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细胞骨架在细胞运动中的动态结构与功能

项目来源

国家重点研发计划(NKRD)

项目主持人

周军

项目受资助机构

山东师范大学

项目编号

2017YFA0503502

立项年度

2017

立项时间

未公开

研究期限

未知 / 未知

项目级别

国家级

受资助金额

1020.00万元

学科

蛋白质机器与生命过程调控

学科代码

未公开

基金类别

未公开

关键词

细胞骨架 ; 细胞运动 ; 动态性 ; 纤毛 ; Cytoskeleton ; cell motility ; dynamics ; cilium

参与者

谢松波

参与机构

未公开

项目标书摘要：本课题主要针对“细胞骨架如何发挥运动轨道和结构支撑功能”这一细胞运动相关蛋白质机器的重大科学前沿问题展开研究，将重点探讨微管骨架的动态结构与功能在细胞运动过程中的调控机制；阐明纤毛中特化微管骨架的结构力学、发生机制以及微管动力学的生化基础；解析独立于分子马达的细胞骨架在细胞运动中的调控机制。通过本项目的实施，我们预期将获得1-4 项具有国际领先和拥有自主知识产权的专利，在生命科学领域的主流学术刊物上发表6-12 篇研究论文，并培养一支具有国际先进水平的细胞运动研究队伍。本项目对关键蛋白质机器进行系统深入的研究，不仅有助于对细胞和生物体生命活动基本规律的认识，而且有助于阐明细胞运动相关的人类重大疾病的发病机理，为药物靶点的发现和药物的开发提供理论依据，对实现我国人口健康的国家目标具有重要的战略意义。

Application Abstract: Thia subject aims to resolve the major scientific frontiers of cell motility related protein machinery that how does the cytoskeleton play the orbit and structural support function,focusing on 1the regulation mechanism of the dynamic structure and function of microtubule skeleton during cell motility;2the structural mechanics,mechanism and dynamics of the specialized microtubule skeleton in the cilia;3the regulation mechanism of the cytoskeleton independent of the molecular motor in cell motility.Through the implementation of this project,we expect to apply 1 to 4 internationally leading patents with independent intellectual property rights,publish 6 to 12 research papers in mainstream academic journals in the life sciences,and cultivate an internationally advanced team.This systematic and indepth study of key protein machinery not only contributes to the understanding of the basic laws of cellular activities,but also has important theoretical significance,and helps to elucidate the pathogenesis of cell motility related diseases.It provides a theoretical basis for the discovery and development of drugs,and has important strategic significance for achieving the national goal of population health.

项目受资助省

山东省

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  • 2.Non-canonical function of Tat in regulating host microtubule dynamics: Implications for the pathogenesis of lentiviral infections

    • 关键词：
    • Lentivirus; Tat; Transactivation; Microtubule; Apoptosis;IMMUNODEFICIENCY-VIRUS TYPE-1; HIV-1 TAT; PROTEIN; APOPTOSIS; RNA;ACETYLATION; CONTRIBUTES; RECOGNITION; MODULATION; ACTIVATION

    Lentiviruses are a class of genetically unique retroviruses that share similar features, despite their wide variety of host species. Transactivator of transcription (Tat) proteins of lentiviruses are critical for the regulation of viral transcription and replication. Recent studies demonstrate that in addition to mediating transactivation, Tat binds to the microtubule cytoskeleton of the host cell and interferes with microtubule dynamics, ultimately triggering apoptosis. This non-canonical function of Tat appears to be critical for the pathogenesis of lentiviral diseases, such as acquired immunodeficiency syndrome. Here, we compare the structure and activity of Tat proteins from three different types of lentiviruses, focusing on the roles of these proteins in the alteration of host microtubule dynamics and induction of apoptosis. We propose that further investigation of the Tat-microtubule interaction will provide important insight into the process of lentiviral pathogenesis and elucidate new avenues for the development of antiviral therapies.

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