项目来源

美国卫生和人类服务部基金(HHS)

项目主持人

KING, RANDY LEE

项目受资助机构

UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

项目编号

5R01EB009745-08

立项年度

2017

立项时间

未公开

项目级别

国家级

研究期限

未知 / 未知

受资助金额

401931.00美元

学科

Bioengineering; Biomedical Imaging; Breast Cancer; Cancer; Clinical Research; Women's Health;

学科代码

未公开

基金类别

Non-SBIR/STTR RPGs

关键词

未公开

参与者

BHARGAVA, ROHIT

参与机构

NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

项目标书摘要：DESCRIPTION: Technologies that can help make accurate, objective and automated decisions to aid the pathologist are sorely needed in clinical practice to improve accuracy and contain costs. The major goal of this project is to provide a practical imaging instrument for clinical and research use that can be operated by any trained person in pathology laboratories. The approach is based, first, on developing novel instrumentation and analytical methods for robust discrete frequency infrared (DF-IR) spectroscopic imaging. The instrument presents a departure from the current state of the art using a design inspired by recent advances in theory, newly-developed sources and advanced control algorithms. The integration of spectral analysis algorithms makes generation of molecular pathology data facile - without any dyes, stains or human supervision. The developed instrument and algorithms is tested in a clinical setting and results that will lead to clinical trials will be obtained. Finally, the approach is geared to bettr predict breast cancer course by utilizing the entire tumor microenvironment. As opposed to current practice, which largely relies only on epithelial cells, the new approach to using the entire tumor microenvironment has the potential to transform decision-making for patients and alter the standard practice of histologic assessment in research.