项目来源
美国卫生和人类服务部基金(HHS)
项目主持人
SALAZAR, DESIREE LYNN
项目受资助机构
STOWERS INSTITUTE FOR MEDICAL RESEARCH
立项年度
2017
立项时间
未公开
项目编号
5R37GM057260-19
项目级别
国家级
研究期限
未知 / 未知
受资助金额
297000.00美元
学科
Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human
学科代码
未公开
基金类别
Non-SBIR/STTR RPGs
关键词
未公开
参与者
SANCHEZ ALVARADO, ALEJANDRO
参与机构
NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
项目标书摘要：The overarching goal of this project is to define a mechanistic basis for the process of animal regeneration. This project takes advantage of methodological advances and findings obtained during the last funding period to: 1) define a high temporal resolution, genome-wide, expression profile of regeneration; 2) interrogate the functions of known embryonic signaling pathways in the adult contexts of tissue regeneration and homeostasis, and to carry out a formal comparison of how the mechanisms of regeneration compare to embryogenesis; 3) uncover genes involved in the regeneration of adult organs after amputation; and 4) Initiate comparative studies of regeneration to test the universality of our findings. All three lines of investigation synergize with each other and their integration should provide us with a high-resolution set of molecular processes regulating regeneration and regenerative capacities. Thus far, this approach has led us to uncover novel animal cell biology and functions in adult contexts of known genes, and to define functions for the many conserved animal genes for which functions are still unknown. Given the high degree of evolutionary conservation that exits between planarians and vertebrates, the characterization of gene functions in planarians will advance efforts to study human stem-cell function, regeneration and wound healing, effectively advancing these frontiers of human health. RELEVANCE (See instructions): The overarching goal of this project is to define a mechanistic basis for the process of animal regeneration. Given the high degree of evolutionary conservation that exits between planarians and vertebrates, the characterization of gene functions in planarians will advance efforts to study human stem-cell function, regeneration and wound healing, effectively advancing these frontiers of human health.
