目的···建立···材中···的气···检测···优化···代谢···N-···色谱···法和···代谢···CA···-M···S检···;2···同保···下的···液样···N-···N-···CA···测,···白血···随保···延长···败时···CN···CN···TC···;3···同保···下的···液样···N-···N-···CA···氰化···样品···-、···-和···A,···例血···中A···进行···探讨···化物···件检···优保···,并···化物···生物···。方···液样···经衍···气相···子捕···器检···物含···蛋白···离子···导检···测S···含量···液萃···C-···MS···TC···。在···、4···20···条件···测0···天血···N-···N-···CA···,确···-、···-和···A随···间的···律。···不同···保存···样品···存时···均可···CN···CN···TC···中-···条件···-产···,第···即可···最高···0.···μg···;4···下保···49···-出···,至···天C···度为···30···mL···℃条···第6···第7···测出···N-···样品···℃条···生的···-浓···,最···为1···.5···mL···的最···过健···烟人···学参···限;···件下···样品···N-···由4···g/···升至···ng···;-···的血···中S···的浓···与4···液样···接近···样品···℃条···生的···A浓···,第···即可···产生···浓度···7.···/m···℃与···℃条···存的···品中···A浓···相对···但非···中毒···AT···生的···大值···过健···烟人···学参···限,···件血···CA···浓度···康非···群的···考值···结论···推断···A可···氰化···的生···物,···于鉴···物生···和死···。疑···物中···检材···保存···将检···保存···封,···-2···下。

目的···医物···究中···生物···直是···难点···其组···和各···分比···确定···成混···解释···使得···能发···的效···前常···的生···是短···复序···ho···ta···m ···ea···TR···括常···ST···染色···R标···于混···TR···果的···也发···于峰···面积···比法···斯理···计学···,但···方法···准不···而且···遮盖···Ma···ng···fe···,传···R标···检测···比例···10···混合···次要···,如···比例···10···则无···次要···的分···年来···学者···更多···标记···单核···态性···Si···e ···le···de···ly···ph···,S···、插···位点···se···on···le···n ···ym···hi···IN···/D···、微···标记···cr···pl···pe···大的···定混···灵敏···由于···、D···微单···点由···态性···目前···为补···。2···年,···l ···者提···种联···DI···TR···IP···高灵···ST···座的···性结···于检···衡混···Zh··· L···提出···增阻···系统···pl···ca···n ···ra···ry···ta···n ···te···RM···理,···NP···R的···记检···将其···不平···斑。···上生···的优···们提···用D···SN···IP···cr···pl···pe···记检···衡混···降解···衡混···建立···位基···性引···扩增···SN···ho···序技···细管···Ca···la···el···ro···re···,C···术的···系,···了这···合遗···在不···合斑···不平···斑的···方法···建立···IP···P遗···对不···合斑···方法···）按···标准···据库···DI···NP···记:···IP···等位···度（···者缺···基）···bp···bp···2)···位点···于重···3)···和S···点的···≥0···4)···和S···点距···00···（2···等位···异性···术,···ri··· 3···计L···型上···和下···。（···建L···型复···体系···）设···基延···,构···aP···t微···系和···测方···5）···0例···族健···个体···人群···（6···复合···灵敏···属特···（7···单个···对二···不平···斑的···敏度···体系···与者···混合···测灵···2、···于D···SN···标记···衡混···降解···混合···析方···1）···下标···数据···选新···P-···遗传···1)···位点···IP···上下···0b···;2···HE···.2···DI···NP···记位···染色···2）···位基···性扩···,利···im···3软···L型···上游···下游···（3···L型···复合···系。···设计···延伸···构建···Ps···微测···和电···方法···）利···例山···健康···体,···群数···6）···合体···敏度···特异···7）···个基···二参···平衡···的检···度和···系对···者不···合斑···与者···平衡···的检···度。···立基···P-···ro···lo···e遗···对不···合斑···检材···方法···）按···标准···据库···DI···ic···ap···yp···标记···Mi···ha···ty···点位···P位···或者···50···内;···IP···Ps···HE···.2···DI···ic···ap···yp···标记···同染···（2···等位···异性···术,···ri··· 3···计L···型上···和下···。（···建L···型复···体系···）设···基延···,构···aP···t微···系和···测方···5）···0例···族健···个体···人群···（6···复合···灵敏···属特···（7···单个···对二···不平···斑的···敏度···体系···降解···二参···平衡···的检···度。···对1···0对···者模···斑进···个基···分析···:1···共建···个D···SN···,分···有1···20···P-···遗传···其中···基因···西人···多态···余基···态性···分布···ar···We···er···。两···的累···识别···别为···99···97···.9···63···。对···检测···有效···值为···01···29···个复···可以···1n···DN···。复···在检···与者···中的···与者···敏度···1:···1:···。单···座对···者混···的次···者进···时,···均为···00···、该···DI···ic···ap···yp···标记···汉族···多态···,分···Ha···-W···be···衡。···的累···识别···0.···80···9。···属特···DI···NP···记的···数从···个。···1个···的D···点无···,其···基因···合斑···平均···标记···nf···at··· m···er···lu··· v···e）···30···用0···gD···板即···目标···是为···更可···,我···使用···0n···A模···二参···合斑···参与···的单···检测···为1···0。···因座···与者···中次···者的···敏度···10···通过···00···拟混···44···座分···效性···个数···24···均为···5个···性标···,检···次要···的单···多,···参与···人识···高。···本实···构建···DI···NP···系和···IP···cr···pl···pe···系,···了其···降解···不平···斑、···不平···斑的···值。···-S···DI···ic···ap···yp···遗传···作为···NA···检测···种补···。未···筛选···样的···记。

体液···包含···摄入···相关···可用···体进···刻画···斑是···体液···的一···件现···见到···斑是···通过···中的···分进···,可···进行···如是···三高···包括···、高···高血···从而···提供···这种···无法···印进···识别···更加···意义···选取···种常···三高···研究···以指···为基···合超···相色···重四···合线···阱质···,建···印中···常见···药物···方法···的研···如下···建立···性客···纸）···透性···载玻···指印···种抗···物的···法,···CQ···Y ···C?··· C···3.···00··· C···mn···7μ···谱柱···.0···V/···酸-···醇作···相进···洗脱···分析···编程···监测···关联···增强···检测···在高···分析···,可···库检···增加···果的···。前···法选···蛋白···透性···接剪···0.···m ···作为···提取···透性···的指···50···50···/V···-水···湿的···取后···.5··· L···为沉···并加··· m···硫酸···吸水···。6···物的···为0···1～···50···/p···h,···为0···2～···00···pa···,基···在7···%～···%之···收率···.5···19···,日···精密···20···。2···了指···三高···验的···素。···留客···印中···检验···小,···不同···有适···指印···使药···面积···其中···显现···性粉···和“···”胶···影响···小。···药物···积会···时间···而降···分较···药物···留时···响。···集了···名服···高药···的指···用本···的方···分析···了方···效性···性。

目的···建立···5羟···-β···醇葡···酸（···yd···yt···to···l ···cu···id···TO···5羟···吲哚···乙酸···hy···xy···ol···-a···ic···d,···IA···高效···谱-···谱（···MS···）检···。2···5-···代谢···液中···动力···,为···酒案···法医···。方···.分···:乙···测:···0μ···尿液···瓶中···叔丁···mg···0m···50···,加···,混···样,···GC···标准···计算···量。···L和···IA···测:···10···于1··· L···中,···入1···内标···（D···TO···2-···AA···0n··· L···后加···0μ···（1···）,···分钟···合后···加至···柱,···正压···Ps···制流···-5···,干···钟。···下（···28···）进···,用···μL···复溶···,使···-M···S分···准曲···算G···和5···AA···2.···集饮···液中···L和···IA···动力···:1···0～···健康···试前···周内···史,···过敏···疾病···一夜···,在···点伴···（0···5m···Kg···后在···0.···1h···5h···、3···h、···7h···、1···15···4h···h、···收集···测定···集尿···容量···20···等量···存在···℃下···。饮···液中···L和···IA···研究···乙醇···尿液···,阴···液1···集后···-2···检。···1.···L和···IA···测方···TO···.0···g/···-2···m ···内呈···系,···大于···99···限和···限分···.0···/m···0.···g/···。5···AA···1μ··· L···μg···L范···线性···R~···0.···检测···量下···为0···μg···L和···5μ··· L···OL···HI···日内···精密···于1···准确···在9···2%···1.···和9···1%···2.···,稳···化率···1.···～3···%。···2名···未饮···液中···L和···IA···是0···±0···pm···nm···在饮···5小···大于···mo···mo···3～···降低···pm···nm···下。···5例···性尿···GT···5-···A比···于1···ol···ol···乙醇···样本···乙醇···液样···OL···HI···值小···pm···nm···乙醇···GT···5-···A之···著正···r=···63···论:···建立···中G···和5···AA···量分···准确···,可···于饮···TO···-H···定量···通过···名受···次饮···液中···L和···IA···动力···,G···和5···AA···测时···酒后···～9···乙醇···时限···推断···间方···醇更···;通···8例···性样···GT···5-···A比···,证···二者···于1···ol···ol···近期···用于···群;···ea···n相···析研···液中···含量···OL···HI···显著···。以···证明···L和···IA···作为···力的···段,···鉴定···中饮···提供···据。

目的···建立···件位···（c···it···ed···ac···re···en···CP···物模···.研···西酮···谢物···小鼠···小鼠···代谢···规律···血液···西酮···时限···比较···鼠和···鼠给···谢动···律的···方法···小鼠···模型···小鼠···组:···,C···对照···中A···C组···照6···mg···,1···5m···g,···g/···腔注···验过···期:···（第···,条···期（···9天···试期···0天···试结···统计···鼠在···停留···计算···值（···与前···间差···实验···均值···误（···n±···）来···采用···S2···统计···行数···,以···.0···著性···准。···常小···后体···谢动···小鼠···禁水···时后···分成···,C···对照···中A···C组···照6···mg···,1···5m···g,···g/···腔注···为9···甲卡···溶液···药后···in···mi···0m···1h···,3···h,···8h···h,···,2···30···眦静···血2···L,···℃冰···待检···数据···AS···.8···力学···行代···学分···PS···.0···件,···检验···分析···成瘾···药后···代谢···:按···P实···定的···分为···A,···和盐···组。···P测···束后···统计···出A···C三···导出···CP···。再···前确···体内···卡西···代谢···在服···3m···15···,3···n,···2h···,4···h,···10···2h···h,···,内···丛采···0μ···20···保存···所得···用D···.2···代动···件进···动力···;S···23···计软···用t···方差···结果···成瘾···确定···学实···以C···（C···sc···）来···通过···析得···B,···实验···照组···比较···表现···差异···0.···。表···B,···均表···显的···效应···P效···在C···验中···动物···物相···中停···的增···少）···爱（···该环···明药···爱（···效应···实验···鼠表···显的···爱效···.正···给药···的代···学过···常小···后3···在血···可检···西酮···酮、···及伪···。甲···在血···代谢···符合···收一···模型···动力···受给···的影···除半···给药···正相···,B···消除···分别···48···.5···0.···给药···h虽···出甲···,,···定量···;代···西酮···碱和···碱的···限与···量呈···,A···C组···限分···h,···10···黄碱···黄碱···浓度···卡西···浓度···5%···卡西···%以···.成···给药···谢动···程:···鼠给···mi···液中···出甲···、卡···麻黄···麻黄···卡西···液中···动力···一级···室开···,A···C组···衰期···0.···h,···88···.5···。给···0h···检出···酮和···,但···量限···代谢···碱和···碱的···限与···量呈···,麻···A,···组的···限分···h,···8h···黄碱···B,···检出···别为···8h···h。···和伪···的峰···均在···酮峰···的1···或卡···6%···结论···建立···西酮···小鼠···置偏···模型···用C···型对···药物···应进···。2···了正···给药···甲卡···其代···代谢···研究···药物···正常···内的···力学···用一···一室···述。···立了···鼠给···内甲···及其···的代···学研···,药···在成···体内···动力···可用···收二···描述···正常···成瘾···药后···酮及···物在···浓度···势基···,与···关。···鼠和···鼠给···比,···酮代···达峰···本相···且代···黄碱···黄碱···时限···近。···小鼠···会使···酮及···物的···度增···时使···卡西···出时···明显···通过···卡西···出时···与甲···相近···甲卡···其代···西酮···碱、···碱峰···的高···以判···是甲···成瘾···需要···的实···进行···