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The molecular basis of planarian regeneration

项目来源

美国卫生和人类服务部基金(HHS)

项目主持人

SALAZAR, DESIREE LYNN

项目受资助机构

STOWERS INSTITUTE FOR MEDICAL RESEARCH

项目编号

5R37GM057260-19

立项年度

2017

立项时间

未公开

研究期限

未知 / 未知

项目级别

国家级

受资助金额

297000.00美元

学科

Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

学科代码

未公开

基金类别

Non-SBIR/STTR RPGs

关键词

未公开

参与者

SANCHEZ ALVARADO, ALEJANDRO

参与机构

NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

项目标书摘要：The overarching goal of this project is to define a mechanistic basis for the process of animal regeneration. This project takes advantage of methodological advances and findings obtained during the last funding period to: 1) define a high temporal resolution, genome-wide, expression profile of regeneration; 2) interrogate the functions of known embryonic signaling pathways in the adult contexts of tissue regeneration and homeostasis, and to carry out a formal comparison of how the mechanisms of regeneration compare to embryogenesis; 3) uncover genes involved in the regeneration of adult organs after amputation; and 4) Initiate comparative studies of regeneration to test the universality of our findings. All three lines of investigation synergize with each other and their integration should provide us with a high-resolution set of molecular processes regulating regeneration and regenerative capacities. Thus far, this approach has led us to uncover novel animal cell biology and functions in adult contexts of known genes, and to define functions for the many conserved animal genes for which functions are still unknown. Given the high degree of evolutionary conservation that exits between planarians and vertebrates, the characterization of gene functions in planarians will advance efforts to study human stem-cell function, regeneration and wound healing, effectively advancing these frontiers of human health. RELEVANCE (See instructions): The overarching goal of this project is to define a mechanistic basis for the process of animal regeneration. Given the high degree of evolutionary conservation that exits between planarians and vertebrates, the characterization of gene functions in planarians will advance efforts to study human stem-cell function, regeneration and wound healing, effectively advancing these frontiers of human health.

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  • 1.Regulation of Genomic Output and(Pluri)potency in Regeneration

    • 关键词：
    • HISTONE-H3 LYSINE-4 METHYLATION; PLURIPOTENT STEM-CELLS; MULLER GLIA; METHYLTRANSFERASE ACTIVITY; TRANSCRIPTION FACTORS; H3K4 METHYLATION; RNA-SYNTHESIS; CHROMATIN; PLANARIAN; GENE
    • Duncan, Elizabeth M.;Alvarado, Alejandro Sanchez
    • 《ANNUAL REVIEW OF GENETICS, VOL 53》
    • 2019年
    • 会议

    Regeneration is a remarkable phenomenon that has been the subject of awe and bafflement for hundreds of years. Although regeneration competence is found in highly divergent organisms throughout the animal kingdom, recent advances in tools used for molecular and genomic characterization have uncovered common genes, molecular mechanisms, and genomic features in regenerating animals. In this review we focus on what is known about how genome regulation modulates cellular potency during regeneration. We discuss this regulation in the context of complex tissue regeneration in animals, from Hydra to humans, with reference to ex vivo-cultured cell models of pluripotency when appropriate. We emphasize the importance of a detailed molecular understanding of both the mechanisms that regulate genomic output and the functional assays that assess the biological relevance of such molecular characterizations.

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