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Core A Administrative

项目来源

美国卫生和人类服务部基金(HHS)

项目主持人

未公开

项目受资助机构

Northeastern University

项目编号

5P01DA009158-19

立项年度

2018

立项时间

未公开

研究期限

未知 / 未知

项目级别

国家级

受资助金额

未知

学科

Cannabinoid Research; Drug Abuse (NIDA only); Endocannabinoid System Research; Substance Abuse;

学科代码

未公开

基金类别

Non-SBIR/STTR RPGs

关键词

未公开

参与者

MAKRIYANNIS, ALEXANDROS

参与机构

NATIONAL INSTITUTE ON DRUG ABUSE

项目标书摘要：RESEARCH & RELATED - OTHER PROJECT INFORMATION - PROJECT SUMMARY/ABSTRACT The Administrative Core (Core A) is a centralized facility designed to manage all operations related to this PPG. It facilitates the interactions between the collaborating laboratories and is located within the Center for Drug Discovery (Northeastern University). During this cycle, the Administrative Core has been functioning very effectively. Suitable modifications were made to accommodate new directions and personnel changes. The major tasks of this Core component will continue to be: a) communicate the central scientific theme to which all component projects will direct their research efforts and maintain a focused approach while fulfilling the PPG's overall specific aims; b) manage the fiscal aspects of the PPG, maintain financial records and other administrative functions; and c) promptly and properly distribute or coordinate the distribution of materials (novel ligands; other ligands developed in the PI's laboratory; receptor mutants) produced under the auspices of Core B and the other projects. The Administrative Core also takes responsibility for synchronizing the operations and communications between the individual laboratories involved in the PPG and other laboratories which interact collaboratively at no cost to the project. This effort includes recording and distributing materials produced to the participant laboratories and to the collaborating laboratories, together with maintaining and updating the data base related to this collaborative effort. Additional specific coordinating efforts include maintaining regular telephone conferences, the yearly group meeting of participants and collaborators, as well as other communications and the quarterly meetings with the Internal Advisory Committee, as well as the yearly formal meeting with the External Scientific Advisory Committee. The Administrative Core will manage the shared resources that are required for the performance of the interrelated tasks for the individual research projects. General administrative support related to this Program Project, including financial management, correspondence and preparation of reports and proposals, will also be provided by this Core Facility. The administrative portion of this grant seeks to keep all three projects and Core B focused on the overall research goals and to enhance communication between each branch of the grant. It will enhance the ability of collaborating laboratories to focus on the central PPG's overall goal which is the development of therapies for addiction and pain.

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  • 1.Approaches to Assess Biased Signaling at the CB1R Receptor

    • 关键词：
    • CANNABINOID 1 RECEPTOR; MU-OPIOID RECEPTOR; G-PROTEIN; FUNCTIONAL SELECTIVITY; CRYSTAL-STRUCTURE; CB2 RECEPTORS; LIGAND BIAS; AGONISM; MICE; TRANSDUCTION
    • Laprairie, Robert B.;Stahl, Edward L.;Bohn, Laura M.
    • 《CANNABINOIDS AND THEIR RECEPTORS》
    • 2017年
    • 会议

    G protein-coupled receptors, such as the cannabinoid type 1 receptor (CB1R), have been shown to interact with multiple binding partners to transmit signals. In both transfected cell systems and in endogenously expressing cell lines, CB1R signaling has been described as multifaceted. The question remains as to how this highly widely expressed receptor signals in a given cell at a given time in vivo. The concept of functional selectivity, or biased agonism, describes the ability of an agonist to engage the receptor in a manner that preferentially engages certain signaling interactions (e.g., G proteins) over others (e.g., beta-arrestins), presumably by stabilizing certain receptor conformations. There is growing interest in using such properties of ligands to direct signaling downstream of CB1R toward desirable therapeutic outcomes and to avoid adverse side effects. While it is not currently clear what pathways should be engaged and which should be avoided, the development of biased agonist tool compounds will aid in answering these questions. In this chapter, we discuss the approaches and caveats to assessing biased agonism at the CB1R.

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