项目来源

芬兰研究理事会基金(AKA)

项目主持人

未公开

项目受资助机构

University of Helsinki

项目编号

33665

立项年度

2017

立项时间

未公开

项目级别

国家级

研究期限

未知 / 未知

受资助金额

434485.00欧元

学科

Plant Biology

学科代码

未公开

基金类别

Research Council of Finland-Academy research fellows

关键词

Mikrobiologia ; virukset ; tartuntataudit ; infektiot ; virustaudit ; epidemiat ; viruses ; communicable diseases ; infections ; virus diseases ; epidemics ; other

参与者

未公开

参与机构

未公开

项目标书摘要：Zoonotic viruses possess a global threat to the public health,by causing severe or even lethal disease.For decades arenaviruses were known as a odent-borne viruses that could cause viral hemorrhagic fever when transmitted to man.Few years ago we and others identified a novel group of arenaviruses in snakes with boid inclusion body disease(BIBD).The viruses formed a novel genus,reptarenavirus,in the family Arenaviridae.More recently we observed that snakes with BIBD are often co-infected with several reptarenaviruses.The aims of the proposed project are to study the immune evasion strategies reptarenaviruses in their reservoir host,and the mechanisms and factors(like co-infection)which contribute to development of BIBD.Additionally,we aim to study if the above mentioned would contribute to cross-species transmission,and if similar strategies are used by arenaviruses in general.The project utilizes cell cultures and molecular biology techniques for these studies.

Application Abstract: Zoonotic viruses possess a global threat to the public health,by causing severe or even lethal disease.For decades arenaviruses were known as a odent-borne viruses that could cause viral hemorrhagic fever when transmitted to man.Few years ago we and others identified a novel group of arenaviruses in snakes with boid inclusion body disease(BIBD).The viruses formed a novel genus,reptarenavirus,in the family Arenaviridae.More recently we observed that snakes with BIBD are often co-infected with several reptarenaviruses.The aims of the proposed project are to study the immune evasion strategies reptarenaviruses in their reservoir host,and the mechanisms and factors(like co-infection)which contribute to development of BIBD.Additionally,we aim to study if the above mentioned would contribute to cross-species transmission,and if similar strategies are used by arenaviruses in general.The project utilizes cell cultures and molecular biology techniques for these studies.