Derivation and · · · human stem · · · cells

项目来源

美国卫生和人类服务部基金(HHS)

项目主持人

LIBERMAN, ELLEN ·

项目受资助机构

INDIANA UNIV-PURDUE · · ·

立项年度

2019

立项时间

未公开

项目编号

5R01EY024984-05

项目级别

国家级

研究期限

未知 / 未知

受资助金额

354008.00美元

学科

Aging; Clinical · · · and Disorders · · · Neurosciences; Regenerative · · · Research; Stem · · · Induced Pluripotent · · · Cell Research · · · Stem Cell · ·

学科代码

未公开

基金类别

Non-SBIR/STTR RPGs

关键词

未公开

参与者

MEYER, JASON ·

参与机构

NATIONAL EYE ·

项目标书摘要:DESCRIPTION (provided · · · induced pluripotent · · · provide a · · · stem cells · · · potential to · · · cell type · · · including retinal · · · when derived · · · own somatic · · · the potential · · · as a · · · glaucoma. Previously, · · · the ability · · · retinal cell · · · ganglion cells · · · the current · · · be derived · · · normal-tension primary · · · which would · · · of cells · · · predisposition to · · · damage. Conversely, · · · will be · · · point of · · · have a · · · glaucomatous injury. · · · retinal ganglion · · · these two · · · for the · · · contributing to · · · test this · · · cells derived · · · will be · · · accumulation of · · · characteristic of · · · both under · · · well as · · · environmental stressors · · · peroxide. Viability · · · will also · · · the use · · · to identify · · · two populations. · · · that such · · · in increased · · · those cells · · · patients compared · · · from ocular · · · the role · · · the progression · · · phenotype will · · · will be · · · hiPSCs and · · · ganglion cells. · · · performed to · · · of astrocyte · · · glaucoma disease · · · completion of · · · this proposal · · · hiPSC- derived · · · s a · · · for studies · · · will also · · · significant basis · · · design new · · · treatment of · ·

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  • 1.Ad···ce···n ··· D···er···ia···n ···Re···al···ng···n ···ls···om···ma···lu···ot··· S··· C···s

    • 关键词:
    • VESICLE-LIKE STRUCTURES; HUMAN IPS CELLS; PIGMENT EPITHELIUM; FUNCTIONAL AXONS; GENERATION; OPTINEURIN; GLAUCOMA; STAGE; MOUSE; MUTATIONS
    • Oh···ac···, ···ah···;L···er···ir···n ···Fl···r,···ar···e ···Fe···, ···se···;E···r,···ch··· C···ey··· J···n ··
    • 《PL···PO···T ···M ···LS··· E···DI···SE···ER···》
    • 2019年
    • 会议

    Hu··· p···ip···nt···em···ll···PS···te···ol··· h···re···ut···iz···th···ie···of···ol··· t···ug···he···pr···de···d ···li···to···ud···he···ff···nt···io···f ···an···ll···n ···ro···n ··· p··· d···de···PS···ha···be···ap···ed··· s···y ···el···en···mo··· d···as···de···op···ug···an···ev··· c··· r···ac···nt···er···es···r ···er··· b···og···l ···te··· O···ar···ul···in···es···s ··· a···ic···on··· t··· t···no···y ···st··· a···tr··· o···c ···ro···hi···su···as···au···a.···ti··· g···li···ce··· (···s)···e ··· p···ar···el···yp···ff···ed··· t···e ···ea···, ··· o··· l···, ···y ··· u···le··· r···ne···e ···ad···ho··· T··· n···ss···te···he···ve···me···of···ra···ie···o ···dy···e ···ha···ms··· d···ne···io···s ···l ···de···op···an···ti···l ···ra···ti···pp···ch···to···ea···ar··· a···la···st··· d···as···ro···ss···. ···er··· p···oc··· h··· b··· e···bl···ed··· d···ve···Cs···om···SC···wi···th···bi···y ···ge···at···ar···po···at···s ···hu··· R··· f···tr···la···na···pp···at···s.··· t··· r···ew···he···y ···li···io···of···SC···it··· t···re···al···el···re···sc···ed···nc···in···he···e ···th··· c···s ···de···op···ta···od···, ···ea···mo···s,···ug···ve···me··· a···fi···ly···el···ep···em··· t···ap···. ···gr···er···ta··· t···cu···nt···po···fo···es··· t···di···re···at··· o···PS···er···d ···s ··· t···ma···un···e ···ra···ri···cs···so···te···it···he···ce··· i···it···in···di···th··· g···ti···de···fi···, ···ir···ec···ph···ol···ca···ct···ty···nd···ei···or···lo···al···tu···io···Al···de···ib···is···e ···re···pr···es···n ··· u···of···ti···-s···if···hP··· t···tu···op··· n···op···ie···ff···in···GC···wi···em···si···n ··· u···of···es···GC···or···ud···g ···ea···me···ni··· a···pa···ge···is···ru···cr···in···an···el···ep···em··· t···ap··· i···ut··· s···ie··

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