Derivation and · · · human stem · · · cells

项目来源

美国卫生和人类服务部基金(HHS)

项目主持人

LIBERMAN, ELLEN ·

项目受资助机构

INDIANA UNIV-PURDUE · · ·

立项年度

2019

立项时间

未公开

项目编号

5R01EY024984-05

项目级别

国家级

研究期限

未知 / 未知

受资助金额

354008.00美元

学科

Aging; Clinical · · · and Disorders · · · Neurosciences; Regenerative · · · Research; Stem · · · Induced Pluripotent · · · Cell Research · · · Stem Cell · ·

学科代码

未公开

基金类别

Non-SBIR/STTR RPGs

关键词

未公开

参与者

MEYER, JASON ·

参与机构

NATIONAL EYE ·

项目标书摘要:DESCRIPTION (provided · · · induced pluripotent · · · provide a · · · stem cells · · · potential to · · · cell type · · · including retinal · · · when derived · · · own somatic · · · the potential · · · as a · · · glaucoma. Previously, · · · the ability · · · retinal cell · · · ganglion cells · · · the current · · · be derived · · · normal-tension primary · · · which would · · · of cells · · · predisposition to · · · damage. Conversely, · · · will be · · · point of · · · have a · · · glaucomatous injury. · · · retinal ganglion · · · these two · · · for the · · · contributing to · · · test this · · · cells derived · · · will be · · · accumulation of · · · characteristic of · · · both under · · · well as · · · environmental stressors · · · peroxide. Viability · · · will also · · · the use · · · to identify · · · two populations. · · · that such · · · in increased · · · those cells · · · patients compared · · · from ocular · · · the role · · · the progression · · · phenotype will · · · will be · · · hiPSCs and · · · ganglion cells. · · · performed to · · · of astrocyte · · · glaucoma disease · · · completion of · · · this proposal · · · hiPSC- derived · · · s a · · · for studies · · · will also · · · significant basis · · · design new · · · treatment of · ·

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  • 2.Ex···si···of···ti···ug···pr···ct···s ···an···se···ed···de···f ···an···ur···te···st···ce···de···ed···ga···ds

    • 关键词:
    • RETINAL GANGLION-CELLS; HUMAN BRAIN-DEVELOPMENT; HUMAN FETAL RETINA; AXONAL-TRANSPORT; DIFFERENTIATION; GROWTH; ASTROCYTES; RELEVANCE; GLAUCOMA; BDNF
    • Fl···r,···ar···e ···La···ar···ai··· S···ar···, ···e;···el··· P···a ···Va···rW···, ···st···B.···an···Ka···Ch···;G···s,···ti···ey··· J···n ··
    • 《ST···CE···RE···TS》
    • 2021年
    • 16卷
    • 9期
    • 期刊

    Th···ev···pm··· o···he···su···sy···m ···ol··· t···co···in···on··· s···ia···nd···mp···l ···nt···o ···ci···th···rg···za···n ···va···d ···l ···es···nc···in···he···on···io···f ···ns···om···ti··· g···li···ce··· (···s)··· p···-s···pt···ta···ts··· t···br···. ···in···or···oi···re···it···te···ny···at···s ···re···al···ve···me··· y···ha···la···d ···ns···am···rg··· i··· w···h ··· a···s ···en···li···in···he···il··· t···od···pr···ct···s ···th···um···vi···l ···te···To···dr··· t···e ···ue···re···al···ga···ds···re···ne···ed···d ···an···d ···o ···in···tr···ss···lo···mo··· o···he···su···sy···m ···h ···ti··· a···th···mi···rg···id···RG···re···nd···to···vi···me···l ···s ··· e···nd···ax··· d··· i··· a···mb···ds···od···ng···e ···je···on···f ··· v···al···st··· I···dd···on···GC···rv···l ··· e···nc···in···ng···rm···se···oi··· o···co···g ···or···mi···io···of···ti··· o···no··· i···hi···RG···ar···os···Ov···ll···he···ap···ac··· w··· f···li···e ···di···of···ma···is··· s···em···ve···me··· a···el···s ···ea··· o···nj···es··· t··· c···ic···pa···ay·

    ...
  • 4.Re···al···ng···n ···ls···th···Gl···om···PT···50···ut···on···hi··· N···od···ne···iv···he···yp···wh···De···ed···om···re···im···io··· R···na···rg···id·

    • Va···rW···,K···ti···;H···g,···g-···eh···n,···li···La···ar···il···S;···go···la···se···Al···p,···a ···en···h,···ly···Da···Pe···ao···an···hi···en···en···C;···mi···Th···or···;M···r,···on···
    • 《St···Ce···Re···ts》
    • 2020年
    • 15卷
    • 1期
    • 期刊
  • 5.En···y ···ab···sm···d ···oc···dr··· S···ro···e ···on···od···io···n ···-s···to···ic···ri···l ···ro···De···ed···om···ma···nd···d ···ri···en···te···el···Ex···ss··· M···nt···nt···ti·

    • 关键词:
    • Huntington's disease; Mitochondria; Neurons; Respiration; Glycolysis;Reactive oxygen species;YAC128 MOUSE MODEL; ISOLATED BRAIN MITOCHONDRIA; OXIDATIVE-METABOLISM;DISEASE; DYSFUNCTION; DAMAGE; GENE; TRAFFICKING; XJB-5-131; DYNAMICS
    • Ha···to···Ja···;B···to···sk···Ta···na···id···, ···ha···ak···i;···, ···li···Cu···ns···he···re···;M···r,···so···.;···st···ts··· N···ol··
    • 《MO···UL···NE···BI···GY》
    • 2020年
    • 57卷
    • 2期
    • 期刊

    In···e ···se···st···, ···in···ti···ed···et··· m···nt···nt···ti···mH··· i···ir···it···on···al···nc···ns··· h···n ···ia··· n···on···er···d ···m ···uc···pl···po···t ···m ···ls···PS···. ···ia··· n···on···nd···tr···te···er···d ···m ···Cs···om···af···te···nd···du··· (···l)···d ···ti···on···di···se···D)···ti···s ···h ··· g··· c···ai···g ···re···d ···be···f ··· r···at···er···se···o ···es···he···fe···of···TT··· b···ne···ti···an···it···on···al···pe···id···ni···pr···ct···. ··· h···n ···ro···we···th···ug··· c···ac···iz···an···ho···to···pr··· M···, ···PP··· G···, ···ap···, ··· P···5.··· h···n ···ro···an···st···yt···ex···ss··· m···, ··· r···o ···mH···to···ld···pe···nt···ti···HT···wa···:1···he···ma···eu···s ···e ···it···e ··· c···d ···er··· a···on···te···al···co···rm··· s···es···l ···ve···on··· i···s ···o ···ct···al···ur···. ··· n···on···nd···tr···te···ro···tr···nd···du··· a···HD···ti···s ··· s···la···ev··· o···DP···d ··· a···co···ra··· r···ir···ry···d ···co···ic···ti···ie···Th···it···on···al···ss···it···on···al···mb···e ···en···l,···d ···er···de···io···ro···ti···in···ma···eu···s ···ea··· t···e ···il···re···dl··· o···HT···re···ce···he···es··· r···lt···re··· l··· w··· t···re···ts···ta···d ···ou···re···us···ud··· w··· i···at···br··· m···ch···ri···nd···lt···d ···ia··· n···on···ro···AC··· a···R6···mi··· i···hi···we···mo···ra··· t··· m···nt···nt···ti···t ···ly···ag···of··· p···ol··· d··· n···de···io···e ···oc···dr··· f···ti···. ···ra··· o···re···ts···gu···ga···t ···en···et···de···it···s ···ac··· i···D ···ho···es···an···ug···t ···t ···er···tr···nt···pr···ss···mi··· b···or···el···nt··· t···de···op···t ···HD···th···gy·

    ...
  • 7.Di···re···al···sc···ib···ty··· r···na···an···on···ll···bt···s ···ac··· a···ch···ic···de···of···ju···an···is···e.

    • 关键词:
    • 0 / Neuroprotective Agents
    • Va···rW···, ···st···B;··· B···Al···o,···rg···;A···op···nn···;C···, ···xa···Wa··· S···me···ey··· J···n ·
    • 《Sc···ti··· r···rt·》
    • 2020年
    • 10卷
    • 1期
    • 期刊

    Re···al···ng···n ···ls···GC···ar··· h···ro···eo···po···at··· o···eu···s,···mp···ed··· n···ro···su···pe···ha···or···yn···on···ly··· t···sm···vi···l ···or···io···o ··· b···n.··· b···di···di···de···su···as···au···a,···Cs···e ··· m··· c··· t··· t···eg···ra···an···ea···o ···s ···vi···n.···ev···s ···di···ha···id···if··· a···ch···ct···ze··· v···et···f ··· s···yp···in···im···mo···s,···th···h ···y ···an···l ···st···es···mo···ra···th···if···en···l ···s ···th··· R···su···pe···n ···po··· t···is···e ···in···y.···us···ff···s ···th···ur···t ···dy···il···d ···h ···on···(b··· o···us···) ··· a···e ···ti···er···cr···, ···) ··· m···ls··· c···ac···iz···is···e ···po··· a···di···re···al···ss··· R···su···pe···Be···oc···si···an···NC···ti··· d···ns···te···ig···ic··· R···lo··· g···l ···ct···ty···d ···pt···s ···pa··· t···on···l ···in··· I···rt···ly···ea···cc···io···nd···C ···in···re···te···n ···fe···ti···su···pe···ec···c ···s ···RG··· w··· a···gh···sc···ib···ty···r ···ha···nd···re···on···le···ve···Cs···d ···fe···ti···su···va···f ···GC···Re···ts··· t··· s···y ···ve··· a···mp···an···ou···ti···fo···ut··· e···ri···ts···cu··· o···he···ch···sm···es···in···n ··· l··· o···GC···n ···ic···ur···th···, ···we···as···e ···el···en···f ···ge··· t···ap···ic···or···C ···ty···sp···fi···eu···ro···ti···

    ...
  • 8.As···cy··· R···la···th···ev···pm··· a···Ma···at··· o···et···l ···gl··· C···s ···iv···fr···Hu··· P···ip···nt···em···ll·

    • Va···rW···,K···ti···;V···Ri···ma···le···he···ar···K;···dh···Ak···ya···sh···Fl···r,···ri··· M···de···ly···M;···er···ch··· C···uc···2n···nt···y ···um···s,···od··· R···ye···as···S;
    • 《St···ce···re···ts》
    • 2019年
    • 12卷
    • 2期
    • 期刊
  • 10.Ad···ce···n ··· D···er···ia···n ···Re···al···ng···n ···ls···om···ma···lu···ot··· S··· C···s

    • 关键词:
    • VESICLE-LIKE STRUCTURES; HUMAN IPS CELLS; PIGMENT EPITHELIUM; FUNCTIONAL AXONS; GENERATION; OPTINEURIN; GLAUCOMA; STAGE; MOUSE; MUTATIONS
    • Oh···ac···, ···ah···;L···er···ir···n ···Fl···r,···ar···e ···Fe···, ···se···;E···r,···ch··· C···ey··· J···n ··
    • 《PL···PO···T ···M ···LS··· E···DI···SE···ER···》
    • 2019年
    • 会议

    Hu··· p···ip···nt···em···ll···PS···te···ol··· h···re···ut···iz···th···ie···of···ol··· t···ug···he···pr···de···d ···li···to···ud···he···ff···nt···io···f ···an···ll···n ···ro···n ··· p··· d···de···PS···ha···be···ap···ed··· s···y ···el···en···mo··· d···as···de···op···ug···an···ev··· c··· r···ac···nt···er···es···r ···er··· b···og···l ···te··· O···ar···ul···in···es···s ··· a···ic···on··· t··· t···no···y ···st··· a···tr··· o···c ···ro···hi···su···as···au···a.···ti··· g···li···ce··· (···s)···e ··· p···ar···el···yp···ff···ed··· t···e ···ea···, ··· o··· l···, ···y ··· u···le··· r···ne···e ···ad···ho··· T··· n···ss···te···he···ve···me···of···ra···ie···o ···dy···e ···ha···ms··· d···ne···io···s ···l ···de···op···an···ti···l ···ra···ti···pp···ch···to···ea···ar··· a···la···st··· d···as···ro···ss···. ···er··· p···oc··· h··· b··· e···bl···ed··· d···ve···Cs···om···SC···wi···th···bi···y ···ge···at···ar···po···at···s ···hu··· R··· f···tr···la···na···pp···at···s.··· t··· r···ew···he···y ···li···io···of···SC···it··· t···re···al···el···re···sc···ed···nc···in···he···e ···th··· c···s ···de···op···ta···od···, ···ea···mo···s,···ug···ve···me··· a···fi···ly···el···ep···em··· t···ap···. ···gr···er···ta··· t···cu···nt···po···fo···es··· t···di···re···at··· o···PS···er···d ···s ··· t···ma···un···e ···ra···ri···cs···so···te···it···he···ce··· i···it···in···di···th··· g···ti···de···fi···, ···ir···ec···ph···ol···ca···ct···ty···nd···ei···or···lo···al···tu···io···Al···de···ib···is···e ···re···pr···es···n ··· u···of···ti···-s···if···hP··· t···tu···op··· n···op···ie···ff···in···GC···wi···em···si···n ··· u···of···es···GC···or···ud···g ···ea···me···ni··· a···pa···ge···is···ru···cr···in···an···el···ep···em··· t···ap··· i···ut··· s···ie··

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