项目来源
国家重点研发计划(NKRD)
项目主持人
沈群东
项目受资助机构
南京大学
项目编号
2017YFA0701301
立项年度
2017
立项时间
未公开
研究期限
未知 / 未知
项目级别
国家级
受资助金额
692.00万元
学科
变革性技术关键科学问题
学科代码
未公开
基金类别
未公开
关键词
人工视网膜 ; 视觉响应材料 ; 感光分子 ; 铁电高分子 ; 眼部植入 ; Artificial Retina ; Visually Responsive Materials ; Light-Sensitive Molecules ; Ferroelectric Polymers ; Ocular Implant
参与者
蒋锡群；初宝进；冯福德；叶德举
参与机构
中国科学技术大学
项目标书摘要：本研究应用新型视觉响应材料替代天然视网膜中的感光细胞，将光信号转导成神经信号，构筑一类集成光感应和神经信号传递功能、具有生物融合性质的人工视网膜；可将其应用于替代、修复视觉系统的功能，提高视网膜的分辨率，拓展视网膜可识别的光谱范围，甚至实现超视觉功能。我们研究了感光材料—铁电高分子能量耦合机制，结果表明感光材料光热效应和铁电高分子材料热释电效应的高效耦合有利于高效率的光电转换。人工视网膜能实现对可见和近红外光的感应，输出电压达到几百毫伏，输出的电信号取决于光刺激的强度。我们合成了规整型共轭聚合物感光材料，与电子受体富勒烯衍生物(PCBM)、铁电高分子材料复合，制备成光电转换器件，在可见光区表现出良好的光电响应，开路电压达180 mV。光照条件下，光电响应薄膜与神经细胞之间存在信息交流，周期性点阵结构薄膜刺激神经细胞的效果明显优于平面结构薄膜。仿生视网膜通过眼科手术植入大白兔、大鼠和恒河猴等眼睛中。大白兔眼部手术植入一年后，人工视网膜保持完整形态，其周围组织及血管无明显异常。大鼠眼部植入人工视网膜后，在光刺激下视觉皮层诱发电位信号显著增加，表现出避光及在较短时间内发现平台的能力。我们还研究了评估视网膜乏氧和细胞内生物分子的光学材料；探索了利用光电纳米材料刺激视网膜内的神经胶质细胞，诱导增殖甚至分化成为光感细胞进而恢复受损视网膜。
Application Abstract: The project aimed at novel visual response materials for replacing the photoreceptor cells in the natural retina.The incident light was transduced into the neural signal.The artificial retina had the functions of both light sensing and neural signal transmission,thus took the advantage of integration with biological tissues.It can be applied to replace and repair the function of the visual system,improve the resolution of the retina,expand the spectrum recognized by the retina,and even realize the supervision.We studied the energy coupling mechanism of the photosensitive materials and ferroelectric polymers;and the results showed that the efficient coupling between photothermal effect of the photosensitive materials and pyroelectric effect of the ferroelectric polymers was beneficial to the high-efficient photoelectric conversion.The artificial retina could sense both visible and near-infrared light with an output voltage of several hundred millivolts,depending on the light intensity.We synthesized regioregular conjugated polymers as photosensitive materials.They were then combined with electron acceptor PCBM and ferroelectric polymer to fabricate photoelectric devices,which showed good photoelectric response in the visible region and open-circuit voltages up to 180 mV.Under the light stimulation,there is information exchange between the photoelectric response membrane and the nerve cells.The membrane with periodic lattice structure could stimulate the nerve cells better than that with planar structure.The bionic retinas were implanted into the eyes of white rabbits,rats,and rhesus monkeys through surgery.One year after implantation,the artificial retina remained intact.There were no obvious abnormalities in the surrounding eye tissues and blood vessels.After the implantation of artificial retina in the eyes of rats,the visual evoked potential increased significantly under light stimulation;and the rats showed the ability to avoid light and find the platform in a short time.We also studied optical materials to evaluate retinal hypoxia condition and intracellular biomolecules.We explored the possibility of the photoelectric nanomaterials to induce the proliferation of the glial cells in the retina and even differentiate into photoreceptor cells,for recovery of the damaged retina.
项目受资助省
江苏省
联系人信息
沈群东：qdshen@nju.edu.cn
