Ba···ro···: ···cl···ca··· u···ul···om···er···ur···tl···re···t ···id···es···t ···po··· t···et···ne··· t···tm···-r···st··· m···r ···re···ve···so···r ···D)··· b···la···is···er···D)···hi···tu···in···ti···ed···et··· b···li···th···id···im···ti···ho···ne···SH···ev··· a···as···ia··· w··· k···mi···s ···id···es···t,···ti···he···ic···nd···ti···ic···l ···ec··· M···od···Th···wa··· s···nd··· e···or···ry···al···s ···da···dr··· f··· f··· N···sp···or··· r···om···d,···ac···-c···ro···d,···ub···bl··· c···so··· s···ie···f ···am··· i···np···en···wi···cu···nt···D ···= ··· o···ip···r ···re···on··· =···).···se···e ··· l···ls···re···as···d ···or···he···rs···nt···en··· s···ne··· k···mi···in···io···0.···g/···. ···wo···ek···sh··· p···ed···th···ec··· i···si··· D···es···n ··· a···do··· w··· m···ur···wi···th···on···me···& ···ng···er···ep···si···Ra···g ···le···AD··· a···th···na···-H···lt···Pl···ur···ca··· r···ec···el···Su···da···de···on···I)···s ···su··· a··· w···ht···av···ge··· t···Be···De···ss··· I···nt··· a···th···AD···su···de···em···Li···r ···ed···de···we···us···to···al···e ···el··· T···le···s ···a ···er···r ···re···ns···o ···am··· (···su···la···o)···on···ll··· f···th···id···se···, ···hi···us···an···ep···si···se···it···t ··· m···an···ay···, ···an··· p···-i···si··· R···lt···In···di···ua···wi···BD···ig··· b···li···TS···ev··· w··· a···ci···d ···h ···at···de···as···in···e ···er··· o···ep···si···(d···*T··· p···0.···7)···d ···ed···a ···ug···H,···< ···00···sy···om···os···et···ne···SH···ve···we···no···ss···at···wi···ch···es··· d···es···n,···he···ia···r ···se···it···n ··· p···-k···mi··· C···lu···n:···se···e ··· l···ls···re···so···te···it···et···ne···an···ep···sa···an···nt···nh···ni···ff···s ···BD···t ··· M··· T···e ···di··· s···es···ha···SH···y ···ve··· a···ed···iv···io···ke···f ···po··· a···hi···ig···a ···en···l ···ro···gl···ma···in···en···in···ta···e'···ec···is···f ···io··

Pr···ou···tu···s ···e ···ge···d ···t ···er···on···n ···te···tt···(W···mi···st···tu···ar···mp···at···in···ic···l ···ug··· a···be···io··· (···s)···ow···r,···nd···s ···di···si···te···r ···gi···(D··· s···ie···av···ee···nc···is···t.··· t··· l···e-···le···ga···al···s ···du···d ···th···NI··· S···id···Th···ht···nd···ha···ur···EN···A-···) ···so···um···e ···mi··· W···lt···ti··· a···ci···d ···h ···s.···ta···oc···in···as···an···di··· a···ss···te···an···es···in···M ···ro···uc···e ···su··· (···ct···al···is···op···ax··· d···us···ty···ea···if···iv··· a···ra···l ···fu···it···fo···5 ···tr···s ···e ···le···cr··· 4···oh···s.··· c···ar···th··· m···ur···am··· i···vi···ls···th···ps···ia···c ···gn···s ··· l···ti···hi···ry··· s···id···tt···t ···65···me···ag···5.···4.···fe···e=···8%···in···id···s ···h ···sy···at··· d···no··· b···no···B ···e.···li···al···nt···s;···18··· m··· a···34···.8···em···=5···%)···nd···di···ua···wi···no···nt···di···de···ia···si···nd··· S···(i···, ···lt···co···ol···n=···; ···n ···=2···±1···; ···al···2.···. ···al···co···re···he···me···re···mo···in···id···s ···h ···en···ui···al···ea···n ···71···me···ag···6.···5.···fe···e=···1%···cl···ca···on···ls···=1···; ···n ···=3···±1···; ···al···3.···, ··· h···th···on···ls···=1···; ···n ···= ···6±···5;···ma···61···).··· f···d ···tl···ut···at···ic···y ···ni···an···ff···s,···ch··· l···r ···ct···al···is···op···ss···at···wi···a ···to···of···ic··· a···mp···ov···an···bo···th···ff··· o···sy···at··· d···no···. ···se···fe··· w··· s···ng··· i···he···ro···ra···ta···ha···ic···di···on···or···/s···a ···mi···is···or··· c···os···an···up···or···ng···di··· f···ic···s.···fe···si··· w··· s···l ···he··· d···0.···. ···en···ui···al···ea···n ··· n···as···ia··· w··· a···ra···ns··· W···ic···tr···ur···Th···la···-s···e ···rd···te···eg···na···is···ve···d ···tl···eg···al···d ···ba···lt···ti··· i···M ···ro···uc···e ···in···id···s ···h ···is···y ···su···de···te···. ···gi···in···st···es···e ···de···o ···fi···wh···er···es···lt···ti··· a···a ···k ···to···or···ic···l ···av···r.

Th···sy···ma··· r···ew···d ···wo···me···an···si···NM···so···t ···co···re···ff···nt···ti···re···nt···ea···nt···or···ea···nt···si···nt···pr···io···TR···in···de···o ···il···te···id···e-···ed···oi···. ···it···tu···se···h ···Pu···d,···ch···e ···ra··· a···Em···e ···m ···ep···n ···il···ri···3t···20···id···if··· r···om···d,···nt···le···ri··· (···s)··· a···ts···th···pr···io···ho···d ··· r···on··· t···t ···st···o ···id···es···t ···al···al···CT···ad···0 ···ti···an···pe···tu···ar···an···ar···ip···s ···h ···ol···or···yc···ic···pr···io···er···xc···ed···he···ch···e ···k ···Bi···To···2 ··· u··· t···ss··· s···y ···li··· R···on···ra···wa···he···im··· o···om···ea···e.···ds···ti···(O··· u···g ···an··· e···ct···MA···e ···or···. ···m ···4 ···or··· 6···CT···er···nc···ed··· t··· a···ys··· e···mp···in···0,··· p···ic···nt···56···/4···M)···d ···se···at···re···en··· S···of···e ···tr···me··· d···ns···te··· h···er···sp···e ···e ···su···la···o ···sh···tr···me··· e···tr···nv···iv···he···y ···T)···in···cl···, ···ta···rs···ti···at··· (···),···pe···iv···ra···ra···l ···ne··· s···ul···on···TM··· k···mi··· a···ar···pr···le···Rs···ng···fr···1.···95···=[···5;···91···fo···ri···ra···e ···12··· (···CI···.0···40···])···r ···. ···er··· h···ro···ei···of···e ···el···s ···er··· (···47··· (···CI···6.···2%··· O···he···cl···d ···di··· 1···% ···e ···ed··· h···ng···gh···sk··· b···, ···13···s ···in···ow···sk···nd···.3···as···ow··· s··· c···er··· S···ra···ff···iv···re···en···fo···RD···ow···ro···t ···at···t ···ec···ac···s ···co··· (···, ···, ···S,···d ···am···),···d ···er···ho··· p···is··· r···lt···or···me···ut···t ···, ···co··· (···oc···in···ar···pr···le···Th··· f···in···ma···el···ui···ev···nc···as···tr···me···ch···es···r ···. ···dy···gi···at···: ···SP··· (···D4···34···84···© ···4.···e ···ho···).

Ma···ne···ar···g ···) ···hn···es···ve···in···po···ar··· i···he···ur···ag··· f···d ··· t···he···po···ti···fo···la···fy··· n···op···hi···ic···so···rs···ow···r,···e ···gn···ic···ed···iv···ow···of···e ···st··· a···ri···s ··· b··· l···te···y ···ll···mp···si···, ···k ···re···se···ti···es···da···le···ge···nd··· o···fi···ng···er···we···er···e ···se···mi···io···wi···th···ar···t ···ti···te···mp···si···to···te··· =···65···o ···vi···a ···er···za··· M···la···fi···io···en···ar···f ···or···pr···iv···is···er···DD···si···sh···ow···ne···an···on···ne···mo···s.···ve···in···ra···me···re···ro···ta···rd···d ···GM···na···is···pe···es··· F···Su···r,··· w··· a··· t···la···fy···D ···su···ea···y ···tr··· (··· w··· a···la···d ···ur··· o···ro··· 6··· B···af··· h···on···ng···e ···a,···g.···si···Co···t,···e ···an··· a···ra···dr···ed··· a···ox···te···52···Ac···ac···es···s ···se··· r···om···an···le···s ···e ···o ···er··· i···tr···fi···gr···s ···or···g ···ag···f ···et···nt···pr···an···se···um··· o···pi···es···d ···. ···ur···tu···s ···or···at··· h···er···me···on···br··· i···in···he···yp···ea···es···nd··· u···g ···e ···an··· m···in···nd···ep···ar···g ···ho···ma···ie···mo···en···ra···g ···sp···s.

Ba···ro···An···ge···ne···ex···s ···id···if···eu··· c···el···s ···oc···ed···th···ff···ng···ve···of···ic··· r··· a···de···op···ve···ra···-a···ng···er···ut··· t···od···te···ti···y ···hi···he···ne···l ···wo···.M···od···ec···ph···ol···ca···or···at···of···ic··· w··· e···ua··· u···g ···ne···nc···al···ap···(M··· i···5 ···lt···it···if···in···ev··· o···ui···e ···k.···ri···ME···ca···ng···ar···ip···s ···pl···d ···od···ed···fe···at···mp···it···so···ti···Ta··· M···da···we···so···e-···al···d ···th···am···(3···8 ··· f···ue···, ···ro···me···re··· e···ta···n-···ib···on···la···. ···am···ca···l ···el··· w···us···to···al···e ···fe···ce···n ···ne···vi···es···at···be···en···sk···ou··· A···oo···f-···ce··· o···-l···l,···lo···tu···of···ve···gh···sk···rt···pa··· e···in···ch···es··· g···a ···er···te···dm···st···io···f ···am··· (··· m···g)···n ···AR···ta···is···it···ap···an···su···de···ea···n ···ec···Re···ts···li··· s···-a···ci···on···it···ea···we···st···ge···n ··· h···es···ui···e ···k ···up···la···e ···al···th···gr···s,···ic···id···t ···fe···ro···ac···th··· H···er···mm···ow···fo···el···ea···co···re···o ···f-···e ···oc···io···wa···ou···in···e ···it···on··· c···ex···r ··· h···es···is···ro···an···he···su···an···os···io···in···at···or··· f···th···ow··· r··· g···p.···nn···iv··· e···ma··· b···ee···he···re···ns···ff···nt···ed···e ···he···ri···gr··· f··· t···fu···sa···e.···pl···t ···oc···io···wi···de··· w··· n···af···te···y ···am···, ··· e···nc···ga··· p···r ··· f···d ··· s···-d···h ···oc···io···in···e ···t ···ul···os···et···ne···mp···d ···ba···in···on···si···Di···re···al···pl···t ···ni···e ···ce···ng··· l··· a···de··· a···ar···o ···li···d ···su···de···sk···ig···gh···g ··· n··· f···ob···ti···me···re···f ···ci··· s···es···ha···co···ra···s ···t ···ul··· g···a ···iv···, ···ti···ar···in···e ···ul···ma···el···it···te···sk···in···lt···ls···v ···nt···er···CT···43···, ···00···11···on···si···Di···re···al···pl···t ···ni···e ···ce···ng··· l··· a···de··· a···ar···o ···li···d ···su···de···sk···ig···gh···g ··· n··· f···ob···ti···me···re···f ···ci··· s···es···ha···co···ra···s ···t ···ul··· g···a ···iv···, ···ti···ar···in···e ···ul···ma···el···it···te···sk···in···lt···ls···v ···nt···er···CT···43···, ···00···11··

Well-established animal models of depression have described a proximal relationship between stress and central nervous system (CNS) inflammation - a relationship mirrored in the peripheral inflammatory biomarkers of individuals with depression. Evidence also suggests that stress-induced proin-flammatory states can contribute to the neurobiology of treatment-resistant depression. Interestingly, ketamine, a rapid-acting antidepressant, can partially exert its therapeu-tic effects via anti-inflammatory actions on the hypothala-mic-pituitary adrenal (HPA) axis, the kynurenine pathway or by cytokine suppression. Further investigations into the relationship between ketamine, inflammation and stress could provide insight into ketamine's unique therapeutic mechanisms and stimulate efforts to develop rapid-acting, anti-inflammatory-based antidepressants.