, Qiong;Luo, Jianwen
- 《IEEE TRANSACTIONS ON MEDICAL IMAGING》
- 2017年
- 36卷
- 4期
- 期刊
A novel beamforming technique, named compressed sensing based synthetic transmit aperture (CS-STA) is proposed to speed up the acquisition of ultrasound imaging. This technique consists of three steps. First, the ultrasound transducer transmits randomly apodized plane waves for a number of times andreceives the backscattered echoes. Second, the recorded backscattered echoes are used to recover the full channel dataset of synthetic transmit aperture (STA) with a compressed sensing (CS) reconstruction algorithm. Finally, an STA image is beamformed from the recovered full STA dataset. As CS allows recovering a signal from its few linear measurements with high probability, CS-STA is capable of recovering the STA image with fewer firings (i.e., higher frame rate) and retaining the high resolution of STA. In addition, the contrast of the STA image can be improved at the same time owing to the higher energy of plane wave firing in CS-STA. Simulations demonstrate that CS-STA is capable of recovering the STA channel dataset with a smaller number of firings. The performance of CS-STA is evaluated in phantom experiments through comparisons with STA, multi-element STA, conventional focused mode and coherent plane wave imaging. The results demonstrate that, implemented with the same frame rate, CS-STA achieves higher or comparable resolution and contrast. Moreover, comparisons are conducted on the biceps brachii muscle and thyroid of a human subject, and the results demonstrate the feasibility and competitiveness of CS-STA in the in vivo conditions.
...2.无创血管弹性与矢量血流融合成像的方法研究专题报告(Technical report of the methodology study of noninvasive vascular elasticity and vector flow imaging)
- 关键词:
- 超声成像、弹性成像、脉搏波成像、Ultrasound imaging、elasticity imaging、pulse wave imaging
- 罗建文;
- 《清华大学;》
- 2019年
- 报告
脉搏波成像通过对血管壁的运动进行成像,测量血管的局部脉搏波速度(PWV),用以评价血管的局部硬度。本报告介绍了课题在脉搏波成像方法研究方面的进展,包括方法开发、参数优化、仿体实验系统搭建、序列开发与仿体实验验证。Pulse wave imaging uses high temporal resolution ultrasound imaging to map the motion of arterial wall and to quantitatively measure the regional or local pulse wave velocity(PWV),as an evaluation of arterial stiffness.This report describes the progress of this project on the methodology study of pulse wave imaging,including methodology development,parameter optimization,phantom experimental system setup,imaging sequence development and phantom experimental validation.
...3.无创血管弹性与矢量血流融合成像的方法研究验收报告(Final report of the methodology study of noninvasive vascular elasticity and vector flow imaging)
- 关键词:
- 超声成像、弹性成像、脉搏波成像、血管应变成像、矢量血流成像、Ultrasound imaging、elasticity imaging、pulse wave imaging、vascular strain imaging、vector flow imaging
- 罗建文;
- 《清华大学;》
- 2019年
- 报告
本报告总结了课题在血管弹性与矢量血流成像方法研究的结果,包括血管脉搏波成像、血管应变弹性成像与血管矢量血流成像的方法开发与验证,为这些方法在国产便携式超声诊断设备中的实现以及临床试验验证奠定了方法基础。 This report summarizes the results of the methodology study of vascular elasticity and vector flow imaging,including development and validation of vascular pulse wave imaging,vascular strain imaging and vector flow imaging.These studies lay the foundation for implementations on portable ultrasound system and clinical experimental validation of these methods
...4.Compressed Sensing Based Synthetic Transmit Aperture Imaging: Validation in a Convex Array Configuration
- 关键词:
- Mean square error;Synthetic apertures;Ultrasonic imaging;Image quality;Contrast to noise ratio;convex array;Linear transfer function;Pulse echo ultrasound;Radio-frequency datum;Root mean square errors;Synthetic transmit aperture imaging;Synthetic transmit apertures
- Liu, Jing;He, Qiong;Luo, Jianwen
- 《IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control》
- 2018年
- 65卷
- 3期
- 期刊
According to the linear acoustic theory, the channel data of a plane wave emitted by a linear array is a linear combination of the full data set of synthetic transmit aperture (STA). Combining this relationship with compressed sensing (CS), a novel CS based ultrasound beamforming strategy, named compressed sensing based synthetic transmit aperture (CS-STA), was previously proposed to increase the frame rate of ultrasound imaging without sacrificing the image quality for a linear array. In this paper, assuming linear transfer function of a pulse-echo ultrasound system, we derived and applied the theory of CS-STA for a slightly curved array and validated CS-STA in a convex array configuration. Computer simulations demonstrated that, in the convex array configuration, the normalized root-mean-square error between the beamformed radio-frequency data of CS-STA and STA was smaller than 1% while CS-STA achieved four-fold higher frame rate than STA. In addition, CS-STA was capable of achieving good image quality at depths over 100 mm. It was validated in phantom experiments by comparing CS-STA with STA, multielement synthetic transmit aperture (ME-STA), and the conventional focused method (focal depth = 110 mm). The experimental results showed that STA and CS-STA performed better than ME-STA and the focused method at small depths. At the depth of 110 mm, CS-STA, ME-STA, and the focused methods improved the contrast and contrast-to-noise ratio of STA. The improvements in CS-STA are higher than those in ME-STA but lower than those in the focused mode. These results can also be observed qualitatively in the in vivo experiments on the liver of a healthy male volunteer. The CS-STA method is thus proved to increase the frame rate and achieve high image quality at full depth in the convex array configuration. © 1986-2012 IEEE.
...5.A Systematic Investigation of Lateral Estimation Using Various Interpolation Approaches in Conventional Ultrasound Imaging
- 关键词:
- Cross-correlation function (CCF); elastography; lateral displacement;lateral interpolation; lateral strain; line density; RF signals;NONINVASIVE VASCULAR ELASTOGRAPHY; IN-VIVO; MYOCARDIAL ELASTOGRAPHY;STRAIN ESTIMATION; SPECKLE-TRACKING; PRELIMINARY EXPERIENCE;PERFORMANCE; DISPLACEMENT; VALIDATION; ELASTICITY
- Liu, Zhi;Huang, Chengwu;Luo, Jianwen
- 《IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL》
- 2017年
- 64卷
- 8期
- 期刊
Accurate lateral displacement and strain estimation is critical for some applications of elasticity imaging. Typically, motion estimation in the lateral direction is challenging because of low sampling frequency and lack of phase information in conventional ultrasound imaging. Several approaches have been proposed to improve the performance of lateral estimation, such as lateral interpolation on the radio frequency (RF) signals (Interp_RF), lateral interpolation on the cross-correlation function (Interp_CCF), and lateral interpolation on both the RF signals and cross-correlation function (Interp_Both). In this paper, the estimation performances of the above-mentioned three approaches are compared systematically in simulations and phantom experiments. In the simulations, the root-mean-square error (RMSE) of axial/lateral displacement and strain is utilized to assess the accuracy of motion estimation. In the phantom experiments, the displacement quality metric (DQM), defined as the normalized cross-correlation between the motion-compensated reference frame and the comparison frame, and the contrast-to-noise ratio (CNR) of axial/lateral strain are used as the evaluation criteria. The results show that the three approaches have similar performance in axial estimation. For lateral estimation, if the line density of ultrasound imaging is relatively high (i.e., >4.2 lines/mm), Interp_CCF is comparable to Interp_Both, and Interp_RF performs the worst. However, if the line density is relatively low (i.e., <2.8 lines/mm), Interp_Both performs the best as indicated by the lowest RMSEs or highest DQMs and CNRs in lateral estimation. The trend is consistent at different window sizes, applied strains, and sonographic signal-to-noise ratios (>20 dB). Besides, Interp_Both with a small interpolation factor (e.g., 3-5) is found to obtain the best tradeoff between the estimation accuracy and the computational cost, and thus is suggested for lateral motion estimation in the case of a low line density (i.e., <2.8 lines/mm).
...6.NOVEL METHOD FOR VESSEL CROSS-SECTIONAL SHEAR WAVE IMAGING
- 关键词:
- Circumferential; Cross section; Directional filter; Guided wave; Radialmotion; Shear wave imaging; Vessel elastography;ULTRASOUND ELASTOGRAPHY; IN-VIVO; MECHANICAL-PROPERTIES; ARTERIALSTIFFNESS; TISSUE ELASTICITY; RADIATION FORCE; CAROTID-ARTERY;VALIDATION
- He, Qiong;Li, Guo-Yang;Lee, Fu-Feng;Zhang, Qihao;Cao, Yanping;Luo, Jianwen
- 《ULTRASOUND IN MEDICINE AND BIOLOGY》
- 2017年
- 43卷
- 7期
- 期刊
Many studies have investigated the applications of shear wave imaging (SWI) to vascular elastography, mainly on the longitudinal section of vessels. It is important to investigate SWI in the arterial cross section when evaluating anisotropy of the vessel wall or complete plaque composition. Here, we proposed a novel method based on the coordinate transformation and directional filter in the polar coordinate system to achieve vessel cross-sectional shear wave imaging. In particular, ultrasound radiofrequency data were transformed from the Cartesian to the polar coordinate system; the radial displacements were then estimated directly. Directional filtering was performed along the circumferential direction to filter out the reflected waves. The feasibility of the proposed vessel cross-sectional shear wave imaging method was investigated through phantom experiments and ex vivo and in vivo studies. Our results indicated that the dispersion relation of the shear wave (i.e., the guided circumferential wave) within the vessel can be measured via the present method, and the elastic modulus of the vessel can be determined. (E-mail: luo_jianwen@tsinghua.edu.cn) (C) 2017 World Federation for Ultrasound in Medicine & Biology.
...7.Non-Invasive Identification of Vulnerable Atherosclerotic Plaques Using Texture Analysis in Ultrasound Carotid Elastography: An In Vivo Feasibility Study Validated by Magnetic Resonance Imaging
- 关键词:
- Angular distribution;Classification (of information);Resonance;Deformation;Magnetism;Medical imaging;Strain rate;Ultrasonic applications;Atherosclerotic plaque;Composition measurements;Deformation distributions;Elastography;Gray level co-occurrence matrix;Receiver operating characteristic curves;Texture analysis;Vulnerability
- Huang, Chengwu;He, Qiong;Huang, Manwei;Huang, Lingyun;Zhao, Xihai;Yuan, Chun;Luo, Jianwen
- 《Ultrasound in Medicine and Biology》
- 2017年
- 43卷
- 4期
- 期刊
The aims of this study were to quantify the textural information of strain rate images in ultrasound carotid elastography and evaluate the feasibility of using the textural features in discriminating stable and vulnerable plaques with magnetic resonance imaging as an in vivo reference. Ultrasound radiofrequency data were acquired in 80 carotid plaques from 52 patients, mainly in the longitudinal imaging view, and axial strain rate images were estimated with an ultrasound carotid elastography technique based on an optical flow algorithm. Four textural features of strain rate images—contrast, homogeneity, correlation and angular second moment—were derived based on the gray-level co-occurrence matrix in plaque regions to quantify the deformation distribution pattern. Conventional elastographic indices based on the magnitude of the absolute strain rate, such as the maximum, mean, median, standard deviation and 99th percentile of the axial strain rate, were also obtained for comparison. Composition measurement with magnetic resonance imaging identified 30 plaques as vulnerable and the other 50 as stable. The four textural features, as well as the magnitude of strain rate images, significantly differed between the two groups of plaques. The best performing features for plaque classification were found to be the contrast and 99th percentile of the absolute strain rate, with a comparative area under the receiver operating characteristic curve of 0.81; a slightly higher maximum accuracy of plaque classification can be achieved by the textural feature of contrast (83.8% vs. 81.3%). The results indicate that the use of texture analysis in plaque classification is feasible and that larger local deformations and higher level of complexity in deformation patterns (associated with the elastic or stiffness heterogeneity of plaque tissues) are more likely to occur in vulnerable plaques. © 2016 World Federation for Ultrasound in Medicine & Biology
...8.Coded excitation for diverging wave cardiac imaging: a feasibility study
- 关键词:
- diverging wave; code excitation; chirp; golay; ultrasound; cardiacimaging;MEDICAL ULTRASOUND; PLANE-WAVE; IN-VIVO; SIGNALS; ARRAY; PENETRATION;BENEFITS; SYSTEM
- Zhao, Feifei;Tong, Ling;He, Qiong;Luo, Jianwen
- 《PHYSICS IN MEDICINE AND BIOLOGY》
- 2017年
- 62卷
- 4期
- 期刊
Diverging wave (DW) based cardiac imaging has gained increasing interest in recent years given its capacity to achieve ultrahigh frame rate. However, the signal-to-noise ratio (SNR), contrast, and penetration depth of the resulting B-mode images are typically low as DWs spread energy over a large region. Coded excitation is known to be capable of increasing the SNR and penetration for ultrasound imaging. The aim of this study was therefore to test the feasibility of applying coded excitation in DW imaging to improve the corresponding SNR, contrast and penetration depth. To this end, two types of codes, i.e. a linear frequency modulated chirp code and a set of complementary Golay codes were tested in three different DW imaging schemes, i. e. 1 angle DW transmit without compounding, 3 and 5 angles DW transmits with coherent compounding. The performances (SNR, contrast ratio (CR), contrast-to-noise ratio (CNR), and penetration) of different imaging schemes were investigated by means of simulations and in vitro experiments. As for benchmark, corresponding DW imaging schemes with regular pulsed excitation as well as the conventional focused imaging scheme were also included. The results showed that the SNR was improved by about 10 dB using coded excitation while the penetration depth was increased by 2.5 cm and 1.8 cm using chirp code and Golay codes, respectively. The CNR and CR gains varied with the depth for different DW schemes using coded excitations. Specifically, for non-compounded DW imaging schemes, the gain in the CR was about 5 dB and 3 dB while the gain in the CNR was about 4.5 dB and 3.5 dB at larger depths using chirp code and Golay codes, respectively. For compounded imaging schemes, using coded excitation, the gain in the penetration and contrast were relatively smaller compared to non-compounded ones. Overall, these findings indicated the feasibility of coded excitation in improving the image quality of DW imaging. Preliminary in vivo cardiac images of a healthy volunteer were presented finally, and higher SNR and deeper penetration depth can be achieved by coded schemes.
...9.Performance optimization of lateral displacement estimation with spatial angular compounding
- 关键词:
- Medical imaging;Strain;Angular compounding;Displacement;Elastography;Lateral displacements;Plane wave
- He, Qiong;Tong, Ling;Huang, Lingyun;Liu, Jing;Chen, Yinran;Luo, Jianwen
- 《Ultrasonics》
- 2017年
- 73卷
- 期
- 期刊
Elastography provides tissue mechanical information to differentiate normal and disease states. Nowadays, axial displacement and strain are usually estimated in clinical practice whereas lateral estimation is rarely used given that its accuracy is typically one order of magnitude worse than that of axial estimation. To improve the performance of lateral estimation, spatial angular compounding of multiple axial displacements along ultrasound beams transmitting in different steering angles was previously proposed. However, few studies have been conducted to evaluate the influence of key factors such as grating lobe noise (GLN), the number of steering angles (NSA) and maximum steering angle (MSA) in terms of performance optimization. The aim of this study was thus to investigate the effects of these factors through both computer simulations and phantom experiments. Only lateral rigid motion was considered in this study to separate its effects from those of axial and lateral strains on lateral displacement estimation. The performance as indicated by the root mean square error (RMSE) and standard deviation (SD) of the estimated lateral displacements validates the capability of spatial angular compounding in improving the performance of lateral estimation. It is necessary to filter the GLN for better estimation, and better performance is associated with a larger NSA and bigger MSA in both simulations and experiments, which is in agreement with the theoretical analysis. As indicated by the RMSE and SD, two steering angles with a larger steering angle are recommended. These results could provide insights into the performance optimization of lateral displacement estimation with spatial angular compounding. © 2016 Elsevier B.V.
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