项目来源
芬兰研究理事会基金(AKA)
项目主持人
未公开
项目受资助机构
Tampere University
立项年度
2021
立项时间
未公开
项目编号
34131
研究期限
未知 / 未知
项目级别
国家级
受资助金额
285556.00欧元
学科
BIOCHEMISTRY
学科代码
未公开
基金类别
Research Council of Finland-Post Doctoral Researcher
关键词
Biokemia ; biofysiikka ; silmätaudit ; ikääntyminen ; verkkokalvo ; näkö ; eye diseases ; ageing ; retina ; eyesight ; molecular biology ; biochemistry ; biomedicine
参与者
未公开
参与机构
未公开
项目标书摘要：Currently,1.3 billion people live with vision impairment,and rapidly aging population is set to suffer from age-related visual diseases.The molecular mechanisms underlying these diseases is not fully understood.A potential mechanism is the dysregulation of ion channels and the circadian clock in the retina-retinal pigment epithelium(RPE)-interface.My overall goal is to elucidate the links between ion channels and circadian clock in the RPE.This will be achieved by an interdisciplinary approach encompassing bioinformatics analysis of publicly available datasets,molecular,high resolution imaging,electrophysiological techniques together with tissue engineering and stem cell technology.The described experiments will elucidate the complex molecular interplay between ion channels and circadian clock in the retina-RPE interface.These findings are likely to advance the development of new treatments for age-related visual disorders.
Application Abstract: Currently,1.3 billion people live with vision impairment,and rapidly aging population is set to suffer from age-related visual diseases.The molecular mechanisms underlying these diseases is not fully understood.A potential mechanism is the dysregulation of ion channels and the circadian clock in the retina-retinal pigment epithelium(RPE)-interface.My overall goal is to elucidate the links between ion channels and circadian clock in the RPE.This will be achieved by an interdisciplinary approach encompassing bioinformatics analysis of publicly available datasets,molecular,high resolution imaging,electrophysiological techniques together with tissue engineering and stem cell technology.The described experiments will elucidate the complex molecular interplay between ion channels and circadian clock in the retina-RPE interface.These findings are likely to advance the development of new treatments for age-related visual disorders.
