Application Abstract: Thia subject aims to resolve the major scientific frontiers of cell motility related protein machinery that how does the cytoskeleton play the orbit and structural support function,focusing on 1the regulation mechanism of the dynamic structure and function of microtubule skeleton during cell motility;2the structural mechanics,mechanism and dynamics of the specialized microtubule skeleton in the cilia;3the regulation mechanism of the cytoskeleton independent of the molecular motor in cell motility.Through the implementation of this project,we expect to apply 1 to 4 internationally leading patents with independent intellectual property rights,publish 6 to 12 research papers in mainstream academic journals in the life sciences,and cultivate an internationally advanced team.This systematic and indepth study of key protein machinery not only contributes to the understanding of the basic laws of cellular activities,but also has important theoretical significance,and helps to elucidate the pathogenesis of cell motility related diseases.It provides a theoretical basis for the discovery and development of drugs,and has important strategic significance for achieving the national goal of population health.
