In···ce···la···et···il···-r···st··· S···hy···oc··· a···us···RS···pe···st··· w···in···cr···ag···in···es···mu···ar···si···le···ng··· r···rr··· i···ct···s.···is···rs···en···pr···ri···ar···s ···m ··· m···bo··· d···an··· w···h ···in···es···sc···ib···ty··· a···mi···bi···, ··· f··· i···ca···it···o ···gg···ox···ti···st···s-···ia··· m···op···e ···ag···In···is···ud···wa···-s···bl···ol···ac···ca···n ···s ···CD···sy···es···d ··· h···ot···ma···ar···iz···on···d ···yc···en···io···he···e ···+ ··· C··· t···ug···ur···e ···ct···al···ou···to···rm···ab···bi···al··· c···le···, ···re···yi···in···eg···ab···na···ot···ap···e ···ta···te···nd···fi···nt···hi···io···f ···ra···lu··· M··· w···in···cr···ag··· F···t,···e ···ri···tr···ur···f ··· F···s ···bl···sp···fi···in···g ···fo···e ···ep···s ···ma···ph···s,···ci···at··· c···ul···in···na···at···. ···on···Cu···di···pt···he···w-···ab···c ···te··· i···ac···ul···MR···by···te···ri···wi···am··· a··· a···en···y ···ab···sm···nd···ng···cu···pt···s-···e ···te···id···ef···t ··· c···ri···in···ce···la···ac···ia···on···re···y,···2+···le···te···xi···iv···tr···-i···ce···am··· i···ac···ha···, ···to···g ··· a···va···g ···ir···ag···ti···nd···ct···ci··· f···ti···. ···th···or···re···ti···mo···or··· w··· a···cr···ag···nt···el···ar···ct···al···de···n ···ro···d ···A ···lu···es···ce···ag··· i···iv···em···tr···d ··· d···mi···nt···ct···al···oc··· o···he···s.···ll···iv···, ···s ···dy···es···s ···in···at··· s···te···wh···by···te···ol···e ···et···ic···CD···na··· m···op···e-···ge··· d···ve··· c···op···is···ke···ct···ci··· a···vi··· a···im···ol···ca···es···, ···er··· a···mp···en···e ···ro··· t···ra···at···nt···el···ar···SA·

Mu···-n···le···N)···ll···ra···e ···pr···in···na···s ···h-···ci···n ···ri···io···f ···pl···ti···e ··· o···n ···el···hr···h ···ch···ou···ep···ti···of···te···en···s ···in···wi···n ···ha··· s···tr···, ···er··· a···om···ng···lu···n ··· e···ci··· c···tr··· g···ra···n.···we···, ···ll···es···ma··· i···ud··· n···le···ti···in···fe···ce···d ···on···te···ge···tr···fi···it···he···ri···ng···ym···ri···tr···ur···wi···he···og···ou···at···al···Th···st··· p···os···a ···ti···zz···co···bo···iv···nd···te···ti···pr···in···at···MN···PP···la···ng···ra···y ···t ···eg···es···tr···ay···re···ti···ni···wi···ad···iv···od···wi···in···o ···im··· t···fa···ca···n ···co···ex···te···en···s ···su··· B···ri···ng···o ···ha··· v···ul···mo···s ···h ···ti··· i···rf···s,···-C··· p···er··· t···ef···ie··· a···nt···s ···co···bo···iv···ri···ng···r ···me···c ···io··· i···ov··· p···ti···ef···ie··· b···2.···an···3.··· r···ec···el···co···re···it···in···-n···le···in···g.···rt···mo··· M···AP···da···ve···re···at···pr···in···tr···gi···fo···eg···s ···h ···ni···an···oz··· s··· d···er···es···se···n ··· r···lo···an···ri···ng···ra···er···Du···g ··· f···ic···on··· s···-d···er···ia··· s···fo···, ··· p···os···pa···ef···ti···y ···pr···es···ge···te···l ···ck··· s···l-···le···af···ds···es···in···n ···3.···im···ve···t ···po···di···si···de···e ···at··· t···on···ti···l ···la···at··· p···ti··· F···ll···su···ss··· f···ic···on··· a···te···en···s ···bi···ep···bi···ry···de···em···tr···s ···ev···io···f ···4%··· c···ic···fe···re···me···on···ro···es··· s···if···ti···, ···fi···ng···-C···'s···fe···ve···s ···en···ci···bo···pr···in···re···io···nd···me···on···re···du···il··· f···co···ex···ym···ri···tr···ur···

BA···RO···: ···ol···us···ne···af···g ···co···de··· a···go···st···ar···in···e ···eo··· r···e ···me···ti···te···iq···. ···si···on··· g···ti···us···gr···s ···ac··· t···de···lo···si··· w···ou··· s···ra···do··· s···. ···er···st···es···ve···ve···d ··· s···sf···or···ho···te···pe···rm···e ···th···le···in···iv···od···ed···ch···ue···ut··· i···rm···on··· a···la··· o···ta···it···f ···eo··· r···e ···on···uc··· b···n ···u ···ay···af···g ··· i···an···er···ma··· a···r ···lu··· l···in···n ···id···rm···ll···up···hi···tu···is··· r···os···ti···y ···lu··· t···ra···gr···ic···d ···ie···re···te···ut···es···RO··· o··· m···fi···on··· g···ti···te···iq···an···he···bs···en···mp···ta···n ···an···io···ax···a ···ng··· s··· g···ts···th··· a···co···bo···ha···st··· r···on···ME···DS··· t···l ···83···ti···s ···tr···te···19···en···ou···ef···en···si···, ··· 1···im···nt···er···la··· i···nt···or···xi···. ···pa···nt···ec···ed··· s··· o···y ···ft··· u···g ···na··· g···ts···d ···pa···nt···ec···ed··· s··· o···y ···ft··· u···g ···di···ar···mp···is···af··· A···ol···ri··· h···ht···d ···ti···el···wi···s ···e ···es··· u···g ···e-···m ···pu··· t···gr···y ···CT···ri···gr···in···nd··· f··· s···eq···t ···e ···nt···Cl···ca···ar···te···an···RO···we···ev···at···wi···a ···ua···na··· s···e ···S)···ri···th···ol···-u···Ap···xi···el···mo···s ···er···la···ra···ng···en··· i···an···we···pl···d ···lo··· b···ix···pr···he··· r···bi···at···. ···la···su···va···nd···cc··· r···s ···e ···es··· w··· a···an···ll···up··· 4···0m···hs···RE···TS···he···ri···ta···on···es···ti···at···rv···l ···el···te···-y··· o···us···lo···ng··· i···it···ro···(1···%±···9%···as···we···ha···ha···f ···si···(3···%±···0%···ro···(P···04···No···he···ig···ic··· d···er···e ···ar···g ···e ···or···on···s ···nd···he···ti··· r···rt···pa···sc···s ···7d··· a···r ···ge···of··· s··· g···p ···43···17···as···we···ha···ha···f ···si···gr··· (···7±···8,···0.···. ···im···nt···ss···s ···er···. ··· i···an···uc···s ···es···re···.3···in···-s··· g···p ··· 9···6%··· e···it···ro···; ···CL···ON···Wi···n ··· l···ta···ns··· t···pr···nt···tr···ec···e ···dy···he···nd···s ···ge···th···in···tu···la···ra···ng···y ···a ···mi···g ···ro··· f···re···st···ti···th···nt···or···xi···ry···ve···r ···ge···d ···il···ti···su···qu··· i···an···la···en···Th··· p···im···ry···su··· a···hy···he···-g···ra···g ··· w···an···ur···r ···id···on···ro··· p···pe···ve···on···er···nv···ig···on··· T···L ···IS···TI··· T··· s···y ··· r···os···ti···y ···is···ed··· C···es···li···al···ia···eg···ry···eg···ra···n ···be···Ch···R2···08···4,···gi···at··· d···: ···4-···08···© ···6.···e ···ho···).

Me···cr···te···el···n ···lM···hy···ge···ha···be···we···re···ni··· a··· w···ly···ed···tu··· p···me···or···of···ic···on···ue··· t···ad···ab···ty···r ···ti··· c···sl···in···ch···s,···si···le···oc···at···li···an···io···ra···il···, ··· e··· o···he···al···nc···na···at···. ···h ···ar···o ···bi···in···g,···we···, ···MA···s ···wn···sa···fa···ry···in···g ···bi···y ··· a···ra···du···o ···w ···-g···tr···it···, ···op···al···ch···ca···tr···th···nd···ri···te···ra···e ···tr···fo···ri···ng···e ···ei···ev···pe···n ···ov···ve···al···os···nk···e ···lo···l ···s ···po··· o···el···ss···le···el···na···ph···s ···h ···% ···f-···li···ef···ie···, ···ch···tp···or···he···ad···on···Ge··· p···me··· i··· i···er···of···ha···d ···nt···li···an···id···ty···ro···r ···nt··· t···er···re···ng···ad···ta··· m···an···l ···en··· r···in···ro···ra···an···gu···.8···Pa··· c···ia···na···ue···.4···Pa···nd···pr···d ···-f···ti···li···s ···de···d ···th···le···ed···dr···il···ty···as···ra···er···fi···nc···nd···ol···ed···ug···le··· p···il···Mo···ve···th···ra···at··· d···gn··· G···A ···s ···oc··· f···fo···3D···in···g ···es···ch··· d···ct···lt···nk···it···, ···ed··· p···ti··· b···al···al···ed···-s··· p···ti···di···tl···t ··· b···di···wo··· s···s ··· t···he···ts···di···he···ta··· e···ca···an···et···k ···bi···y ···co···id···ge··· I···en···l,···r ···os···ct···d ···MA···ll···al···ks···es··· a···tt···re···ce···t ··· t···tr···ti···l ···MA···ly···ic···ks··· 3···io···nt···, ···ch···ta···sh···a ···nd···on···r ···ch···-b···id···ra···at···s ···3D···in···g ···hn···es···wa··· m··· p···ti··· c···ic···ap···ca···ns·

Cr···of···al···sc··· a···es···ti···co···ne··· o···he···el···l ···cu··· s···em···at···nt···ut···o ···or···t ···si···gi··· p···es···. ···er···ra··· c···in···e ···ni···ci···vo···et··· m···le···ss···ML···wh··· i···ir···us··· r···ne···io···ca···s ···ia···us···ar···fo···ti···an···un···on···di···il···, ··· l···s ···ps···os···al···ns···en··· s··· a···so···io···nd···pr···io···Co···nt···al···er···es···vo···ng···sc···fl···tr···po···io···r ···ol···us···ss···gr···in···ch···e ···ph···gi··· r···ir···t ··· i···fe···ve··· r···or··· m···le···nc···n,···su···ng··· d···r ···e ···ur···nd···ns··· d···ci···In···is···ud···we···cc···fu··· c···tr···ed···bi···me···al···en···ee··· m···le···ss···th···in···ra··· m···ib···al···me··· e···ct··· i···rv···on···nd···oo···er···io···o ···mo···mu···-t···ue···ge···at··· i···he···ss···r ···a ···vi··· e···li···fu···io··· r···ne···io···Us··· l···t-···tr···ed···cr···tt···in···ec···lo··· w···on···uc··· m···re···sc···fi···s ···h ···en··· a···nm··· a···es···li···d ···eu···us···ar···-c···ur···ys··· f···in···tr···eu···us···ar···nc···n ···on···uc···n.···rt···mo··· w···es···ed···d ···ri···ed···va···la···et···k ···uc···e ···pr···te···ss···va···la···at··· u···g ···ro··· a···he···hi··· f···as···bl··· t···co···si···en···ee··· t···ue···si···th···te···ol···, ··· s···e ··· d···ns··· o···he···ns···ct···en···y ··· b···us···iz···to···dr··· v···ou···us··· d···ct···en···in···nd···du···ze···ep···. ···s ···dy···fe···a ···mi···g ···el···ra···y ··· t···ue···ge···at··· t··· b···ks···ro··· t···cu···nt···al···ge···n ··· t···tm··· o···ra···fa···l ···.[···PH···].

Pe···he··· n···e ···ur··· a···a ···va···t ···ba···ss···th···ha···ar···ed···ea···on···n.···th···h ···og···ts···ma···th···re···re···li···al···pr···h ···re···r,···ei···ff···cy··· h···er···by···ct··· l··· d···r ···rc···. ··· e···ge··· o···er···gu···nc···on···ts··· n···l ···su···ng···er··· t···s ···er··· p···is··· a···rn···ve···ra···y.···is···vi···ai···to···te···et···rv···ui···ce···nd···s ··· t···r ···me···al···ti···fr···bo···cl···ca···nd···bo···or···er···ct···s.··· e···nc···om···he···on··· c···ic···si···ti···, ···s ···ic···pr···de··· c···re···si···an···si···f ··· c···ic···ef···ac···f ···ve···nd···s ···ro··· b···he···it···St···s ···d ··· D··· A···ni···at···. ···pr···se···ha···he···it··· s···mo···s ···t-···ns···nt···on··· a···it···l ···do···er··· f···ev···at··· t···r ···ic···. ···it···al··· t··· s···y ···du··· a···st···ti···is···si···on···e ···ea··· p···re···of···bo···or···on···ts···oc···ng··· b···at···al···nd···d-···st···eg··· a···iv···l ···to···fo···er···re···er···on···s ···po···d ···th···it···tu···an···si···Th···li···al···nd··· m···ri··· a···pr···ec···e ···im···ma···ia···ar···ho···gh···di···ss··· T···ad···n ···at···es···og···er···th···ei···is···ct···st···es···d ···en···ls···e ···pl···na···ed···as···on···e ···ve···al···io··· t···de···op···t ···h ··· m···fa···ri···st···eg···or···e ···me···al···ti···of···rv···ui···ce···nd···s ··· e···si···d.···e ···ti··· c···lu···n ···mo···g ···me···al···ti···is···mm···ze···s ···lo··· 1···he···ti···at··· o···io···er···s ···th···un···en··· m···s;··· T···ph···d ···li···io···f ···it···al···ra···ie···s ··· e···as···d ···ec···n;··· T···ad···iv···an···ct···ng···ch···ue···re···e ···es···y ···ls···s ···es···, ··· f···in···of···is···se···h ···vi···ac···mi···nd···in···l ···ct···on··· w··· v···ab···in···ht···ha···ay···ci···at···ut··· c···er···li···io···nd···or···f ···ve···id···e ···du···. ···02···he···th···

Th···es···in···nd···nu···tu···g ···mi···/n···sc··· t···s ··· d···ve··· d···no···c,···d ···ra···ti···re···se···al···r ···ir···lt···al···nt···at··· i···he···ec···on···di···e ···ld···on···ti···l ···ee···me···on···(3···pr···in···pp···ch···ar···ot···it···e ··· s··· k··· o···oo···du···o ··· a···ra···li···at···. ···ti···to···ol···ri···io···MP···ba··· m···o/···om···fa···ri···is···no···nt···, ···h-···ci···n ···di···te···ol··· t··· h···be···wi···y ···d ···th···ic···na···fi··· i··· p···is··· t··· f···mi···/n···sc··· r···te···re···io···ed···ne···n ···s ···ic···th···un···en···s ···MP···as···te···ol··· a···th···eq···ed···te···ls··· p···is··· m···ci···ar···ve···ew··· T···bi···di··· a···ic···on···n ···io···sc···ri···ar···he···um···iz···an···at···ri··· a···el···ry···st···, ···ro···su···od···ng···ur···y,···d ···gn···s.···na···, ··· e···ti···ch···en··· a···fu···e ···sp···iv···on···P-···ed···cr···an···nu···tu···g ··· p···is··· m···ci···ar···is···se···fo···in···n ···er··· d···gn···ro···s ···im···ti··· a···pr···ic···ap···ca···ns··· o···co···it···ur···t ···it···on···© ···4 ··· A···OR·

Em···de···nk···it··· (···) ···an···er···g ···pr···in···ec···qu···ha···ab···at···co···ex··· s···ct···s ···m ···io···bi···te···l ···s ··· i···im···d ···a ···nt··· s···d ···10···-1···e ···su···ti··· r···lo···al···op···ie···f ···ti···at···om···te···ie···st···s ···id···he···se···s ···ui···at··· I···hi···or···a ···ti···-h···og···in···ac···e ···te···o ···ig···dv···ed···th···it···nh···ed···el···tr··· a···ex···de···hi···ro··· r···on···ti···fo···ea···in···ig···pe···EI···s ···el···d.··· t··· s···em···he···te···ti··· b···ee···ar···le···di···e ··· t···e ···re···ta···e ···ym···c ···ro···s ···bl···he···su···ng···no···po···es··· d···ns···te···ff···nt···eo···ic···be···io··· A···rd···ly···he···te···ti···mo···s ··· t···na···om···it···ar···st···is···, ···ch···e ···se···nt···va···at···by···cr···al···he···gi··· m···ur···nt···nd···va···d ···ro···uc···e ···ra···ri···io···ec···qu··· F···me···fo···ti···me···ni··· i···he···rt···e-···ro··· i···ra···ve···th···re···mp···en···el···nv···ig···d ···hi···pr···in···pe···. ···de···st···e ··· e···ct···ne···of···e ···po··· h···-s···d ··· m···od···n ···to···-s··· h···n ···ne···on···uc···s ···ce···ul···pr···ed··· 1···ms··· w···h ···y ···es···. ···s ···k ···ak···he···in···g ···ed···rr··· i···ur···t ··· a···pr···ls···e ···im···pr···in···pe···by··· l···t ···ti···, ···vi···g ···ef···ie···an···ro···in···ol···on···r ···an···co···ru···on··· t···fu···e.···20···Th···ut···(s···Ad···ce···ci···e ···li···d ···Wi···‐V···Gm···

Re···er···on···d ···on···uc···n ···bo···ti···e ···al···s ···ha···ng···or···in···an···ue··· t···un···ta···y ···bo···re···r ···er···s ···te··· o···on···er···nd···fi···nt···fe··· o···st···la···. ···e,··· p···os··· n···l ···at··· c···in··· b···di···e,··· a···hy···te···ve···ug···d ···op···ic··· t···yn···is···al···pr···te···e ···li···of···ne···fe···. ···se···d ···ou···en···pi···lo···d ···ne···m ···ic··· n···pa···cl···we···pr···re···nd···li···ed···r ···ir···os···ty···he···no···ti···s ···e ···ic···tl···ak···up··· p···st···la··· a···un···rm···di···ib···d ···un···he···cl···. ···er···te···li···io···nt···el··· t···na···ys··· i···eg···ed··· l···so···, ··· t···ef···t ···pr···ti···os···ge··· d···er···ia···n ···re···ct···by···e ···ti···us···le··· o···en···pi··· s···co···nd···gn···um···ns···ur···su··· c···rl···va···te···ha···he···no···we···ik···ag···iu···il···te···li···in···en···pi···te··· t···em···ap···pr···ef···he···e ···en···ti···in···eo···ob···ts···nd···ti···th···it···gh···e ···ot···ia···pp···ch··· g···in···on···ep··· i···li···al···pl···ti···. ···ph···ab···ac···[F···re···t ···il···e:···e ···lt···.]···20··· Z···ia···Un···rs··· P···s.

Th···ma···in···ti···s ···ri···e ···uc···e ···bl···vi··· f···ti··· s··· a···ut···nt···so···io···mi···bi···de···se···nd···rr··· p···ec···n,···t ···li···in···ts···mp···it···n ···ro···ma··· a···bs···ti···ch···en··· W···ng···er···a ···ee···me···on···bi···in··· i···st···l ···el···at···ng···om···ti···ir···ar···ld···nd···na··· s···r ···es···is···bu···n ···re···it···te···ti···ph···ol···. ···il···nt···so···d ···ed··· b···ri···ng···pr···h ···bl···hi···fi···it···ab···at··· o···hi···al···, ···ti···us···ru···re···ha···ha··· p···io···ic···y ···ev··· f··· m···oe···ro···nt···ss···ia···or···it···ia···ev···pm···. ···se···ea···tr··· p···er···re···at···ti··· j···ti···, ···re···y ···iv···, ··· t···sp···er···pr···io···dr···ng···gi···sp···fi···pi···li···sp···al···ti···in···ba···er··· a···rp···e ···no···es···oc···ur···it···ro···ti···ac···ac···us···an···um···ti···ed···ca···ed···mu···re···ns···an···od···te···pi···li···fu···io···hr···h ···ti···y ···ti··· c···ni···io···Re···na···lo···if···en··· g···rn···th···ra···or···f ···ri··· a···dr···pr···s ··· t···sc···ul···an···ar···ll···r ···hw···. ···nt···ti···as···sm··· o···ru···bs···ti···de···st···ed···ro···in···tr···n ···o ···re···io···va···at··· p···io···ic···re···an··· B···ni···ng···ru···ra···me···ni···, ··· f···ti···l ···pl···ty···hi···la···rm···va···s ···es···al···de···fo···tu···ng···ys···og···ho···mi···be···te···ti···, ··· d··· t···sp···.