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Discrete Frequency Infrared Spectroscopic Imaging for Breast Histopathology

项目来源

美国卫生和人类服务部基金(HHS)

项目主持人

KING, RANDY LEE

项目受资助机构

UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

立项年度

2017

立项时间

未公开

项目编号

5R01EB009745-08

研究期限

未知 / 未知

项目级别

国家级

受资助金额

401931.00美元

学科

Bioengineering; Biomedical Imaging; Breast Cancer; Cancer; Clinical Research; Women's Health;

学科代码

未公开

基金类别

Non-SBIR/STTR RPGs

关键词

未公开

参与者

BHARGAVA, ROHIT

参与机构

NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

项目标书摘要：DESCRIPTION: Technologies that can help make accurate, objective and automated decisions to aid the pathologist are sorely needed in clinical practice to improve accuracy and contain costs. The major goal of this project is to provide a practical imaging instrument for clinical and research use that can be operated by any trained person in pathology laboratories. The approach is based, first, on developing novel instrumentation and analytical methods for robust discrete frequency infrared (DF-IR) spectroscopic imaging. The instrument presents a departure from the current state of the art using a design inspired by recent advances in theory, newly-developed sources and advanced control algorithms. The integration of spectral analysis algorithms makes generation of molecular pathology data facile - without any dyes, stains or human supervision. The developed instrument and algorithms is tested in a clinical setting and results that will lead to clinical trials will be obtained. Finally, the approach is geared to bettr predict breast cancer course by utilizing the entire tumor microenvironment. As opposed to current practice, which largely relies only on epithelial cells, the new approach to using the entire tumor microenvironment has the potential to transform decision-making for patients and alter the standard practice of histologic assessment in research.

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  • 1.Polarimetric infrared spectroscopic imaging using quantum cascade lasers

    • 关键词：
    • Absorption spectroscopy;Polarimeters;Image enhancement;Quantum cascade lasers;Tissue;Light polarization;Tissue engineering;Degree of polarization;Infrared microscopy;Polarization factor;Polarization imaging;Spectroscopic imaging
    • Phal, Yamuna;Yeh, Kevin;Bhargava, Rohit
    • 《Advanced Chemical Microscopy for Life Science and Translational Medicine 2020》
    • 2020年
    • February 1, 2020 - February 3, 2020
    • San Francisco, CA, United states
    • 会议

    Infrared spectroscopic imaging has emerged as a powerful label-free diagnostic tool to study the molecular composition and organization in biological tissues and cells. We report infrared spectroscopic imaging using polarized light to study differential absorption of plane-polarized light by an oriented sample to detect valuable information, such as, birefringence and dichroism. For instance, the organization of collagen, specifically fiber orientation and alignment, is crucial in understanding the progression and metastasis of cancer. Recent advancements in the development of Quantum Cascade Lasers (QCL) sources have opened new avenues for high SNR measurements in the field of IR spectroscopy. In addition, QCL sources are intrinsically polarized and orientation information can be obtained at discrete frequencies with different polarization orientations, allowing much faster acquisition than a corresponding FT-IR approach. We demonstrate improved performance in terms of fast and comprehensive polarimetric image acquisition and analysis using custom-built QCL microscope and evaluate its impact on applications by analyzing the important spectral bands of surgical tissue sections. © COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.

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