Actin Filament 형성의 필수인자인 Profilin 단백질의 Post-Translational Modification(PTM)에 의한 새로운 조절기작 연구

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韩(略)科(略)

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유(略)

项目受资助机构

경(略)교(略)력(略)

项目编号

1(略)1(略)5(略)

财政年度

2(略),(略)0(略)0(略)

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未(略) (略)

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国(略)

受资助金额

1(略)3(略)0(略)韩(略)

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项目标书摘要:연구(略)rofilin i(略)ial effec(略)in filame(略)zation.Ou(略)s to prop(略) regulato(略)m of Prof(略)t-Transla(略)fication((略)mical fea(略)be analyz(略)us PTMs o(略)protein.W(略)nly used (略)ell line (略)ntiable n(略)ls and tr(略) out how (略)Ms are re(略)those cel(略) the effe(略)TMs-mutat(略)of Profil(略)we apply (略)to PolyQ (略)d suggest(略)ial thera(略)idates.  (略)t year of(略)iochemica(略)will be a(略)various P(略)ilin prot(略)o ubiquit(略)vitro sum(略)say will (略)d followi(略)spec anal(略)oteasome (略)ubiquitin(略)),proteas(略)radable u(略)on(Non-K4(略)oylation (略) in Profi(略) will be (略)and mutag(略)nd year o(略)we use co(略) mammalia(略)(NIH3T3)a(略)tiable ne(略)s(PC12)an(略)gure out (略)n PTMs ar(略) and what(略) of those(略)nerated i(略)Function (略) is exami(略)rving the(略) cell mor(略) neurite (略)n PC12.Ef(略) Profilin(略)teins wil(略)ed in mor(略) for bind(略) for acti(略)-Proline (略) 3rd year(略)h,inducib(略)model and(略)ellar ata(略)l model a(略)d and exa(略)ffect of (略)M mutants(略)hogenesis(略)isease mo(略)al activa(略)P2 relate(略)sed prote(略)dent degr(略)Profilin (略)ted and P(略)y related(略) Profilin(略)e cell wi(略)ned thoro(略)ll.      (略)y basical(略) the resu(略) function(略)eomics in(略) cell)as (略)tem and a(略) to mamma(略) based on(略) homology(略)e evoluti(略)approach (略)her resea(略)definitel(略)s,similar(略)ery easil(略)research.(略)ng the ba(略)ory mecha(略)filin-PTM(略)s it is b(略)e applied(略)isease,es(略)lyQ disea(略)potential(略)c candida(略)M-Profili(略)athway ar(略)

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