项目来源

国家重点研发计划(NKRD)

项目主持人

高长有

项目受资助机构

苏州大学

立项年度

2016

立项时间

未公开

项目编号

2016YFC1100402

研究期限

未知 / 未知

项目级别

国家级

受资助金额

385.00万元

学科

生物医用材料研发与组织器官修复替代

学科代码

未公开

基金类别

未公开

关键词

血液微环境 ; 血液接触材料 ; 纤溶表面 ; 抗增生表面 ; 抗凝血表面 ; Blood microenvironment ; blood-contacting materials ; fibrinolytic surface ; anti-proliferative surface ; anticoagulant surface

参与者

陈红；于谦；郑青；石强；王进；闫顺杰

参与机构

中国科学院长春应用化学研究所；西南交通大学；威高集团

项目标书摘要：血管病变或血液接触性植介入器械会引起多种特征性血液微环境变化，如血管狭窄会引起血流剪切力的增大，血栓反应会产生活性凝血因子。针对这些微环境的变化，本课题拟通过利用表面微纳结构加工技术及化学/生物修饰技术，设计并制备基于新原理的自适应血液相容表面，使其对病变引起的血液微环境变化产生响应而激发抗凝血、溶栓及抗增生功能。通过系统研究表面与血浆蛋白质、血液细胞及血管壁细胞之间的相互作用，揭示自适应表界面生物功能的作用机制，获得具有生物微环境响应性血液接触材料表界面设计原理。示范研发1-2种新型血管植介入器械，完成体内外功能验证，申报临床实验许可，最终形成血管植介入器械表面改性的系列自有知识产权的关键技术。本课题具体开展的研究内容为：设计并开发了具有血栓应激性纤溶功能涂层并探索其产业化应用；构建了能随着体内微环境的变化而变化的抗炎抗血栓植介入材料；设计并构建了多种具有自适应性的抗凝/抗增生表界面；开展了高端留置与介入类医疗器械关键技术研发及产业化工作并开发了几种产品。课题研究成果将为血液接触性植介入医疗器械的研发提供理论指导和坚实有力的技术保障。

Application Abstract: Vascular lesions or blood-contacting implant devices cause a variety of characteristic changes in blood microenvironment.For example,vascular stenosis results in the increase in blood flow shear force,and thrombosis reactions produce active coagulation factors.This project intends to design and prepare adaptive blood compatible surfaces based on the new principle by using surface micro-nano structure processing technology and chemical/bio-modification technology;the resulted surfaces are designed to activate anticoagulation,thrombolysis and anti-proliferative function in response to the changes in the microenvironment resulted from vascular lesions.Through systematic investigation of the interaction between surface and plasma proteins,blood cells and vascular wall cells,the mechanism of interaction between biological functions of adaptive surfaces will be revealed,and the design principle of surfaces of blood-contacting materials with biological microenvironment-responsivity will be obtained.Finally,1-2 new types of vascular implant interventional devices will be developed,and their functions will be verified in vitro and in vivo.In this project,the specific tasks include design and development of a thrombus-responsive fibrinolytic functional coating and explore its industrial application;construction of an anti-inflammatory and anti-thrombotic implant intervention materials that can change the properties in response to the microenvironment in the body;design and development of a variety of adaptive anticoagulation/antiproliferation surfaces;construction of research and development and industrialization of key technologies for high-end indwelling and interventional medical devices and development of several products.The research results of the project will provide theoretical guidance and solid technical support for the development of blood-contacting implant medical devices.

项目受资助省

江苏省